The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development.

The ideas of Fourier have made their way into every branch of mathematics and mathematical physics, from the theory of numbers to quantum mechanics. Fourier Series and Integrals focuses on the extraordinary power and flexibility of Fourier's basic series and integrals and on the astonishing variety of applications in which it is the chief tool. It presents a mathematical account of Fourier ideas on the circle and the line, on finite commutative groups, and on a few important noncommutative groups. A wide variety of exercises are placed in nearly every section as an integral part of the text.

Most probability problems involve random variables indexed by space and/or time. These problems almost always have  a version in which space and/or time are taken to be discrete. This volume deals with areas in which the discrete version is more natural than the continuous one, perhaps even the only one than can be formulated without complicated constructions and machinery. The 5 papers of this volume discuss problems in which there has been significant progress in the last few years; they are motivated by, or have been developed in parallel with, statistical physics. They include questions about asymptotic shape for stochastic growth models and for random clusters; existence, location and properties of phase transitions; speed of convergence to equilibrium in Markov chains, and in particular for Markov chains based on models with a phase transition; cut-off phenomena for random walks. The articles can be read independently of each other. Their unifying theme is that of models built on discrete spaces or graphs. Such models are often easy to formulate. Correspondingly, the book requires comparatively little previous knowledge of the machinery of probability.

Many leisure activities involve the use of turf as a surface. Grass surfaces on golf courses, bowling clubs, cricket pitches, racetracks, and parks all require maintenance by trained personnel. International Turf Management Handbook is written by a team of international experts. It covers all aspects of turf management and in particular * the selection and establishment of grass varieties * soils, irrigation and drainage * performance testing and playing qualities * issues relating to specific playing surfaces In its depth of coverage and detailed practical advice from around the world this comprehensive handbook is destined to become the standard reference work on the subject.

The articles in this volume present the state of the art in a variety of areas of discrete probability, including random walks on finite and infinite graphs, random trees, renewal sequences, Stein's method for normal approximation and Kohonen-type self-organizing maps. This volume also focuses on discrete probability and its connections with the theory of algorithms. Classical topics in discrete mathematics are represented as are expositions that condense and make readable some recent work on Markov chains, potential theory and the second moment method. This volume is suitable for mathematicians and students.

This innovative and user-friendly book uses a design thinking approach to examine transformative learning and liminality in physical education. Covering theory and practice, it introduces the important idea of 'threshold concepts' for physical education, helping physical educators to introduce those concepts into curriculum, pedagogy and assessment. The book invites us to reflect on what is learned in, through and about physical education - to identify its core threshold concepts. Once identified, the book explains how the learning of threshold concepts can be planned using principles of pedagogical translation for all four learning domains (cognitive, psychomotor, affective and social). The book is arranged into three key sections which walk the reader through the underpinning concepts, use movement case studies to explore and generate threshold concepts in physical education using design thinking approach and, finally, provide a guiding Praxis Matrix for PE Threshold Concepts that can be used for physical educators across a range of school and physical activity learning contexts. Outlining fundamental theory and useful, practical teaching and coaching advice, this book is invaluable reading for all PE teacher educators, coach educators, and any advanced student, coach or teacher looking to enrich their knowledge and professional practice.

This innovative and user-friendly book uses a design thinking approach to examine transformative learning and liminality in physical education. Covering theory and practice, it introduces the important idea of 'threshold concepts' for physical education, helping physical educators to introduce those concepts into curriculum, pedagogy and assessment. The book invites us to reflect on what is learned in, through and about physical education - to identify its core threshold concepts. Once identified, the book explains how the learning of threshold concepts can be planned using principles of pedagogical translation for all four learning domains (cognitive, psychomotor, affective and social). The book is arranged into three key sections which walk the reader through the underpinning concepts, use movement case studies to explore and generate threshold concepts in physical education using design thinking approach and, finally, provide a guiding Praxis Matrix for PE Threshold Concepts that can be used for physical educators across a range of school and physical activity learning contexts. Outlining fundamental theory and useful, practical teaching and coaching advice, this book is invaluable reading for all PE teacher educators, coach educators, and any advanced student, coach or teacher looking to enrich their knowledge and professional practice.

If you place a large number of points randomly in the unit square, what is the distribution of the radius of the largest circle containing no points? Of the smallest circle containing 4 points? Why do Brownian sample paths have local maxima but not points of increase, and how nearly do they have points of increase? Given two long strings of letters drawn i. i. d. from a finite alphabet, how long is the longest consecutive (resp. non-consecutive) substring appearing in both strings? If an imaginary particle performs a simple random walk on the vertices of a high-dimensional cube, how long does it take to visit every vertex? If a particle moves under the influence of a potential field and random perturbations of velocity, how long does it take to escape from a deep potential well? If cars on a freeway move with constant speed (random from car to car), what is the longest stretch of empty road you will see during a long journey? If you take a large i. i. d. sample from a 2-dimensional rotationally-invariant distribution, what is the maximum over all half-spaces of the deviation between the empirical and true distributions? These questions cover a wide cross-section of theoretical and applied probability. The common theme is that they all deal with maxima or min ima, in some sense."

Discrete probability theory and the theory of algorithms have become close partners over the last ten years, though the roots of this partnership go back much longer. The papers in this volume address the latest developments in this active field. They are from the IMA Workshops "Probability and Algorithms" and "The Finite Markov Chain Renaissance." They represent the current thinking of many of the world's leading experts in the field.

Researchers and graduate students in probability, computer science, combinatorics, and optimization theory will all be interested in this collection of articles. The techniques developed and surveyed in this volume are still undergoing rapid development, and many of the articles of the collection offer an expositionally pleasant entree into a research area of growing importance.

The articles in this volume present the state of the art in a variety of areas of discrete probability, including random walks on finite and infinite graphs, random trees, renewal sequences, Stein's method for normal approximation and Kohonen-type self-organizing maps. This volume also focuses on discrete probability and its connections with the theory of algorithms. Classical topics in discrete mathematics are represented as are expositions that condense and make readable some recent work on Markov chains, potential theory and the second moment method. This volume is suitable for mathematicians and students.

Discrete probability theory and the theory of algorithms have become close partners over the last ten years, though the roots of this partnership go back much longer. The papers in this volume address the latest developments in this active field. They are from the IMA Workshops "Probability and Algorithms" and "The Finite Markov Chain Renaissance." They represent the current thinking of many of the world's leading experts in the field. Researchers and graduate students in probability, computer science, combinatorics, and optimization theory will all be interested in this collection of articles. The techniques developed and surveyed in this volume are still undergoing rapid development, and many of the articles of the collection offer an expositionally pleasant entree into a research area of growing importance.

If you place a large number of points randomly in the unit square, what is the distribution of the radius of the largest circle containing no points? Of the smallest circle containing 4 points? Why do Brownian sample paths have local maxima but not points of increase, and how nearly do they have points of increase? Given two long strings of letters drawn i. i. d. from a finite alphabet, how long is the longest consecutive (resp. non-consecutive) substring appearing in both strings? If an imaginary particle performs a simple random walk on the vertices of a high-dimensional cube, how long does it take to visit every vertex? If a particle moves under the influence of a potential field and random perturbations of velocity, how long does it take to escape from a deep potential well? If cars on a freeway move with constant speed (random from car to car), what is the longest stretch of empty road you will see during a long journey? If you take a large i. i. d. sample from a 2-dimensional rotationally-invariant distribution, what is the maximum over all half-spaces of the deviation between the empirical and true distributions? These questions cover a wide cross-section of theoretical and applied probability. The common theme is that they all deal with maxima or min ima, in some sense."

Most probability problems involve random variables indexed by space and/or time. These problems almost always have a version in which space and/or time are taken to be discrete. This volume deals with areas in which the discrete version is more natural than the continuous one, perhaps even the only one than can be formulated without complicated constructions and machinery. The 5 papers of this volume discuss problems in which there has been significant progress in the last few years; they are motivated by, or have been developed in parallel with, statistical physics. They include questions about asymptotic shape for stochastic growth models and for random clusters; existence, location and properties of phase transitions; speed of convergence to equilibrium in Markov chains, and in particular for Markov chains based on models with a phase transition; cut-off phenomena for random walks. The articles can be read independently of each other. Their unifying theme is that of models built on discrete spaces or graphs. Such models are often easy to formulate. Correspondingly, the book requires comparatively little previous knowledge of the machinery of probability.

Linear models, normally presented in a highly theoretical and mathematical style, are brought down to earth in this comprehensive textbook. Linear Models examines the subject from a mean model perspective, defining simple and easy-to-learn rules for building mean models, regression models, mean vectors, covariance matrices and sums of squares matrices for balanced and unbalanced data sets. The author includes both applied and theoretical discussions of the multivariate normal distribution, quadratic forms, maximum likelihood estimation, less than full rank models, and general mixed models. The mean model is used to bring all of these topics together in a coherent presentation of linear model theory.
Key Features
* Provides a versatile format for investigating linear model theory, using the mean model
* Uses examples that are familiar to the student:
* design of experiments, analysis of variance, regression, and normal distribution theory
* Includes a review of relevant linear algebra concepts
* Contains fully worked examples which follow the theorem/proof presentation