Progress in Medicinal Chemistry, Volume 57, provides a review of eclectic developments in medicinal chemistry, with this volume including chapters on the CaSR field, CFTR modulators in cystic fibrosis, macrocycles, VMAT2 inhibitors, and Big Data in Drug Discovery.

Progress in Medicinal Chemistry, Volume 61 provides a review of eclectic developments in medicinal chemistry, with each chapter written by an international board of authors.

Progress in Medicinal Chemistry, Volume 60 provides a review of eclectic developments in medicinal chemistry. Each chapter is written by an international board of authors who cover topics including Venoms in Drug Discovery, Designing Protacs as a Drugs, Automated synthesis and enabling tools for Medicinal Chemistry, Use of Molecular Docking Computational Tools in Drug Discovery, and An industrial perspective on co-crystals: screening, identification and development of the less utilized solid form in drug discovery and development.

Progress in Medicinal Chemistry, Volume 56 provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a potential new era for Chagas Disease drug discovery, and imaging in drug development. Specific chapters cover timely topics, such as the development of LRRK2 inhibitors for the treatment of Parkinson's, and recent discoveries and developments in TRPA1 modulators. Users will find a comprehensive resource on the topic of medicinal chemistry that also discusses avenues for the acceleration of drug discovery programs.

A Brief History of Time for the 21st Century At the heart of our galaxy lies a monster so deadly, not even light can escape its grasp. Its secrets lie waiting to be discovered. It’s time to explore our universe’s most mysterious inhabitants Black Holes At the heart of the Milky Way lies a supermassive black hole 4 million times more massive than our Sun. A place where space and time are so warped that light is trapped if it ventures within 12 million km. According to Einstein, inside lies the end of time. According to 21st-century physics, the reality may be far more bizarre. Black holes lie where the most massive stars used to shine and at the edge of our current understanding. They are naturally occurring objects, the inevitable creations of gravity when too much matter collapses into not enough space. And yet, although the laws of nature predict them, they fail fully to describe them. Black holes are places in space and time where the laws of gravity, quantum physics and thermodynamics collide. Originally thought to be so intellectually troubling that they simply could not exist, it is only in the past few years that we have begun to glimpse a new synthesis; a deep connection between gravity and quantum information theory that describes a holographic universe in which space and time emerge from a network of quantum bits, and wormholes span the void. In this groundbreaking book, Professor Brian Cox and Professor Jeff Forshaw take you to the edge of our understanding of black holes; a scientific journey to the research frontier spanning a century of physics, from Einstein to Hawking and beyond, that ends with the startling conclusion that our world may operate like a giant quantum computer.

In "The Quantum Universe," Brian Cox and Jeff Forshaw approach the world of quantum mechanics in the same way they did in "Why Does E=mc2?" and make fundamental scientific principles accessible--and fascinating--to everyone.

The subatomic realm has a reputation for weirdness, spawning any number of profound misunderstandings, journeys into Eastern mysticism, and woolly pronouncements on the interconnectedness of all things. Cox and Forshaw's contention? There is no need for quantum mechanics to be viewed this way. There is a lot of mileage in the "weirdness" of the quantum world, and it often leads to confusion and, frankly, bad science. "The Quantum Universe" cuts through the Wu Li and asks what observations of the natural world made it necessary, how it was constructed, and why we are confident that, for all its apparent strangeness, it is a good theory.

The quantum mechanics of "The Quantum Universe" provide a concrete model of nature that is comparable in its essence to Newton's laws of motion, Maxwell's theory of electricity and magnetism, and Einstein's theory of relativity.

The international bestseller: an introduction to the theory of relativity by the eminent physicists Brian Cox and Jeff Forshaw What does E=mc2 actually mean? Dr. Brian Cox and Professor Jeff Forshaw go on a journey to the frontier of twenty-first century science to unpack Einstein's famous equation. Explaining and simplifying notions of energy, mass, and light-while exploding commonly held misconceptions-they demonstrate how the structure of nature itself is contained within this equation. Along the way, we visit the site of one of the largest scientific experiments ever conducted: the now-famous Large Hadron Collider, a gigantic particle accelerator capable of re-creating conditions that existed fractions of a second after the Big Bang. A collaboration between one of the youngest professors in the United Kingdom and a distinguished popular physicist, Why Does E=mc2? is one of the most exciting and accessible explanations of the theory of relativity.

Progress in Medicinal Chemistry, Volume 58, provides a review of eclectic developments in medicinal chemistry, with each chapter written by an international board of authors. Topics covered in this new release include Amyotrophic lateral sclerosis (ALS), Covalent-binding Drugs, Natural Product Drug Delivery - A Special Challenge?, and SMN2 gene splicing modifier, and more.

Have you ever looked at your Library's key performance indicators and said to yourself "so what!"? Have you found yourself making decisions in a void due to the lack of useful and easily accessible operational data? Have you ever worried that you are being left behind with the emergence of data analytics? Do you feel there are important stories in your operational data that need to be told, but you have no idea how to find these stories? If you answered yes to any of these questions, then this book is for you. How Libraries Should Manage Data provides detailed instructions on how to transform your operational data from a fog of disconnected, unreliable, and inaccessible information - into an exemplar of best practice data management. Like the human brain, most people are only using a very small fraction of the true potential of Excel. Learn how to tap into a greater proportion of Excel's hidden power, and in the process transform your operational data into actionable business intelligence.

What does E=mc2 actually mean? Dr. Brian Cox and Professor Jeff Forshaw go on a journey to the frontier of twenty-first century science to unpack Einstein's famous equation. Explaining and simplifying notions of energy, mass, and light--while exploding commonly held misconceptions--they demonstrate how the structure of nature itself is contained within this equation. Along the way, we visit the site of one of the largest scientific experiments ever conducted: the now-famous Large Hadron Collider, a gigantic particle accelerator capable of re-creating conditions that existed fractions of a second after the Big Bang.

A collaboration between one of the youngest professors in the United Kingdom and a distinguished popular physicist, "Why Does E=mc2?" is one of the most exciting and accessible explanations of the theory of relativity.

By the star physicist and author of multiple #1 Sunday Times bestsellers, a major and definitive narrative work on black holes and how they can help us understand the universe.

At the heart of our galaxy lies a monster so deadly it can bend space, throwing vast jets of radiation millions of light years out into the cosmos. Its kind were the very first inhabitants of the universe, the black holes.

Today, across the universe, at the heart of every galaxy, and dotted throughout, mature black holes are creating chaos. And in a quiet part of the universe, the Swift satellite has picked up evidence of a gruesome death caused by one of these dark powers. High energy X-ray flares shooting out from deep within the Draco constellation are thought to be the dying cries of a white dwarf star being ripped apart by the intense tides of a supermassive black hole – heating it to millions of degrees as it is shredded at the event horizon.

They have the power to wipe out any of the universe’s other inhabitants, but no one has ever seen a black hole itself die. But 1.8 billion light years away, the LIGO instruments have recently detected something that could be the closest a black hole gets to death. Gravitational waves given off as two enormous black holes merge together. And now scientists think that these gravitational waves could be evidence of two black holes connecting to form a wormhole – a link through space and time. It seems outlandish, but today’s physicists are daring to think the unthinkable – that black holes could connect us to another universe.

At their very heart, black holes are also where Einstein’s Theory of General Relativity is stretched in almost unimaginable ways, revealing black holes as the key to our understanding of the fundamentals of our universe and perhaps all other universes.

Join Professors Brian Cox and Jeff Forshaw in exploring our universe’s most mysterious inhabitants, how they are formed, why they are essential components of every galaxy, including our own, and what secrets they still hold, waiting to be discovered.

A Brief History of Time for the 21st Century At the heart of our galaxy lies a monster so deadly, not even light can escape its grasp. Its secrets lie waiting to be discovered. It's time to explore our universe's most mysterious inhabitants Black Holes At the heart of the Milky Way lies a supermassive black hole 4 million times more massive than our Sun. A place where space and time are so warped that light is trapped if it ventures within 12 million km. According to Einstein, inside lies the end of time. According to 21st-century physics, the reality may be far more bizarre. Black holes lie where the most massive stars used to shine and at the edge of our current understanding. They are naturally occurring objects, the inevitable creations of gravity when too much matter collapses into not enough space. And yet, although the laws of nature predict them, they fail fully to describe them. Black holes are places in space and time where the laws of gravity, quantum physics and thermodynamics collide. Originally thought to be so intellectually troubling that they simply could not exist, it is only in the past few years that we have begun to glimpse a new synthesis; a deep connection between gravity and quantum information theory that describes a holographic universe in which space and time emerge from a network of quantum bits, and wormholes span the void. In this groundbreaking book, Professor Brian Cox and Professor Jeff Forshaw take you to the edge of our understanding of black holes; a scientific journey to the research frontier spanning a century of physics, from Einstein to Hawking and beyond, that ends with the startling conclusion that our world may operate like a giant quantum computer.

Every night, above our heads, a drama of epic proportions is playing out. Diamond planets, zombie stars, black holes heavier than a billion Suns. The cast of characters is extraordinary, and each one has its own incredible story to tell. We once thought of our Earth as unique, but we have now discovered thousands of alien planets, and that’s barely a fraction of the worlds that are out there. And there are more stars in the Universe than grains of sand on every planet in the Solar System. But amid all this vastness, the Milky Way Galaxy, our Sun and the Earth are home to the only known life in the Universe – at least for now. With a foreword from Professor Brian Cox, and access to all the latest stunning NASA photography, Andrew Cohen takes readers on a voyage of discovery, via the probes and telescopes exploring the outer reaches of our galaxy, revealing how it was formed and how it will inevitably be destroyed by the enigmatic black hole at its heart. And beyond our galaxy, the expanding Universe, which holds clues to the biggest mystery of all – how did it all begin? We now know more about those first moments of existence than we ever thought possible, and hidden in this story of how it all began are the clues to the fate of the Universe itself and everything in it.

This compilation is no mere collection of papers, but a well-edited collage of experiences in the transfer of library technical information, usually between developed and developing countries. Every continent is represented by a wealth of material; and the experiences discussed reflect both the variety of tasks handled by libraries and information centers and the diversity of the cultural milieux in which they operate. Original documents, case studies, analyses from third party observers-this rich collection provides a fascinating look at world development on the information frontier.

Every night, above our heads, a drama of epic proportions is playing out. Diamond planets, zombie stars, black holes heavier than a billion Suns. The cast of characters is extraordinary, and each one has its own incredible story to tell. We once thought of our Earth as unique, but we have now discovered thousands of alien planets, and that's barely a fraction of the worlds that are out there. And there are more stars in the Universe than grains of sand on every planet in the Solar System. But amid all this vastness, the Milky Way Galaxy, our Sun and the Earth are home to the only known life in the Universe - at least for now. With a foreword from Professor Brian Cox, and access to all the latest stunning NASA photography, Andrew Cohen takes readers on a voyage of discovery, via the probes and telescopes exploring the outer reaches of our galaxy, revealing how it was formed and how it will inevitably be destroyed by the enigmatic black hole at its heart. And beyond our galaxy, the expanding Universe, which holds clues to the biggest mystery of all - how did it all begin? We now know more about those first moments of existence than we ever thought possible, and hidden in this story of how it all began are the clues to the fate of the Universe itself and everything in it.

The leisure in which Brian Cox now writes his poems is hard-earned. Poetry, always his chief passion as reader and teacher, was forced to the edges of his life during the years in which he followed his other vocation in the world of education. When, shortly before his retirement in 1993, his "Collected Poems" appeared, it was clear that he had managed to write distinctive verse against the odds. His new collection has the freshness of a writer set free in a world which before contrained him. The presence of a physical universe, fulfilling all the senses, is palpable in his language; there is also an undercurrent of impassioned memory and what one critic called - in relation to this "Collected Poems" - "anticipatory elegy", the accepted knowledge of change and loss. There is an ambitious series of poems dedicated to writers and artists he admires: Saul Bellow, Chekhov, Van Gogh and Walter Benjamin.

Sunday Times Bestseller How did life on Earth begin? What is the nature of space and time? What are the chances that we will discover life on other worlds? Think you know our planet? Think again. Forces of Nature takes you from the mid-Atlantic ridge in Iceland, the volcanoes of Indonesia and the precipitous cliffs in Nepal, to the manatees off the coast of Florida and the northern lights of the Arctic, in search of the fundamental laws that govern our world. These universal laws shape everything, from the structure of snowflakes to the elegant spirals of the galaxies. By seeking to understand the everyday world - the colours, structure, behaviour and history of our home - we can step beyond the everyday and approach the Universe beyond.

Progress in Medicinal Chemistry, Volume 59, provides a review of eclectic developments in medicinal G139 chemistry. Each chapter is written by an international board of authors, with this release focusing on Small Molecules - Giant Leaps for Immuno-Oncology, Reviewing P2X7, Reviewing ASK1, and Reviewing DNA-encoded libraries.