By now everyone acknowledges that organizations and institutions have been profoundly affected by COVID-19 and will not be returning to normal. Therefore, they have started looking ahead to the new normal that is now being created. What are the practices, policies, technologies, and interactions that will define this new normal? What is the future of leadership, culture, and technology in a Post COVID world? This publication delves into how virtual technology has evolved to create remote office and remote teaming in health, education, engineering, and other business solutions. The chapters explore culture in business and how individuals may interface, communicate, and collaborate in past, current, and future business models. Technology and leadership have an impact on how the interface occurs and culture as a whole. Leadership is the number one driver of culture through agenda, work models, vision, purpose, and inspiration. The new models of business will force a change in how Leadership continues to impact culture and continuation of the business.