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Biophysical Characterization of Proteins in Developing Biopharmaceuticals (Hardcover): Damian J. Houde, Steven A. Berkowitz Biophysical Characterization of Proteins in Developing Biopharmaceuticals (Hardcover)
Damian J. Houde, Steven A. Berkowitz
R4,234 Discovery Miles 42 340 Ships in 12 - 19 working days

"Biophysical Characterization of Proteins in Developing Biopharmaceuticals" is concerned with the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure this book takes the reader on a journey on how to best achieve this goal using the key relevant and practical methods commonly employed in the biopharmaceutical industry today as well as up and coming promising methods that are now gaining increasing attention.

As a general resource guide this book has been written with the intent to help today s industrial scientists working in the biopharmaceutical industry or the scientists of tomorrow who are planning a career in this industry on how to successfully implement these biophysical methodologies. In so doing a keen focus is placed on understanding the capability of these methodologies in terms of what information they can deliver. Aspects of how to best acquire this biophysical information on these very complex drug molecules, while avoiding potential pitfalls, in order to make concise, well informed productive decisions about their development are key points that are also covered.
Presents the reader with a clear understanding of the real world issues and challenges in using these methods.Highlights the capabilities and limitations of each method.Discusses how to best analyze the data generated from these methods.Points out what one needs to look for to avoid making faulty conclusions and mistakes.In total it provides a check list or road map that empowers the industrial scientists as to what they need to be concerned with in order to effectively do their part in successfully developing these new drugs in an efficient and cost effective manner."

Biophysical Characterization of Proteins in Developing Biopharmaceuticals (Paperback, 2nd edition): Damian J. Houde, Steven A.... Biophysical Characterization of Proteins in Developing Biopharmaceuticals (Paperback, 2nd edition)
Damian J. Houde, Steven A. Berkowitz
R5,255 Discovery Miles 52 550 Ships in 12 - 19 working days

Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today's industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been fully revised, with new chapters focusing on the use of chromatography and electrophoresis and the biophysical characterization of very large biopharmaceuticals. In addition, best practices of applying statistical analysis to biophysical characterization data is included, along with practical issues associated with the concept of a biopharmaceutical's developability and the technical decision-making process needed when dealing with biophysical characterization data.

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