It was not too many years ago that the role of chemotherapy for head and neck cancer consisted of single-agent methotrexate for selected patients with recurrent disease. In the past decade, multiple new agents, high-dose chemotherapy, combinations, and intra-arterial approaches have been used for the patient with recurrent disease. Wheeler critically assesses the current status of these approaches. When oncologists began testing chemotherapy in the combined modality approach, trials consisted of induction chemotherapy and use of single agents as radiosensitizers. Although a great deal has been learned from these trials, benefit in terms of survival has been marginal. Even more promising may be the concomitant use of combination chemo therapy and radiation. Taylor describes the encouraging results as well as the potential. Induction chemotherapy may have a second important goal in addition to improving curability-it could be used for organ preservation. Dimery et al., present the background for this approach in the patient with laryngeal cancer as well as a description of their randomized trial for voice preservation. Head and neck squamous cancers are a heterogeneous group of diseases, and surgeons have long sought parameters that will help predict outcome."

Cancers of the head and neck are among the most morbid of cancers. Convention al surgery and/or radiation therapy have a high cure rate for patients with early stage disease. However, despite optimal treatment with surgery and radiotherapy, patients with nodal spread or extensive local disease have a low cure rate. Even if a cancer is cured, a patient is often left with long-term debilities from the treatment and/or cancer. The major causes for decreased survival in patients with advanced head and neck cancer include local recurrence, distant metastases, and second primaries. All of these need to be addressed if one is to improve upon the curability of advanced disease. There are several new techniques, surgical and radiotherapeutic, designed to improve local control. Brachytherapy, or interstitial implantation, delivers a high dose of localized radiation with minimal normal tissue injury. This technique as discussed by Goffinet, may be even more efficacious when combined with hyperthermia. New, creative methods of radiation therapy delivery, such as the use of multiple fractions per day, as discussed by Parsons and Million, are also contributing to long-term local control. Laser therapy, discussed by Ossoff and Nemeroff, provides another tool for treatment of local disease."

In the 1950s, ninety-five percent of patients with Hodgkin's disease, a cancer of lymph tissue which afflicts young adults, died. Today most are cured, due mainly to the efforts of Dr. Henry Kaplan. "Henry Kaplan and the Story of Hodgkin's Disease" explores the life of this multifaceted, internationally known radiation oncologist, called a "saint" by some, a "malignant son of a bitch" by others. Kaplan's passion to cure cancer dominated his life and helped him weather the controversy that marked each of his innovations, but it extracted a high price, leaving casualties along the way. Most never knew of his family struggles, his ill-fated love affair with Stanford University, or the humanitarian efforts that imperiled him.
Today, Kaplan ranks as one of the foremost physician-scientists in the history of cancer medicine. In this book Charlotte Jacobs gives us the first account of a remarkable man who changed the face of cancer therapy and the history of a once fatal, now curable, cancer. She presents a dual drama --the biography of this renowned man who called cancer his "Moby Dick" and the history of Hodgkin's disease, the malignancy he set out to annihilate. The book recounts the history of Hodgkin's disease, first described in 1832: the key figures, the serendipitous discoveries of radiation and chemotherapy, the improving cure rates, the unanticipated toxicities. The lives of individual patients, bold enough to undergo experimental therapies, lend poignancy to the successes and failures.
Visit the author's website.

In the 1950s, ninety-five percent of patients with Hodgkin's disease, a cancer of lymph tissue which afflicts young adults, died. Today most are cured, due mainly to the efforts of Dr. Henry Kaplan. "Henry Kaplan and the Story of Hodgkin's Disease" explores the life of this multifaceted, internationally known radiation oncologist, called a "saint" by some, a "malignant son of a bitch" by others. Kaplan's passion to cure cancer dominated his life and helped him weather the controversy that marked each of his innovations, but it extracted a high price, leaving casualties along the way. Most never knew of his family struggles, his ill-fated love affair with Stanford University, or the humanitarian efforts that imperiled him.
Today, Kaplan ranks as one of the foremost physician-scientists in the history of cancer medicine. In this book Charlotte Jacobs gives us the first account of a remarkable man who changed the face of cancer therapy and the history of a once fatal, now curable, cancer. She presents a dual drama --the biography of this renowned man who called cancer his "Moby Dick" and the history of Hodgkin's disease, the malignancy he set out to annihilate. The book recounts the history of Hodgkin's disease, first described in 1832: the key figures, the serendipitous discoveries of radiation and chemotherapy, the improving cure rates, the unanticipated toxicities. The lives of individual patients, bold enough to undergo experimental therapies, lend poignancy to the successes and failures.
Visit the author's website.

Women continue to be underrepresented in the high paying fields of science, math, and engineering. They receive only about 80% of the salary of men holding similar jobs in any field and still face glass ceilings that limit their attainment. How do we educate and empower girls to surmount these barriers and succeed throughout their lives? This unique book reveals the kinds of teaching that engages girls intellectually, fosters their creativity, and bolsters their confidence. Drawing on descriptions of great lessons written by nearly 2,000 students and teachers, it offers a practical, accessible guide to anyone who wants to find better ways to help young women succeed. The authors review the special qualities of lessons that resonate with girls and show how they meet their developmental needs throughout adolescence. They also show how vital it is that such teaching happen within schools that help students learn about the numerous ways that gender affects girls' development. The authors conclude by detailing how school leaders can create cultures that support this kind of great learning and teaching.

Women continue to be underrepresented in the high paying fields of science, math, and engineering. They receive only about 80% of the salary of men holding similar jobs in any field and still face glass ceilings that limit their attainment. How do we educate and empower girls to surmount these barriers and succeed throughout their lives? This unique book reveals the kinds of teaching that engages girls intellectually, fosters their creativity, and bolsters their confidence. Drawing on descriptions of great lessons written by nearly 2,000 students and teachers, it offers a practical, accessible guide to anyone who wants to find better ways to help young women succeed. The authors review the special qualities of lessons that resonate with girls and show how they meet their developmental needs throughout adolescence. They also show how vital it is that such teaching happen within schools that help students learn about the numerous ways that gender affects girls' development. The authors conclude by detailing how school leaders can create cultures that support this kind of great learning and teaching.

While figures on Black women and girls' degree attainment suggest that as a group they are achieving in society, the reality is that their experiences are far from monolithic, that the educational system from early on and through college imposes barriers and inequities, pushing many out of school, criminalizing their behavior, and leading to a high rate of incarceration. The purpose of this book is to illuminate scholarship on Black women and girls throughout the educational pipeline. The contributors--all Black women educators, scholars, and advocates--name the challenges Black women and girls face while pursuing their education as well as offer implications and recommendations for practitioners, policymakers, teachers, and administrators to consider in ensuring the success of Black women and girls. This book is divided into four sections, each identifying the barriers Black girls and women encounter at the stages of their education and offering strategies to promote their success and agency within and beyond educational contexts. In Part One, the contributors explore the importance of mattering for Black girls in terms of redefining success and joy; centering Black girl literacy pedagogies that encourage them to thrive; examining how to make STEM more accessible to them; and recounting how Black girls' emotions and emotional literacy can either disempower them or promote their sense of agency to navigate educational contexts. Part Two uncovers the violence directed toward and the criminalization of Black women and girls, and how they are situated in educational and justice systems that collude to fail them. The contributors address incarceration and the process of rehabilitation and reentry; the outcomes of disciplinary action in schools on women who pursue college; and describe how the erasure and disregard of Black women and girls leaves them absent from the educational policies that deeply affect their lives and wellbeing. Part Three focuses on how Black women are left to navigate without resources that could make their collegiate pathways smoother; covers how hair politics impact their acceptance in college leadership roles, particularly at HBCUs; illuminates the importance of social/emotional and mental health for Black undergraduate women and the lack of adequate resources; and explores how women with disabilities navigate higher education. The final part of this book describes transformative approaches to supporting the educational needs of Black women and girls, including the use of a politicized ethic of care, intergenerational love and dialogue, and constructing communities, including digital environments, to ensure they thrive through their education and beyond.

While figures on Black women and girls' degree attainment suggest that as a group they are achieving in society, the reality is that their experiences are far from monolithic, that the educational system from early on and through college imposes barriers and inequities, pushing many out of school, criminalizing their behavior, and leading to a high rate of incarceration. The purpose of this book is to illuminate scholarship on Black women and girls throughout the educational pipeline. The contributors--all Black women educators, scholars, and advocates--name the challenges Black women and girls face while pursuing their education as well as offer implications and recommendations for practitioners, policymakers, teachers, and administrators to consider in ensuring the success of Black women and girls. This book is divided into four sections, each identifying the barriers Black girls and women encounter at the stages of their education and offering strategies to promote their success and agency within and beyond educational contexts. In Part One, the contributors explore the importance of mattering for Black girls in terms of redefining success and joy; centering Black girl literacy pedagogies that encourage them to thrive; examining how to make STEM more accessible to them; and recounting how Black girls' emotions and emotional literacy can either disempower them or promote their sense of agency to navigate educational contexts. Part Two uncovers the violence directed toward and the criminalization of Black women and girls, and how they are situated in educational and justice systems that collude to fail them. The contributors address incarceration and the process of rehabilitation and reentry; the outcomes of disciplinary action in schools on women who pursue college; and describe how the erasure and disregard of Black women and girls leaves them absent from the educational policies that deeply affect their lives and wellbeing. Part Three focuses on how Black women are left to navigate without resources that could make their collegiate pathways smoother; covers how hair politics impact their acceptance in college leadership roles, particularly at HBCUs; illuminates the importance of social/emotional and mental health for Black undergraduate women and the lack of adequate resources; and explores how women with disabilities navigate higher education. The final part of this book describes transformative approaches to supporting the educational needs of Black women and girls, including the use of a politicized ethic of care, intergenerational love and dialogue, and constructing communities, including digital environments, to ensure they thrive through their education and beyond.

Cancers of the head and neck are among the most morbid of cancers. Convention al surgery and/or radiation therapy have a high cure rate for patients with early stage disease. However, despite optimal treatment with surgery and radiotherapy, patients with nodal spread or extensive local disease have a low cure rate. Even if a cancer is cured, a patient is often left with long-term debilities from the treatment and/or cancer. The major causes for decreased survival in patients with advanced head and neck cancer include local recurrence, distant metastases, and second primaries. All of these need to be addressed if one is to improve upon the curability of advanced disease. There are several new techniques, surgical and radiotherapeutic, designed to improve local control. Brachytherapy, or interstitial implantation, delivers a high dose of localized radiation with minimal normal tissue injury. This technique as discussed by Goffinet, may be even more efficacious when combined with hyperthermia. New, creative methods of radiation therapy delivery, such as the use of multiple fractions per day, as discussed by Parsons and Million, are also contributing to long-term local control. Laser therapy, discussed by Ossoff and Nemeroff, provides another tool for treatment of local disease."

It was not too many years ago that the role of chemotherapy for head and neck cancer consisted of single-agent methotrexate for selected patients with recurrent disease. In the past decade, multiple new agents, high-dose chemotherapy, combinations, and intra-arterial approaches have been used for the patient with recurrent disease. Wheeler critically assesses the current status of these approaches. When oncologists began testing chemotherapy in the combined modality approach, trials consisted of induction chemotherapy and use of single agents as radiosensitizers. Although a great deal has been learned from these trials, benefit in terms of survival has been marginal. Even more promising may be the concomitant use of combination chemo therapy and radiation. Taylor describes the encouraging results as well as the potential. Induction chemotherapy may have a second important goal in addition to improving curability-it could be used for organ preservation. Dimery et al., present the background for this approach in the patient with laryngeal cancer as well as a description of their randomized trial for voice preservation. Head and neck squamous cancers are a heterogeneous group of diseases, and surgeons have long sought parameters that will help predict outcome."