First Published in 1997. Routledge is an imprint of Taylor & Francis, an informa company.

Themodernbillion-dollardrug-discoveryprocessstronglyreliesonbothhi- throughput synthesis and screening methods. Whereas the latter is based on molecular biological methods, the ef?cient and reliable generation of c- pound collections often makes use of combinatorial chemistry. Discovered in the 1980s, this methodology was explored extensively in the 1990s by groups in academia and in industry. Without any doubt, combinatorial chemistry changed the whole drug-discovery process and found many applications in cropscience and the material sciences. However, since its implementation, solution- and solid-phase techniques have been competing with each other, and although many companies started theircombinatorialchemistryprogramwithsolid-phasetechniques,soluti- phase combinatorial methods have taken over and now account for appro- mately 25% of all combinatorial efforts. The syntheses of complex, non-polymeric structures, discovered in the 1960s by the late Bruce Merri?eld, was largely ignored in the context of solid supports, mainly due to the fact that appropriate synthesis techniques were not available. Since solid-phase chemical methodology strongly differs from traditional solution-phase chemistry, two chapters deal with this topic. The Brase group (Jung, Wiehn, Brase) gives an overview of multifunctional linkers, which can beusedforthegenerationofdiversity-orientedcollections,simplybycleavage fromresins. Still in its infancy, solid-phase reactions employ "simple" amide chemistry in most cases due to their high-yielding, reliable protocols. Ljungdahl, Br- ?eld, and Kann address solid-phase organometallic chemistry, which is now one ofthe great challenges in reliable solid-phase organicsynthesis.

The Asian continent has a maritime tradition spanning as far back as the third millennium BC, and its port cities have for centuries had a social and cultural character radically different from those on the shores of the Atlantic. This book offers a fresh perspective on Asian history, focusing on the vital role played by ports and port cities.

1. D.M.P. Mingos, J.E. McGrady, A. L. Rohl Moments of Inertia in Cluster and Coordination Compounds 2. M. Drillon, J. Darriet Progress in Polymetallic Exchange-Coupled Systems, Some Examples in Inorganic Chemistry 3. P. Zanello Stereochemical Aspects Associated with the Redox Behaviour of Heterometal Carbonyl Clusters 4. R. G. Denning Electronic Structure and Bonding in Actinyl Ions 5. M. Evain, R. Brec ANew Approach to Structural Description of Complex Polyhedra Containing Polychalcogenide Anions 6. E. Brese, M. O'Keeffe Crystal Chemistry of Inorganic Nitrides

Themodernbillion-dollardrug-discoveryprocessstronglyreliesonbothhi- throughput synthesis and screening methods. Whereas the latter is based on molecular biological methods, the ef?cient and reliable generation of c- pound collections often makes use of combinatorial chemistry. Discovered in the 1980s, this methodology was explored extensively in the 1990s by groups in academia and in industry. Without any doubt, combinatorial chemistry changed the whole drug-discovery process and found many applications in cropscience and the material sciences. However, since its implementation, solution- and solid-phase techniques have been competing with each other, and although many companies started theircombinatorialchemistryprogramwithsolid-phasetechniques, soluti- phase combinatorial methods have taken over and now account for appro- mately 25% of all combinatorial efforts. The syntheses of complex, non-polymeric structures, discovered in the 1960s by the late Bruce Merri?eld, was largely ignored in the context of solid supports, mainly due to the fact that appropriate synthesis techniques were not available. Since solid-phase chemical methodology strongly differs from traditional solution-phase chemistry, two chapters deal with this topic. The Brase group (Jung, Wiehn, Brase) gives an overview of multifunctional linkers, which can beusedforthegenerationofdiversity-orientedcollections, simplybycleavage fromresins. Still in its infancy, solid-phase reactions employ "simple" amide chemistry in most cases due to their high-yielding, reliable protocols. Ljungdahl, Br- ?eld, and Kann address solid-phase organometallic chemistry, which is now one ofthe great challenges in reliable solid-phase organicsynthesis."

Dieser Band untersucht wichtige Stationen der Vor- und Fruhgeschichte der Aufklarung, zentrale Denker und Tendenzen der Aufklarungsepoche und deren Fortwirken. Es wird gezeigt, wie aufklarerische Impulse konzeptualisiert wurden und in Rezeption und Kritik mit aufklarungskritischen Positionen verflochten sind. Die Autoren rekonstruieren ursprungliche Entwurfe, Korrekturen und Uberbietungen und leisten so selbst eine Fortfuhrung der Aufklarung, indem die aufklarerische Vernunft mit Kritik angereichert und dadurch reflexiv eingeholt wird. Nur die uber ihre eigene Geschichte und ihre blinden Flecke aufgeklarte Vernunft kann der ursprunglichen Intention einer Emanzipation durch Kritik unter den komplexen Bedingungen der Gegenwart gerecht werden."

In dem Band werden neue Anforderungen in unterschiedlichen Handlungsfeldern beschrieben und diskutiert, die sich ganz grundsatzlich und zwangslaufig im Umgang mit Gefluchteten ergeben: Menschen mit traumatisierenden Erfahrungen benoetigen konkrete Hilfen, minderjahrige Gefluchtete mussen in Angeboten der Kinder- und Jugendhilfe aufgenommen werden, Rassismen, Stigmatisierungen und Diskriminierungen muss gerade von professioneller Seite reflektiert begegnet werden. Neben theoretischen Einordnungen zum Fluchtlingsdiskurs liefern die Beitrage Antworten auf aktuelle Fragen und entwickeln praxisrelevante Zugange zum Thema.

Die Tatsache, dass es die deutsche Sprache war, in der die nationalsozialistische Vernichtungspolitik erdacht, propagiert und mit beispielloser Effizienz durchgefuhrt wurde, hat - nicht nur unter UEberlebenden - nachhaltigen Zweifel daran geweckt, ob sie fortan noch als Medium poetischer Arbeit zu gebrauchen sei. Wenn das zentrale Moment poetischer Anstrengung darin bestand, "einer grossen humanen Sache zu dienen" (W. Hildesheimer) - konnte dies moeglich bleiben in einer Sprache, der jetzt die "Endloesung" unabtrennbar zugehoerte? Wie deutschsprachige Autoren auf diese Herausforderung reagiert haben, steht im Mittelpunkt der in diesem Band versammelten Untersuchungen von Wissenschaftlern aus Israel, Deutschland und der Schweiz.

In diesem Band wird nachgewiesen, wie sich die satirische Gattung in der Auseinandersetzung mit dem NS-Faschismus und gegen erheblichen Widerstand im Exil radikalisiert: Sie wird zu einem Blick des Lesers auf sich selbst und zu einer illusionslosen Neuformulierung der Schuldfrage. Verschiedene Fallstudien - etwa zu Werken Klaus Manns, Irmgard Keuns, Bertolt Brechts - zeichnen diese Entwicklung genau nach und belegen, wie diese Radikalisierung des Satirischen schliesslich auch - uber Edgar Hilsenraths Groteske "Der Nazi & der Friseur" - Eingang in die deutsche Gegenwartsliteratur gefunden hat."

I hope this book brings comfort to those who lost a beloved pet. It brought me comfort when I got a full bodied apparition of my cat and two geese. This book contains spirit photos of my cat, other cats, a couple of our geese and other animals that either were or were not a pet, depending on the picture. Because the cost of making of a photo book is high, I omitted many pictures and put them on a web page. The link to this web page is inside the book. Two or three pages say "picture below" when it should have been "on next page". So you are not missing any pictures. In the original manuscript, the pictures were above and below each other, in book form, of course, they are on next and previous page. As Amazon charges more than the printer of the book; I suggest that if you're interested in this book; you get it for a little cheaper at: http://www.lulu.com/spotlight/Jb1961

'The Hidden Story - The Poetry of Jeff Bresee' is a compilation of poems of varying types and themes that were inspired by the author's life long struggle with mental illness and addiction, and his determination to conquer these vises by his firm belief in God and family. The Hidden Story tells the tales that are familiar to all; what lies beneath the masks that we wear, and what deep inner struggles exist in the hearts and minds of those who refuse to give up.

Clyde Bresee was just five years old in 1921 when his family moved from a tiny Pennsylvania farm to the Lawton Plantation near Charleston, South Carolina. While his father labored for the next decade to revitalize the sprawling sea island plantation's dairy operation, Clyde reveled in a world utterly foreign from the community of his birth; he encountered a society of mannered gentility, a climate in which winter passed in a twinkling of an eye, a place of wandering tidal streams and vast expanses of salt marshes, and a people - African-American people - he had never met. In Sea Island Yankee, Bresee revisits the time and place that endowed his childhood with great happiness and have held a powerful grip on his adult musings. With the observant eyes of a youngster and the distanced perspective of an outsider, Bresee re-creates his boyhood world of water, live oaks, and Spanish moss. He recalls Confederate memorial observances at which he heard white-haired veterans recount Civil War battles, and he chronicles seemingly endless opportunities for swimming, crabbing, boating, and exploring. Bresee also pays tribute to the unforgettable African Americans who shaped his sea island experience, from Jamsie, his multi-talented playmate, to Ned, the indispensable plantation employee who once saved the life of Clyde's brother. Enhanced by charming illustrations, Bresee's beautifully crafted account captures the adventures of a wondrous boyhood and the character of a remarkable sea island community.