This book provides in-depth coverage of Pure Mathematics 2 & 3 for Cambridge International AS and A Level Mathematics 9709, for examination from 2020 onwards. With a clear focus on mathematics in life and work, this text builds the key mathematical skills and knowledge that will open up a wide range of careers and further study. Exam Board: Cambridge Assessment International Education First teaching: 2018 First exams: 2020 This student book is part of a series of nine books covering the complete syllabus for Cambridge International AS and A Level Mathematics (9709) and Further Mathematics (9231), for first teaching from September 2018 and examination from 2020. This title is endorsed by Cambridge Assessment International Education. Written by expert authors, this Student Book: * covers all the content of Pure Mathematics 2 and the additional A Level-only content for Pure Mathematics 3 with clear references to what you will learn at the start of each chapter, and coverage that clearly and directly matches the Cambridge syllabus * sets mathematics in real-world contexts that emphasise practical applications and career paths, with inspiring case studies and discussion activities that showcase how mathematics is relevant to different roles * develops the key A Level mathematical skills of mathematical modelling, problem-solving and communication through dedicated questions and teaching * helps you master mathematics with varied practice to develop understanding, exam-style questions to test comprehension, and selected Cambridge past paper questions to help prepare for examination * gives you control of your learning with prior knowledge checks to assess readiness and end-of-chapter summaries that test understanding * supports you through the course with detailed explanations, clear worked examples and plenty of graduated practice on each topic with full workings shown for each answer * provides clear progression from IGCSE (R) Mathematics and develops confident, independent and reflective mathematicians through extension questions and group discussions * supports mathematical communication and literacy with key terms for each topic explained and supported by a comprehensive glossary.

This book provides in-depth coverage of Pure Mathematics 1 for Cambridge International AS and A Level Mathematics 9709, for examination from 2020 onwards. With a clear focus on mathematics in life and work, this text builds the key mathematical skills and knowledge that will open up a wide range of careers and further study. Exam Board: Cambridge Assessment International Education First teaching: 2018 First examination: 2020 This student book is part of a series of nine books covering the complete syllabus for Cambridge International AS and A Level Mathematics (9709) and Further Mathematics (9231), for first teaching from September 2018 first examination from 2020. This title is endorsed by Cambridge Assessment International Education. Written by expert authors, this Student Book: • covers all the content of Pure Mathematics 1 with clear references to what you will learn at the start of each chapter, and coverage that clearly and directly matches the Cambridge syllabus • sets mathematics in real-world contexts that emphasise practical applications and career paths, with inspiring case studies and discussion activities that showcase how mathematics is relevant to different roles • develops the key A Level mathematical skills of mathematical modelling, problem-solving and communication through dedicated questions and teaching • helps you master mathematics with varied practice to develop understanding, exam-style questions to test comprehension, and selected Cambridge past paper questions to help prepare for examination • gives you control of your learning with prior knowledge checks to assess readiness and end-of-chapter summaries that test understanding • supports you through the course with detailed explanations, clear worked examples and plenty of graduated practice on each topic with full workings shown for each answer • provides clear progression from IGCSE® Mathematics and develops confident, independent and reflective mathematicians through extension questions and group discussions • supports mathematical communication and literacy with key terms for each topic explained and supported by a comprehensive glossary.

This book provides in-depth coverage of Further Pure Mathematics 1 for Cambridge International AS and A Level Further Mathematics 9231, for examination from 2020 onwards. With a clear focus on mathematics in life and work, this text builds the key mathematical skills and knowledge that will open up a wide range of careers and further study. Exam Board: Cambridge Assessment International Education First teaching: 2018 First examination: 2020 This student book is part of a series of nine books covering the complete syllabus for Cambridge International AS and A Level Mathematics (9709) and Further Mathematics (9231), for first teaching from September 2018 and first examination from 2020. This title is endorsed by Cambridge Assessment International Education. Written by expert authors, this Student Book: * covers the complete content of Further Pure Mathematics 1 with clear references to what you will learn at the start of each chapter, and coverage that clearly and directly matches the Cambridge syllabus * sets mathematics in real-world contexts that emphasise practical applications and career paths, with inspiring case studies and discussion activities that showcase how mathematics is relevant to different roles * develops the key A Level mathematical skills of mathematical modelling, problem-solving and communication through dedicated questions and teaching * helps you master mathematics with varied practice to develop understanding, exam-style questions to test comprehension, and selected Cambridge past paper questions to help prepare for examination * gives you control of your learning with prior knowledge checks to assess readiness and end-of-chapter summaries that test understanding * supports you through the course with detailed explanations, clear worked examples and plenty of graduated practice on each topic with full workings shown for each answer * provides clear progression from A Level Mathematics and develops confident, independent and reflective mathematicians through extension questions and group discussions * supports mathematical communication and literacy with key terms for each topic explained and supported by a comprehensive glossary.

In order to make further progress in elucidating the mechanism of NOS catalysis it will be essential to throw light on the interaction between the enzyme and its substrate. An understanding of the catalytic site will also assist the development of therapeutically important NOS inhibitors. In particular. it will be useful to uncover any differences that exist between the substrate binding sites of the three NOS isozymes which might be exploited for the development of isoform selective NOS inhibitors. A comparison of NOS to other Arg-binding proteins has shown no significant sequence homology (159). Moreover, the lack of a 3D structure and absence of significant sequence homology between the NOS oxygenase domain and known cytochromes P450 has made it difficult to identify residues and construct a model of the distal heme pocket responsible for substrate binding. However, a number of groups are currently working towards crystallisation of the separate NOS reductase and oxygenase domains of the three isoforms for X-ray diffraction studies; the first X-ray structure is likely to be forthcoming within a matter of months. * The results of these studies are expected to resolve many of the uncertainties surrounding the structure of the NOS catalytic site. Preliminary X-ray diffraction analysis of CPR from rat liver has already been reported by MASTERS et al. (524) and the future emergence of a detailed structure for this protein should throw light on the structure and function of the NOS reductase domain.

In order to make further progress in elucidating the mechanism of NOS catalysis it will be essential to throw light on the interaction between the enzyme and its substrate. An understanding of the catalytic site will also assist the development of therapeutically important NOS inhibitors. In particular. it will be useful to uncover any differences that exist between the substrate binding sites of the three NOS isozymes which might be exploited for the development of isoform selective NOS inhibitors. A comparison of NOS to other Arg-binding proteins has shown no significant sequence homology (159). Moreover, the lack of a 3D structure and absence of significant sequence homology between the NOS oxygenase domain and known cytochromes P450 has made it difficult to identify residues and construct a model of the distal heme pocket responsible for substrate binding. However, a number of groups are currently working towards crystallisation of the separate NOS reductase and oxygenase domains of the three isoforms for X-ray diffraction studies; the first X-ray structure is likely to be forthcoming within a matter of months. * The results of these studies are expected to resolve many of the uncertainties surrounding the structure of the NOS catalytic site. Preliminary X-ray diffraction analysis of CPR from rat liver has already been reported by MASTERS et al. (524) and the future emergence of a detailed structure for this protein should throw light on the structure and function of the NOS reductase domain.

Although one in ten women in the UK suffer from polycistic ovary syndrome (PCOS), with a myriad of symptoms and the problem that many doctors do not recognise this condition – sufferers often experience an uphill battle for diagnosis and help.This is the first book to tackle the issue of PCOS. Written by a sufferer, this book offers essential advice on dealing with this gynaecological disorder which can effect everything from weight to infertility and therefore impacts on a woman’s sense of self.The book will look at how PCOS effects the body, but above all it will offer an essential self help plan for dealing with the condition. PCOS will include a 4-point wellness plan, an A-Z of symptoms and associated remedies and a section on self esteem and rebuilding your life.As well as the common symptoms of weight gain, excess body hair, acne, breast pain, dizziness, chronic fatigue and hair loss, sufferers from PCOS can experience associated health risks including a higher risk of miscarriage, heart disease, diabetes but infertility is still their largest worry.Colette Harris has put together a valuable self help regime – which looks at both conventional and complementary medicine. The 4 step plan will focus on diet, exercise, supplementation and relaxation.

In recent decades, the sporting landscape has seen many changes, notably the inclusion and professionalization of sport science and coaching. With this change has come significant demand for applied research surrounding football science and performance coaching, leading to new theory and methodology across all aspects of the game. This book brings together the most fundamental components of football science and performance coaching through modern, integrated coaching science methods implemented by leading practitioners and researchers. The expertise included in this book provides a unique blend of modern, football-specific research trends with innovative coaching theory, implemented at an elite level, and will ultimately enhance the knowledge of coaches and medical and performance specialists, all while advocating an applied alternative to the development of players. The book is divided into three main sections: prepare, perform, recover. With each section, leaders in the fields of applied sport science, sport and exercise science, sport psychology, sport nutrition, and strength and conditioning outline the best coaching and training methods, making this book a must-have for coaches and trainers seeking to augment their own understanding of what is required to enhance player development.

This book provides in-depth coverage of Probability & Statistics 1 for Cambridge International AS and A Level Mathematics 9709, for examination from 2020 onwards. With a clear focus on mathematics in life and work, this text builds the key mathematical skills and knowledge that will open up a wide range of careers and further study. Exam Board: Cambridge Assessment International Education First teaching: 2018 First examination: 2020 This student book is part of a series of nine books covering the complete syllabus for Cambridge International AS and A Level Mathematics (9709) and Further Mathematics (9231), for first teaching from September 2018 and examination from 2020. This title is endorsed by Cambridge Assessment International Education. Written by expert authors, this Student Book: * covers the complete content of Probability & Statistics 1 with clear references to what you will learn at the start of each chapter, and coverage that clearly and directly matches the Cambridge syllabus * sets mathematics in real-world contexts that emphasise practical applications and career paths, with inspiring case studies and discussion activities that showcase how mathematics is relevant to different roles * develops the key A Level mathematical skills of mathematical modelling, problem-solving and communication through dedicated questions and teaching * helps you master mathematics with varied practice to develop understanding, exam-style questions to test comprehension, and selected Cambridge past paper questions to help prepare for examination * gives you control of your learning with prior knowledge checks to assess readiness and end-of-chapter summaries that test understanding * supports you through the course with detailed explanations, clear worked examples and plenty of graduated practice on each topic with full workings shown for each answer * provides clear progression from IGCSE (R) Mathematics and develops confident, independent and reflective mathematicians through extension questions and group discussions * supports mathematical communication and literacy with key terms for each topic explained and supported by a comprehensive glossary.

This book provides in-depth coverage of Further Mechanics for Cambridge International AS and A Level Further Mathematics 9231, for examination from 2020 onwards. With a clear focus on mathematics in life and work, this text builds the key mathematical skills and knowledge that will open up a wide range of careers and further study. Exam Board: Cambridge Assessment International Education First teaching: 2018 First examination: 2020 This student book is part of a series of nine books covering the complete syllabus for Cambridge International AS and A Level Mathematics (9709) and Further Mathematics (9231), for first teaching from September 2018 and first examination from 2020. This title is endorsed by Cambridge Assessment International Education. Written by expert authors, this Student Book: * covers the complete content of Further Mechanics with clear references to what you will learn at the start of each chapter, and coverage that clearly and directly matches the Cambridge syllabus * sets mathematics in real-world contexts that emphasise practical applications and career paths, with inspiring case studies and discussion activities that showcase how mathematics is relevant to different roles * develops the key A Level mathematical skills of mathematical modelling, problem-solving and communication through dedicated questions and teaching * helps you master mathematics with varied practice to develop understanding, exam-style questions to test comprehension, and selected Cambridge past paper questions to help prepare for examination * gives you control of your learning with prior knowledge checks to assess readiness and end-of-chapter summaries that test understanding * supports you through the course with detailed explanations, clear worked examples and plenty of graduated practice on each topic with full workings shown for each answer * provides clear progression from A Level Mathematics and develops confident, independent and reflective mathematicians through extension questions and group discussions * supports mathematical communication and literacy with key terms for each topic explained and supported by a comprehensive glossary.

This book provides in-depth coverage of Further Pure Mathematics 2 for Cambridge International A Level Further Mathematics 9231, for examination from 2020 onwards. With a clear focus on mathematics in life and work, this text builds the key mathematical skills and knowledge that will open up a wide range of careers and further study. Exam Board: Cambridge Assessment International Education First teaching: 2018 First examination: 2020 This student book is part of a series of nine books covering the complete syllabus for Cambridge International AS and A Level Mathematics (9709) and Further Mathematics (9231), for first teaching from September 2018 and first examination from 2020. This title is endorsed by Cambridge Assessment International Education. Written by expert authors, this Student Book: * covers the complete content of Further Pure Mathematics 2 with clear references to what you will learn at the start of each chapter, and coverage that clearly and directly matches the Cambridge syllabus * sets mathematics in real-world contexts that emphasise practical applications and career paths, with inspiring case studies and discussion activities that showcase how mathematics is relevant to different roles * develops the key A Level mathematical skills of mathematical modelling, problem-solving and communication through dedicated questions and teaching * helps you master mathematics with varied practice to develop understanding, exam-style questions to test comprehension, and selected Cambridge past paper questions to help prepare for examination * gives you control of your learning with prior knowledge checks to assess readiness and end-of-chapter summaries that test understanding * supports you through the course with detailed explanations, clear worked examples and plenty of graduated practice on each topic with full workings shown for each answer * provides clear progression from A Level Mathematics and develops confident, independent and reflective mathematicians through extension questions and group discussions * supports mathematical communication and literacy with key terms for each topic explained and supported by a comprehensive glossary.

This book provides in-depth coverage of Probability & Statistics 2 for Cambridge International A Level Mathematics 9709, for examination from 2020 onwards. With a clear focus on mathematics in life and work, this text builds the key mathematical skills and knowledge that will open up a wide range of careers and further study. Exam Board: Cambridge Assessment International Education First teaching: 2018 First examination: 2020 This student book is part of a series of nine books covering the complete syllabus for Cambridge International AS and A Level Mathematics (9709) and Further Mathematics (9231), for first teaching from September 2018 and examination from 2020. This title is endorsed by Cambridge Assessment International Education. Written by expert authors, this Student Book: * covers the complete content of Probability & Statistics 2 with clear references to what you will learn at the start of each chapter, and coverage that clearly and directly matches the Cambridge syllabus * sets mathematics in real-world contexts that emphasise practical applications and career paths, with inspiring case studies and discussion activities that showcase how mathematics is relevant to different roles * develops the key A Level mathematical skills of mathematical modelling, problem-solving and communication through dedicated questions and teaching * helps you master mathematics with varied practice to develop understanding, exam-style questions to test comprehension, and selected Cambridge past paper questions to help prepare for examination * gives you control of your learning with prior knowledge checks to assess readiness and end-of-chapter summaries that test understanding * supports you through the course with detailed explanations, clear worked examples and plenty of graduated practice on each topic with full workings shown for each answer * provides clear progression from IGCSE (R) Mathematics and develops confident, independent and reflective mathematicians through extension questions and group discussions * supports mathematical communication and literacy with key terms for each topic explained and supported by a comprehensive glossary.

Given the realities of climate change and sea level rise, coastal cities around the world are struggling with questions of resilience. Resilience, at its core, is about desirable states of the urban social-ecological system and understanding how to sustain those states in an uncertain and tumultuous future. How do physical conditions ecological processes, social objectives, human politics, and history shape the prospects for resilience? Most books set out "the answer." This book sets out a process of grappling with holistic resilience from multiple perspectives, drawing on the insights and experiences of more than fifty Scholars and practitioners working together to make Jamaica Bay in New York-City an example for the world. Prospects for Resilience establishes a framework for understanding resilience practice in urban watersheds. Using Jamaica Bay, the largest contiguous natural area in New York, home to millions of New Yorkers, and a hub of global air travel with John F.Kennedy International Airport, the authors demonstrate how various components of social ecological systems interact, ranging from climatic factors to plant populations to human demographics. They also highlight essential tools for creating resilient Watersheds, including monitoring and identifying system indicators; computer modelling; green infrastructure; and decision science methods. Finally, they look at the role and importance of a "boundary organisation" like the new Science and Resilience Institute at Jamaica Bay in coordinating and facilitating resilience work, and consider significant research questions and prospects for the future-of urban watersheds. Prospects for Resilience sets forth an essential foundation of information and advice for researchers, urban planners, students and others who need to create more resilient cities that work with, not against, nature.

Happiness in 2 steps? That sounds too good to be true. Surely, it must be more complicated than that. Well, I have spent over a decade researching what makes people happier and have distilled it down to 2 steps. 2Steps2Happiness strives to help you: 1) Accomplish your life goals more quickly 2) Experience personal growth and development 3) Define and go after your personal dreams, visions, and passions 4) Discover more effective ways to build healthy relationships 5) Get more out of life 6) Discover a more meaningful and productive life 7) Identify and overcome obstacles to your personal success See my website for more information: http: //2steps2happiness.com

This book provides in-depth coverage of Further Probability & Statistics for Cambridge International AS and A Level Further Mathematics 9231, for examination from 2020 onwards. With a clear focus on mathematics in life and work, this text builds the key mathematical skills and knowledge that will open up a wide range of careers and further study. Exam Board: Cambridge Assessment International Education First teaching: 2018 First examination: 2020 This student book is part of a series of nine books covering the complete syllabus for Cambridge International AS and A Level Mathematics (9709) and Further Mathematics (9231), for first teaching from September 2018 and first examination from 2020. This title is endorsed by Cambridge Assessment International Education. Written by expert authors, this Student Book: * covers the complete content of Further Probability & Statistics with clear references to what you will learn at the start of each chapter, and coverage that clearly and directly matches the Cambridge syllabus * sets mathematics in real-world contexts that emphasise practical applications and career paths, with inspiring case studies and discussion activities that showcase how mathematics is relevant to different roles * develops the key A Level mathematical skills of mathematical modelling, problem-solving and communication through dedicated questions and teaching * helps you master mathematics with varied practice to develop understanding, exam-style questions to test comprehension, and selected Cambridge past paper questions to help prepare for examination * gives you control of your learning with prior knowledge checks to assess readiness and end-of-chapter summaries that test understanding * supports you through the course with detailed explanations, clear worked examples and plenty of graduated practice on each topic with full workings shown for each answer * provides clear progression from A Level Mathematics and develops confident, independent and reflective mathematicians through extension questions and group discussions * supports mathematical communication and literacy with key terms for each topic explained and supported by a comprehensive glossary.

This book provides in-depth coverage of Mechanics for Cambridge International AS and A Level Mathematics 9709, for examination from 2020 onwards. With a clear focus on mathematics in life and work, this text builds the key mathematical skills and knowledge that will open up a wide range of careers and further study.

Exam Board: Cambridge Assessment International Education
First teaching: 2018 First examination: 2020

This student book is part of a series of nine books covering the complete syllabus for Cambridge International AS and A Level Mathematics (9709) and Further Mathematics (9231), for first teaching from September 2018 and first examination from 2020. This title is endorsed by Cambridge Assessment International Education.

Written by expert authors, this Student Book:

• covers the complete content of Mechanics (formerly Mechanics 1) with clear references to what you will learn at the start of each chapter, and coverage that clearly and directly matches the Cambridge syllabus
• sets mathematics in real-world contexts that emphasise practical applications and career paths, with inspiring case studies and discussion activities that showcase how mathematics is relevant to different roles
• develops the key A Level mathematical skills of mathematical modelling, problem-solving and communication through dedicated questions and teaching
• helps you master mathematics with varied practice to develop understanding, exam-style questions to test comprehension, and selected Cambridge past paper questions to help prepare for examination
• gives you control of your learning with prior knowledge checks to assess readiness and end-of-chapter summaries that test understanding
• supports you through the course with detailed explanations, clear worked examples and plenty of graduated practice on each topic with full workings shown for each answer
• provides clear progression from IGCSE® Mathematics and develops confident, independent and reflective mathematicians through extension questions and group discussions
• supports mathematical communication and literacy with key terms for each topic explained and supported by a comprehensive glossary.