Arti?cial intelligence (AI) is a dynamic ?eld that is constantly expanding into new application areas, discovering new research challenges, and facilitating the development of innovative products. Today's AI tools might not pass the Turing test, but they are invaluable aids in organizing and sorting the ever-increasing volume, complexity, andheterogeneityofknowledgeavailabletousinourrapidly changing technological, economic, cultural, and social environment. This volumeaimsatbringing to the readerallthe latest developmentsin this exciting and challenging ?eld, and contains papers selected for presentation at the 6th Hellenic Conference on Arti?cial Intelligence (SETN 2010), the o?cial meeting of the Hellenic Society for Arti?cial Intelligence (EETN). SETN 2010 was organized by the Hellenic Society of Arti?cial Intelligence and the Institute of Informatics and Telecommunications, NCSR 'Demokritos' and took place in Athens during May 4-7.Previousconferences were held at the University of Piraeus (1996), at the Aristotle University of Thessaloniki (2002), attheUniversityoftheAegean(Samos,2004, andSyros,2008), andjointlyatthe Foundation for Research and Technology-Hellas (FORTH) and the University of Crete (2006). SETN conferences play an important role in disseminating innovative and high-qualityscienti?c results by AI researchers, attractingnot only EETNm- bers but also scientists advancing and applying AI in many and diverse domains and from various Greek and international institutes. However, the most imp- tant aspect of SETN conferences is that they provide the context in which AI researchers meet and discuss their work, as well as an excellect opportunity for students to attend high-quality tutorials and get closer to AI results.