A commiserating and provocative tale, Primacy is an all-important lesson of love, tragedy and inspiration as told from an urban perspective. Propagated in the latter portion of the turbulent 60's, on the outskirts of the gritty streets of Philadelphia, it is the story of a young male born in a 'dysfunctional' household and living in a less than opulent neighborhood. With an adolescent's cognizant awareness of the times and personal events, the prognosticator's life starts out on an anger-laced, emotionally charged tumultuous journey that eventually transcends both the time and the streets of the "City of Brotherly Love." Later in the story as the prognosticator becomes of age you are escorted further into his moral decadence as he takes the reader descriptively fitting into the twenty-first century, meeting with consequences and humility. Eloquently written with appropriate vernacular and speech of the situational characters, this story brings into stark visualization a vivid visitation for the reader. Primacy is an empathetic journey for the many whom have felt that they have been through trying situations and that no other soul could possibly empathize.

This volume is a wide-ranging tool for studying protein-carbohydrate interactions that extend from traditional biochemical methods to state-of-the-art techniques. This book focuses on four different research themes: Part I describes methods for screening and quantifying CAZyme activity; Part II contains methods for investigating the interactions between proteins and carbohydrate ligands; Part III discusses methods for the visualization of carbohydrates and protein-carbohydrate complexes; and Part IV focuses on structural and "omic" approaches for studying systems of CAZymes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Protein-Carbohydrate Interactions: Methods and Protocols is a valuable resource to the glycomics research community. In this continuously advancing field, the methods in this book highlight the biology of glycomics, thus driving biotechnological innovation and solutions for human health and sustainable resources within the emerging green community.

This is the first book to describe the entire developmental history of the human aspects of economics. The issue of "self-interest" is discussed throughout, from pre-Adam Smith to contemporary neuroeconomics, representing a unique contribution to economics. Though the notion of self-interest has been interpreted in several ways by various schools of economics and economists since Smith first placed it at the heart of the field, this is the first book to focus on this important but overlooked topic. Traditionally, economic theory has presupposed that the core of human behavior is self-interest. Nevertheless, some economists, e.g. recent behavioral economists, have cast doubt on this "self-interested" explanation. Further, though many economists have agreed on the central role of self-interest in economic behavior, each economist's positioning of self-interest in economic theory differs to some degree. This book helps to elucidate the position of self-interest in economic theory. Given its focus, it is a must-read companion, not only on the history of economic thought but also on economic theory. Furthermore, as today's capitalism is increasingly causing people to wonder just where self-interest lies, it also appeals to general readers.

This book seeks to advance social economic analysis, economic methodology, and the history of economic thought in the context of twenty-first-century scholarship and socio-economic concerns. Bringing together carefully selected chapters by leading scholars it examines the central contributions that John Davis has made to various areas of scholarship. In recent decades, criticisms of mainstream economics have rekindled interest in a number of areas of scholarly inquiry that were frequently ignored by mainstream economic theory and practice during the second half of the twentieth century, including social economics, economic methodology and history of economic thought. This book contributes to a growing literature on the revival of these areas of scholarship and highlights the pivotal role that John Davis's work has played in the ongoing revival. Together, the international panel of contributors show how Davis's insights in complexity theory, identity, and stratification are key to understanding a reconfigured economic methodology. They also reveal that Davis's willingness to draw from multiple academic disciplines gives us a platform for interrogating mainstream economics and provides the basis for a humane yet scientific alternative. This unique volume will be essential reading for advanced students and researchers across social economics, history of economic thought, economic methodology, political economy and philosophy of social science.

This book seeks to advance social economic analysis, economic methodology, and the history of economic thought in the context of twenty-first-century scholarship and socio-economic concerns. Bringing together carefully selected chapters by leading scholars it examines the central contributions that John Davis has made to various areas of scholarship. In recent decades, criticisms of mainstream economics have rekindled interest in a number of areas of scholarly inquiry that were frequently ignored by mainstream economic theory and practice during the second half of the twentieth century, including social economics, economic methodology and history of economic thought. This book contributes to a growing literature on the revival of these areas of scholarship and highlights the pivotal role that John Davis's work has played in the ongoing revival. Together, the international panel of contributors show how Davis's insights in complexity theory, identity, and stratification are key to understanding a reconfigured economic methodology. They also reveal that Davis's willingness to draw from multiple academic disciplines gives us a platform for interrogating mainstream economics and provides the basis for a humane yet scientific alternative. This unique volume will be essential reading for advanced students and researchers across social economics, history of economic thought, economic methodology, political economy and philosophy of social science.

Patrick Suppes (1922-2014) was an extraordinarily wide-ranging scholar. Although best known as a philosopher of science, Suppes made substantial contributions to a remarkably wide range of different fields of research including many relevant to economics: decision theory, philosophy of economics, modeling theory, foundations of measurement, philosophy of psychology (and thus what is now behavioral economics), and many other fields. This collection recognizes Suppes's contributions to economics and economic methodology with a symposium of papers that examine, build on, and/or assess Suppes's research in these areas. The authors include philosophers, economists, game theorists, historians of economics, and many whose research combine these fields. This book honors Patrick Suppes, while at the same time, exhibiting the richness of contemporary philosophy of economics. It was originally published as a special issue of the Journal of Economic Methodology.

Reflection without Rules offers a comprehensive, pointed exploration of the methodological tradition in economics and the breakdown of the received view within the philosophy of science. Professor Hands investigates economists' use of naturalistic and sociological paradigms to model economic phenomena and assesses the roles of pragmatism, discourse, and situatedness in discussions of economic practice before turning to a systematic exploration of more recent developments in economic methodology. The treatment emphasizes the changes taking place in science theory and its relationship to the movement away from a rules-based view of economic methodology. The work will be of interest to all economists concerned with methodological issues as well as philosophers and others studying the relationships between economics and contemporary science theory.

Backing up the pioneering medical researchers and experi menters are the phalanxes and cohorts of practising clinicians in district general hospitals and in general practice who may have to implement and apply any breakthroughs and advances in practical and realistic terms. This they cannot, and should not, be expected to do without careful consideration and analysis. It is essential, therefore, to have regular reviews of the growing points of medicine which are constructively critical as well as being enthusiastic and which can present the issues and implications clearly and fairly to clinicians. The Practical Clinical Medicine series is designed to provide such regular reviews on selected subjects. Each volume is under the charge of an invited editor who selects his team of 4--6 experts. Each contribution is an authoritative, detailed and referenced examination of his topic, is clearly presented in an understandable manner and is practical, relevant and applic able to everyday clinical practice. The series is intended as a means of communication between researchers and practising clinicians. It is dedicated to gener alists who provide primary health care in general practice and to generalists providing secondary medical care in district vii viii Series Editors' Foreword general hospitals. Both are involved in applying good general practical clinical medicine for their patients, but can only succeed in a climate of constant review and examination."

Patrick Suppes (1922-2014) was an extraordinarily wide-ranging scholar. Although best known as a philosopher of science, Suppes made substantial contributions to a remarkably wide range of different fields of research including many relevant to economics: decision theory, philosophy of economics, modeling theory, foundations of measurement, philosophy of psychology (and thus what is now behavioral economics), and many other fields. This collection recognizes Suppes's contributions to economics and economic methodology with a symposium of papers that examine, build on, and/or assess Suppes's research in these areas. The authors include philosophers, economists, game theorists, historians of economics, and many whose research combine these fields. This book honors Patrick Suppes, while at the same time, exhibiting the richness of contemporary philosophy of economics. It was originally published as a special issue of the Journal of Economic Methodology.

This is the first book to describe the entire developmental history of the human aspects of economics. The issue of "self-interest" is discussed throughout, from pre-Adam Smith to contemporary neuroeconomics, representing a unique contribution to economics. Though the notion of self-interest has been interpreted in several ways by various schools of economics and economists since Smith first placed it at the heart of the field, this is the first book to focus on this important but overlooked topic. Traditionally, economic theory has presupposed that the core of human behavior is self-interest. Nevertheless, some economists, e.g. recent behavioral economists, have cast doubt on this "self-interested" explanation. Further, though many economists have agreed on the central role of self-interest in economic behavior, each economist's positioning of self-interest in economic theory differs to some degree. This book helps to elucidate the position of self-interest in economic theory. Given its focus, it is a must-read companion, not only on the history of economic thought but also on economic theory. Furthermore, as today's capitalism is increasingly causing people to wonder just where self-interest lies, it also appeals to general readers.

This volume is a wide-ranging tool for studying protein-carbohydrate interactions that extend from traditional biochemical methods to state-of-the-art techniques. This book focuses on four different research themes: Part I describes methods for screening and quantifying CAZyme activity; Part II contains methods for investigating the interactions between proteins and carbohydrate ligands; Part III discusses methods for the visualization of carbohydrates and protein-carbohydrate complexes; and Part IV focuses on structural and "omic" approaches for studying systems of CAZymes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Protein-Carbohydrate Interactions: Methods and Protocols is a valuable resource to the glycomics research community. In this continuously advancing field, the methods in this book highlight the biology of glycomics, thus driving biotechnological innovation and solutions for human health and sustainable resources within the emerging green community.

This practical resource provides an evidence-based framework for treating clients struggling with perfectionism, whether as the main presenting problem or in conjunction with depression, eating disorders, anxiety disorders, or obsessive-compulsive disorder. Using a case formulation approach, the authors draw on their extensive cognitive-behavioral therapy (CBT) experience to present specific techniques and interventions. Coverage spans treatment planning, the therapeutic alliance, key obstacles that may arise, relapse prevention, and emerging research. Reproducible assessment scales and 36 patient handouts are included; purchasers get access to a Web page where they can download and print the reproducible materials in a convenient 8 1/2 x 11 size.