Nitric oxide (NO) has been discovered to play a fundamental role in a number of biological phenomena. This book describes various aspects of nitric oxide biology, physiology and pharmacology. It is divided into three sections. The first part deals with the basic chemistry and enzymology of NO, thus laying a molecular basis for what follows. The middle part surveys the physiological roles of NO under normal conditions. The concluding part explores the relevance of NO to disease, both as a pathogenic factor and a therapeutic target. The book thus provides detailed information on NO biology to the reader unfamiliar with the field and represents a reference work for scientists working in an NO-related field of biomedical research. Each chapter, written by experts in their fields, gives a broad introduction followed by a comprehensive review of the current knowledge and a detailed reference list.

B. Brune et al.: Protein Thiol Modification and Apoptotic Cell Death as cGMP-Independent Nitric Oxide. H. Esterbauer and P. Ramos: Chemistry and Pathophysiology of Oxidation of LDL. C. Gotz and M. Montenarh: DNA Damage, DNA Repair, and Apoptosis. E.R. Werner et al.: Biosynthesis of Nitric Oxide: Dependence on Pteridine Metabolism. R. Bernhardt: Cytochrome P450: Structure, Function, and Generation of Reactive Oxygen Species. B. Epe. DNA Damage Profiles Induced by Oxidizing Agents