This book constitutes the refereed proceedings of the 10th International Conference on Smart Homes and Health Telematics, ICOST 2012, held in Artiminio, Tuscany, Italy, June 12- 15, 2012. The 25 revised full papers presented together with 22 short papers were carefully reviewed and selected from 74 submissions. The papers are categorized into a number of sessions that include: User Engagement for Improved Adoption of Assistive Technologies, Self-Management and Tele-Rehabilitation, Advances in Remote Monitoring and Activity Recognition, Sensor Networks for Unobstrusive Monitoring Solutions, and Real World "Aware" Systems.