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This book is a treatise on cardiomyocytes, the most important cell
for the contractile function of the heart. There has been
significant progress in our understanding of the function-related
structure, developmental processes and their determinants,
mechanisms of cell cycle regulation, post-natal growth, energy
metabolism, and reversible and irreversible response of
cardiomyocytes to diverse forms of physiological stress and injury.
There is also more clarity on the alterations in the biological
mechanisms in cardiomyocytes that lead to pathological states and
the changes in the cells that occur secondary to disease
conditions. Thanks to these advances in knowledge, there have been
great gains in attempts to identify disease biomarkers and
therapeutic targets for better management of patients with heart
diseases. Possibilities to induce regeneration or proliferation of
cardiomyocytes and thus repair and or regenerate the damaged heart
are also on the horizon.
This book is a treatise on cardiomyocytes, the most important cell
for the contractile function of the heart. There has been
significant progress in our understanding of the function-related
structure, developmental processes and their determinants,
mechanisms of cell cycle regulation, post-natal growth, energy
metabolism, and reversible and irreversible response of
cardiomyocytes to diverse forms of physiological stress and injury.
There is also more clarity on the alterations in the biological
mechanisms in cardiomyocytes that lead to pathological states and
the changes in the cells that occur secondary to disease
conditions. Thanks to these advances in knowledge, there have been
great gains in attempts to identify disease biomarkers and
therapeutic targets for better management of patients with heart
diseases. Possibilities to induce regeneration or proliferation of
cardiomyocytes and thus repair and or regenerate the damaged heart
are also on the horizon.
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