This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students.

Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book.

Part II is the core of the book, in which we focus on the analysis of dose-response microarray data. Methodological topics discussed include:

Multiplicity adjustment

Test statistics and procedures for the analysis of dose-response microarray data

Resampling-based inference and use of the SAM method for small-variance genes in the data

Identification and classification of dose-response curve shapes

Clustering of order-restricted (but not necessarily monotone) dose-response profiles

Gene set analysis to facilitate the interpretation of microarray results

Hierarchical Bayesian models and Bayesian variable selection

Non-linear models for dose-response microarray data

Multiple contrast tests

Multiple confidence intervals for selected parameters adjusted for the false coverage-statement rate

All methodological issues in the book are illustrated using real-world examples of dose-response microarray datasets from early drug development experiments.

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Mere decades ago, the population of Guangzhou was almost wholly Chinese. Today, it is a truly global city, a place where people from around the world go to make new lives, find themselves, or further their careers. A large number of those migrants are small-scale traders from Africa who deal in Chinese goods often knock-offs or copies of high-end branded items to send back to their home countries. In The World in Guangzhou, Gordon Mathews explores the question of how the city became such a center of "low-end" globalization and shows what we can learn from that experience similar transformations elsewhere in the world. Through detailed ethnographic portraits, Mathews reveals a world of globalization based on informality, reputation, and trust rather than on formal contracts. How, he asks, can such informal relationships emerge between two groups Chinese and Sub-Saharan Africans that don't share a common language, culture, or religion? And what happens when Africans move beyond their status as temporary residents and begin to put down roots and establish families? Full of unforgettable characters, The World in Guangzhou presents a compelling account of globalization at ground level and offers a look into the future of urban life as transnational connections continue to remake cities around the world.

Mere decades ago, the population of Guangzhou was almost wholly Chinese. Today, it is a truly global city, a place where people from around the world go to make new lives, find themselves, or further their careers. A large number of those migrants are small-scale traders from Africa who deal in Chinese goods often knock-offs or copies of high-end branded items to send back to their home countries. In The World in Guangzhou, Gordon Mathews explores the question of how the city became such a center of "low-end" globalization and shows what we can learn from that experience similar transformations elsewhere in the world. Through detailed ethnographic portraits, Mathews reveals a world of globalization based on informality, reputation, and trust rather than on formal contracts. How, he asks, can such informal relationships emerge between two groups Chinese and Sub-Saharan Africans that don't share a common language, culture, or religion? And what happens when Africans move beyond their status as temporary residents and begin to put down roots and establish families? Full of unforgettable characters, The World in Guangzhou presents a compelling account of globalization at ground level and offers a look into the future of urban life as transnational connections continue to remake cities around the world.