This proceedings volume convenes selected, peer-reviewed contributions presented at the POMS 2021 - International Conference on Production and Operations Management, which was virtually held in Lima, Peru, December 2-4, 2021. This book presents results in the field of Operations Management of key relevance to practitioners, instructors, and students. Topics focus on Operations Management, Logistics and Supply Chain Management, and Industrial and Production Engineering and Management, where mathematics and its applications play a role. In this work, readers will find a colorful collection of real-world case studies, accompanied by operations research-based managerial models. They touch on myriad topics, ranging from Artificial Intelligence and Data Analytics in Operations, Defense, Tourism, and other emerging issues in Operations Management to Healthcare Operations Management and Humanitarian Operations and Crisis Management. The POMS Lima 2021 International Conference has been organized by the Latin America & Caribbean Chapter of the Production and Operations Management Society, the most renowned professional and academic organization representing the interests of production and operations management professionals and academicians around the world. Since 2018, POMS International Conferences have been organized by POMS-LA, the first venue being in Rio de Janeiro, Brazil. Venue 2021 event was hosted by the Pontifical Catholic University of Peru and Pacific University, two Peruvian Latin-American leading academic institutions from Peru.