Arch-criminal Gru (voice of Steve Carell) and his minions return in this Academy Award-nominated, computer-animated comedy sequel. Now living a life of domestic bliss in suburbia with adopted daughters Margo (Miranda Cosgrove), Agnes (Elsie Fisher) and Edith (Dana Gaier), Gru's world is turned upside down when he finds himself abducted by agent Lucy Wilde (Kristen Wiig) of the Anti-Villain League on the orders of boss Silas Ramsbottom (Steve Coogan). All is not what it seems, however, for with the world threatened by the new and dastardly super-villain known as Eduardo (Benjamin Bratt), it falls to the unique talents of Gru and his minions to step up to the plate and finally save the day. The film received Oscar nominations for Best Animated Feature and Best Original Song.

Arch-criminal Gru (voice of Steve Carell) and his minions return in this Academy Award-nominated, computer-animated comedy sequel. Now living a life of domestic bliss in suburbia with adopted daughters Margo (Miranda Cosgrove), Agnes (Elsie Fisher) and Edith (Dana Gaier), Gru's world is turned upside down when he finds himself abducted by agent Lucy Wilde (Kristen Wiig) of the Anti-Villain League on the orders of boss Silas Ramsbottom (Steve Coogan). All is not what it seems, however, for with the world threatened by the new and dastardly super-villain known as Eduardo (Benjamin Bratt), it falls to the unique talents of Gru and his minions to step up to the plate and finally save the day. The film received Oscar nominations for Best Animated Feature and Best Original Song.

While Gru, the ex-supervillain is adjusting to family life and an attempted honest living in the jam business, a secret Arctic laboratory is stolen. The Anti-Villain League decides it needs an insider's help and recruits Gru in the investigation.

Together with the eccentric AVL agent, Lucy Wilde, Gru concludes that his prime suspect is the presumed dead supervillain, El Macho, whose teenage son is also making the moves on his eldest daughter, Margo.

Seemingly blinded by his overprotectiveness of his children and his growing mutual attraction to Lucy, Gru seems on the wrong track even as his minions are being quietly kidnapped en masse for some malevolent purpose.