This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

Drawing together insights from media studies, sociology and science and technology studies, this book is one of the first major studies of media coverage, policy debates and public perceptions of nanotechnologies, and makes a fascinating and timely contribution to debates about the public communication of science.

With the increasing linguistic and cultural diversity of students in U. S. schools, all teachers, regardless of the content area or grade they teach, need research-based strategies for assisting all students to gain English proficiency. This practical, concise guide shows teachers what they need to know about language, how it is learned, how it is used, and how teaching about it can be incorporated into lessons throughout the curriculum.

Understanding Language in Diverse Classrooms offers a model of how learning takes place and describes the critical role of teachers in that model. It includes comparison charts showing how some of the most common heritage languages represented among present-day students compare with English, and it provides examples of hands-on materials including checklists, rating scales, and sample lessons to help teachers prepare to teach all their students in diverse classrooms. Each chapter ends with questions to stimulate discussion and reflection on major chapter points, to enable readers to review and evaluate the information and then integrate it into their own practice.

This work reviews recent developments in the field of workplace health from a practical point of view. It is aimed at managers and health specialists concerned with initiating new policies to develop and improve workplace health. The book provides guidance in managing health at work, gives specific examples of good practice and alerts the reader to relevant guidelines surrounding issues such as stress, cancer, HIV and AIDS, RSI, healthy eating and exercise. The author argues that increasing attention should be paid to the use of workplace health especially with the growing number of employees making claims against their employers for a wide range of health problems. The book includes: examples of good practice in the field of workplace health; identification of the role of the manager in improving health in the workplace; and description of the latest research into prevention of high-profile health complaints. The book should be a useful tool for health promotion specialists and managers with personnel and human resources responsibilities, and students involved in undergraduate and postgraduate studies in occupational health, health promotion and managing health; health promotion s

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

With the increasing linguistic and cultural diversity of students in U. S. schools, all teachers, regardless of the content area or grade they teach, need research-based strategies for assisting all students to gain English proficiency. This practical, concise guide shows teachers what they need to know about language, how it is learned, how it is used, and how teaching about it can be incorporated into lessons throughout the curriculum.

Understanding Language in Diverse Classrooms offers a model of how learning takes place and describes the critical role of teachers in that model. It includes comparison charts showing how some of the most common heritage languages represented among present-day students compare with English, and it provides examples of hands-on materials including checklists, rating scales, and sample lessons to help teachers prepare to teach all their students in diverse classrooms. Each chapter ends with questions to stimulate discussion and reflection on major chapter points, to enable readers to review and evaluate the information and then integrate it into their own practice.

With a focus on what mathematics and science educators need to know about academic language used in the STEM disciplines, this book critically synthesizes the current knowledge base on language challenges inherent to learning mathematics and science, with particular attention to the unique issues for English learners. These key questions are addressed: When and how do students develop mastery of the language registers unique to mathematics and to the sciences? How do teachers use assessment as evidence of student learning for both accountability and instructional purposes? Orienting each chapter with a research review and drawing out important Focus Points, chapter authors examine the obstacles to and latest ideas for improving STEM literacy, and discuss implications for future research and practice.

With a focus on what mathematics and science educators need to know about academic language used in the STEM disciplines, this book critically synthesizes the current knowledge base on language challenges inherent to learning mathematics and science, with particular attention to the unique issues for English learners. These key questions are addressed: When and how do students develop mastery of the language registers unique to mathematics and to the sciences? How do teachers use assessment as evidence of student learning for both accountability and instructional purposes? Orienting each chapter with a research review and drawing out important Focus Points, chapter authors examine the obstacles to and latest ideas for improving STEM literacy, and discuss implications for future research and practice.

This volume explores the part played by different metals in use from the fourth millennium BC to the Early Iron Age, not only in the Aegean but also in the wider Old World. It addresses the divergent uses and roles of different metals, the interrelationships of these roles and the changing values that may have been accorded to them at different times and in different places by producers and consumers. Individually, the papers in the volume contemplate the particular properties of different metals and the various issues concerning their frequent under-representation in the archaeological (but not necessarily textual) record, and also point out comparative and diachronic perspectives that may have the ability to offer insights into their important roles in wider cultural and historical changes over a period of several millennia. After the Introduction and Chapter 1, which reflects on some of the parameters involved in the term ‘precious’ as applied to metals, the remaining six chapters cover the Aegean and the networks that link the Aegean with Italy, Cyprus and the Near East more generally, and south-east Anatolia and the Caucasus. Between them they discuss the beginnings of regular iron metallurgy, the uses of and attitudes to gold, silver and bronze and other copper-based alloys at various times between the fourth millennium BC and the Early Iron Age.

The rapid progress in clinical and experimental immunological research, in addition to the radical change in immunological concepts in recent years, has been accompanied by similar developments in the technical vocabulary, and, as a consequence, frequent widespread confusion. The fourth edition of The Dictionary of Immunology will satisfy the needs of any biologist, clinician or biochemist who requires easy reference to current immunological usage.
This well-established work has been completely revised and updated to include key terms arising from new discoveries in the fast-developing fields of molecular and cellular immunology. The Dictionary of Immunology contains brief descriptions of the most commonly used immunological techniques, as well as definitions, useful in clinical immunology, of immunodeficiency states and autoimmune diseases. Clear illustrations and tables have been added to complement the text, and extensive cross-referencing is used to inform an integrated view.
The Dictionary will serve equally as a handy reference, a companion to other reference texts, or a spelling and fact checker for students, research scientists and those engaged in ancillary activities such as science journalists, and the curious lay reader.
* Special Features:
* Radical revision, including addition of 30% new terms.

Ibadism represents a branch of the third great division in Islam, that of the Khawarij. It survives in some isolated communities in North Africa, but manifested itself periodically in Oman as a full Imamate well into the twentieth century.
Using early material recorded in Basran and Omani sources, this book deconstructs the standard account of origins, showing that Ibadism's evolution into a madhhab (school) can only be understood in a wider historical perspective of the tribal and regional dimensions. Its activation among the Yamani tribes of Iraq requires reappraising what the Yaman-Nizar division represented in the Umayyad period, and the opening chapters demonstrate that there was a real split in pre-Islamic times between northern and southern Arabs that was reflected in the great revolts of Ibn al-As'ath al-Kindi and Yazid b. al-Muhallab al-Azdi. The nascent Ibadi movement in Basra, whose solidarity was enshrined in walaya, the spiritual and physical cement binding the community to God, exploited the resulting resentment to establish Imamates in southern Arabia, followed by North Africa. Study of the earliest sources throws considerable light not only on Ibadi origins, but also the early emergence of Islamic kalam and fiqh and the influence of contemporary theological debate.
The history of Ibadism in the first six Islamic centuries is essential for understanding both the evolution of institutions and practical law. One of is strengths is the ability to adapt to different situations, and the pragmatic rulings concerning agriculture, trade, mining, and in the case of Oman, its major role in expanding Indian Ocean commerce represents a unique maritime legal code. In parallel comes an increasing convergence towards Sunni-Ash'ari norms and the evolution of Ibadi identity as a madhhab. Sunna and hadith were absorbed into the athar of the community, which now develops as a formal line of transmission and even the production of their own hadith collection in the Maghrib. Nevertheless, interpretation still remained essentially open, thus giving the system a flexibility that ensured survival in widely different environments.

This comprehensive volume describes evidence-based strategies for supporting English language learners (ELLs) by promoting meaningful communication and language use across the curriculum. Leading experts explain how and why learning is different for ELLs and pinpoint specific best practices for the classroom, illustrated with vivid examples. Particular attention is given to ways in which learning English is intertwined with learning the student's home language. The book addresses both assessment and instruction for typically developing ELLs and those with language disabilities and disorders. It demonstrates how educators and speech-language professionals can draw on students' linguistic, cognitive, sociocultural, and family resources to help close the achievement gap. This title is part of the Social Work Practice With Children and Families Series, edited by Nancy Boyd Webb.

This comprehensive volume describes evidence-based strategies for supporting English language learners (ELLs) by promoting meaningful communication and language use across the curriculum. Leading experts explain how and why learning is different for ELLs and pinpoint specific best practices for the classroom, illustrated with vivid examples. Particular attention is given to ways in which learning English is intertwined with learning the student's home language. The book addresses both assessment and instruction for typically developing ELLs and those with language disabilities and disorders. It demonstrates how educators and speech-language professionals can draw on students' linguistic, cognitive, sociocultural, and family resources to help close the achievement gap.

Updated and enhanced, the second edition of this text provides both library students and practitioners with a thorough understanding of procedural and philosophical approaches in acquisitions management. Since the last edition of this text was published over a decade ago, library acquisitions practices have changed dramatically in response to economic and industry changes and the introduction and maturation of new technologies. An essential tool kit, this updated edition covers every aspect of current acquisitions management from organization of acquisitions departments to professional ethics. The step-by-step guide takes you through acquisitions department activities from the beginning of the ordering process through making materials available to the public. You'll learn about the latest acquisitions systems, negotiating bids and RFPs, gifts and exchange, and decisions of permanence. In addition, the book provides expert guidance on relationships with vendors as well as on the publishing industry in general. Key among the updates to this second edition is information about major changes that have occurred recently, including what's new in integrated library systems, electronic resource management, and patron- and demand-driven acquisitions. An appendix offers a wealth of resources on topics related to acquisitions and includes a comprehensive glossary. Incorporates thoroughly updated information that reflects today's fast-changing world of acquisitions management and addresses the changing landscape of publishing overall Highlights new web-based materials Takes an integrated approach to acquisitions functions and operations Serves as both a manual for practicing acquisitions librarians and support staff and as a textbook for students in library and information science programs

Title: Trial of Judge Wilkinson, Dr. Wilkinson, and Mr. Murdaugh: on indictments for the murder of John Rothwell and Alexander H. Meeks in an affray which occurred at the Galt House, Louisville, Ky., on the 15th of December 1838.Author: Edward C WilkinsonPublisher: Gale, Sabin Americana Description: Based on Joseph Sabin's famed bibliography, Bibliotheca Americana, Sabin Americana, 1500--1926 contains a collection of books, pamphlets, serials and other works about the Americas, from the time of their discovery to the early 1900s. Sabin Americana is rich in original accounts of discovery and exploration, pioneering and westward expansion, the U.S. Civil War and other military actions, Native Americans, slavery and abolition, religious history and more.Sabin Americana offers an up-close perspective on life in the western hemisphere, encompassing the arrival of the Europeans on the shores of North America in the late 15th century to the first decades of the 20th century. Covering a span of over 400 years in North, Central and South America as well as the Caribbean, this collection highlights the society, politics, religious beliefs, culture, contemporary opinions and momentous events of the time. It provides access to documents from an assortment of genres, sermons, political tracts, newspapers, books, pamphlets, maps, legislation, literature and more.Now for the first time, these high-quality digital scans of original works are available via print-on-demand, making them readily accessible to libraries, students, independent scholars, and readers of all ages.++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++SourceLibrary: Huntington LibraryDocumentID: SABCP03718300CollectionID: CTRG01-B2992PublicationDate: 18390101SourceBibCitation: Selected Americana from Sabin's Dictionary of books relating to AmericaNotes: Two columns to the page. Trial held in Circuit Court of Mercer County, Ky.: cf. p. 5]Collation: 139 p.; 23 cm

This comprehensive presentation of the Request for Proposal (RFP) process shows librarians how to successfully prepare RFPs when determining which vendors to use for purchasing library materials. Contending that the straight bid process, where only costs and discount rates are considered, does not offer the best options for libraries, the authors provide information on every facet of the RFP process--from philosophical and pragmatic reasons for writing an RFP to evaluation of responses and awarding of contracts to transferring titles and evaluation of vendor services and products. All of the material in this book can be transferred to any kind of RFP for any kind of library materials. Special features include chapters on the acquisition of specialized materials (e.g., science, technology, fine arts) and foreign materials, and specific information on electronic/automated services. Appendixes contain samples of the cover letter, questions for various sections and types of RFPs, and evaluation criteria

This comprehensive book covers the philosophy behind RFPs to prime readers to understand how to most effectively write them and provides instruction on navigating the submission process as it applies to multiple types of libraries. For many years, only large academic and public libraries and a few library systems regularly used RFPs. Now, smaller schools, public libraries, and library systems use RFPs as tools to select vendors for computer equipment, online systems, databases, and materials. Library consortia frequently use RFPs to select databases and integrated library systems. In this useful book, readers will learn more about the types and advantages of RFPs; the timelines and logistics for submitting RFPs; how to write different types of RFPs; how to evaluate vendor performance; the transfer process when a new vendor is selected; vendor perspectives; and RFP ethics. An appendix includes sample RFPs and evaluation materials, and a glossary defines language necessary to writing and understanding RFPs. This book is essential reading for librarians who need to select vendors to provide library materials including books, serials, and media in all formats as well as for those who are choosing integrated library systems, security and inventory systems such as RFID, computer equipment and software, online and streaming materials such as books and music, or services such as digitization. Teaches readers how to acquire an appropriate product from a vendor at the lowest price Provides practical examples of questions to use in various RFPs as well as lessons learned Includes sample RFPs and evaluation materials Incorporates perspectives of librarians and vendors with experience in various aspects of the RFP process