This is the first monograph on computation in living cells - one of the central and fastest growing areas of research in this field. Gene assembly in ciliates (unicellular organisms) is a splendid example of such computations. This work has helped to clarify important biological aspects of gene assembly, yielded novel insights into the nature of computation, and broadened our understanding of what computation is about. The monograph gives an accessible account of both the biology and the formal analysis of the gene assembly process. It can be used as a textbook for either graduate courses or seminars.

Advances in Cell Biology has been initiated as a continuing, multi-volume series to report on the progress of a wide spectrum of problems of cell structure and cell function. Jn arranging these volumes individual contributors are asked not only to review the major new information, but especially to present the state of a given problem or area by discussing the current central issues, speculations, concepts, hypotheses, and technical problems. We intend, in addition, that these volumes will not be concerned with comprehensive reviews of the recent literature but will consist rather of presentations of an interpretive and integrative nature, based on selection of major research advances. It is our aim that these volumes should provide the means whereby cell biologists may keep themselves reasonably well informed about the current progress in research areas in cell biology in which they are not immediately or directly involved themselves. The articles, nevertheless, are expected to bring into focus the experimental objectives of the specialists in a given research area. D. M.P. L. G. E.M. vii Contents Contributors v Preface vii 1 1. The Regulation of DNA Synthesis in Eukaryotes James Douglas Watson 2. D.RNA Containing Ribonucleoprotein Particles and Messenger RNA Transport 47 G. P. Georgiev and 0. P. Samarina Recent Developments in the Synchronization of 3. Tetrahymena Cell Cycle 111 Eric Zeuthen 153 4. Repetitious DNA Christopher Bostock 5. Mitosis 225 R. Bruce Nicklas Specific Enzyme Production in Eukaryotic Cells 299 6."

Advances in Cell Biology has been initiated as a continuing, multi-volume series to report on the progress of a wide spectrum of problems of cell structure and cell func tion. In arranging these volumes individual contributors are asked not only to review the major new information, but especially to present the state of a given problem or area by discussing the current central issues, speculations, concepts, hypotheses, and technical problems. We intend, in addition, that these volumes will not be concerned with comprehensive reviews of the recent literature but will consist rather of presenta tions of an interpretative and integrative nature, based on selection of major research advances. It is our aim that these volumes should provide the means whereby cell biologists may keep themselves reasonably well informed about the current progress in research areas in cell biology in which they are not immediately or directly involved themselves. The articles, nevertheless, are expected to bring into focus the experimental objectives of the specialists in a given research area. D.M.P. L. G. E. M. vii Contents v Contributors Preface vii Bacterial Chromosome Replication 3 I. Peter L. Kuempel 57 2. Structure and Replication of Eukaryotic Chromosomes David M. Prescott Ultrastructure and Interaction of the Kinetochore and Centriole 3.

This is the first monograph on computation in living cells - one of the central and fastest growing areas of research in this field. Gene assembly in ciliates (unicellular organisms) is a splendid example of such computations. This work has helped to clarify important biological aspects of gene assembly, yielded novel insights into the nature of computation, and broadened our understanding of what computation is about. The monograph gives an accessible account of both the biology and the formal analysis of the gene assembly process. It can be used as a textbook for either graduate courses or seminars.