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Conventional nuelear medieine proeedures study the dis- tribution
of radiolabelled eompounds (radiopharmaeeutieals) in the body under
physiologieal as well as under pathologieal eonditions. Beeause of
their ability to visua- lise and to quantify the distribution of
radiopharmaeeuti- eals within the body by means of external
deteetors, nuelear medieine teehniques are basieally non invasive
and funetion oriented. The spatial variation of the traeer
distribution in the field of view, or the ehange in distribution
during a time interval are interpreted as representing speeifie
phy- siologie or pathophysiologie processes. As eompared to other
diagnostie imaging teehniques, the spatial resolution of
seintigraphie images is rather poor, their temporal resolu- tion is
good. Faetors that will therefore determine the ultimate diag-
nostie value of a seintigraphie study inelude 1. The speeifieity of
the labelled eompounds for the process under study, 2. The
resolution in time and space of the instrumentation, and its
ability of measuring quantitatively tissue aetivity eoneentrations,
3. The formulation of physiologieal or pathophysiologieal models
from whieh the distribution of the traeer ean be predieted. 2 While
interpreting nuclear medicine data, the interrelations between
these factors should permanently remain under consi- deration. The
generalised use of minicomputers has resulted in major advances in
information processing in nuclear medicine imaging procedures.
Central to this is image digitisation.
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