Now completely updated! The best-selling, most comprehensive guide to lupus, its complications, and management. Lupus is an autoimmune disease that can attack any body organ. It is three times more common in the United States today than it was in the 1980s, so there is an increased need for accurate, practical information on this potentially devastating disease. Lupus expert and clinician Donald E. Thomas, Jr., MD, provides all the helpful information patients need so they can understand and treat this disease. Highlighting amazing advancements in the diagnosis and treatment of lupus, this edition includes new and expanded information on: • The latest FDA-approved medications • How lupus affects different body parts • Advanced labs that improve lupus diagnosis and treatment • The role of the microbiome and anti-inflammatory diets • Updated recommendations for those who are pregnant or breastfeeding • Childhood-onset lupus • The interaction between COVID-19 and lupus • Non-drug treatments, complementary medicine, and medical cannabis The gold standard since it was first published and carefully reviewed by experts in the field, the latest edition of The Lupus Encyclopedia is essential for patients, health care providers, and families. Bonus content on insurance issues and information about working with lupus and disability is also available online. Endorsed by The Lupus Foundation of America Contributors: Jemima Albayda, MD; Divya Angra, MD; Alan N. Baer, MD; Sasha Bernatsky, MD, PhD; George Bertsias, MD, PhD; Ashira D. Blazer, MD; Ian Bruce, MD; Jill Buyon, MD; Yashaar Chaichian, MD; Maria Chou, MD; Sharon Christie, Esq; Angelique N. Collamer, MD; Ashté Collins, MD; Caitlin O. Cruz, MD; Mark M. Cruz, MD; Dana DiRenzo, MD; Jess D. Edison, MD; Titilola Falasinnu, PhD; Andrea Fava, MD; Cheri Frey, MD; Neda F. Gould, PhD; Nishant Gupta, MD; Sarthak Gupta, MD; Sarfaraz Hasni, MD; David Hunt, MD; Mariana J. Kaplan, MD; Alfred Kim, MD; Deborah Lyu Kim, DO; Rukmini Konatalapalli, MD; Fotios Koumpouras, MD; Vasileios C. Kyttaris, MD; Jerik Leung, MPH; Hector A. Medina, MD; Timothy Niewold, MD; Julie Nusbaum, MD; Ginette Okoye, MD; Sarah L. Patterson, MD; Ziv Paz, MD; Darryn Potosky, MD; Rachel C. Robbins, MD; Neha S. Shah, MD; Matthew A. Sherman, MD; Yevgeniy Sheyn, MD; Julia F. Simard, ScD; Jonathan Solomon, MD; Rodger Stitt, MD; George Stojan, MD; Sangeeta Sule, MD; Barbara Taylor, CPPM, CRHC; George Tsokos, MD; Ian Ward, MD; Emma Weeding, MD; Arthur Weinstein, MD; Sean A. Whelton, MD

Now completely updated! The best-selling, most comprehensive guide to lupus, its complications, and management. Lupus is an autoimmune disease that can attack any body organ. It is three times more common in the United States today than it was in the 1980s, so there is an increased need for accurate, practical information on this potentially devastating disease. Lupus expert and clinician Donald E. Thomas, Jr., MD, provides all the helpful information patients need so they can understand and treat this disease. Highlighting amazing advancements in the diagnosis and treatment of lupus, this edition includes new and expanded information on: • The latest FDA-approved medications • How lupus affects different body parts • Advanced labs that improve lupus diagnosis and treatment • The role of the microbiome and anti-inflammatory diets • Updated recommendations for those who are pregnant or breastfeeding • Childhood-onset lupus • The interaction between COVID-19 and lupus • Non-drug treatments, complementary medicine, and medical cannabis The gold standard since it was first published and carefully reviewed by experts in the field, the latest edition of The Lupus Encyclopedia is essential for patients, health care providers, and families. Bonus content on insurance issues and information about working with lupus and disability is also available online. Endorsed by The Lupus Foundation of America Contributors: Jemima Albayda, MD; Divya Angra, MD; Alan N. Baer, MD; Sasha Bernatsky, MD, PhD; George Bertsias, MD, PhD; Ashira D. Blazer, MD; Ian Bruce, MD; Jill Buyon, MD; Yashaar Chaichian, MD; Maria Chou, MD; Sharon Christie, Esq; Angelique N. Collamer, MD; Ashté Collins, MD; Caitlin O. Cruz, MD; Mark M. Cruz, MD; Dana DiRenzo, MD; Jess D. Edison, MD; Titilola Falasinnu, PhD; Andrea Fava, MD; Cheri Frey, MD; Neda F. Gould, PhD; Nishant Gupta, MD; Sarthak Gupta, MD; Sarfaraz Hasni, MD; David Hunt, MD; Mariana J. Kaplan, MD; Alfred Kim, MD; Deborah Lyu Kim, DO; Rukmini Konatalapalli, MD; Fotios Koumpouras, MD; Vasileios C. Kyttaris, MD; Jerik Leung, MPH; Hector A. Medina, MD; Timothy Niewold, MD; Julie Nusbaum, MD; Ginette Okoye, MD; Sarah L. Patterson, MD; Ziv Paz, MD; Darryn Potosky, MD; Rachel C. Robbins, MD; Neha S. Shah, MD; Matthew A. Sherman, MD; Yevgeniy Sheyn, MD; Julia F. Simard, ScD; Jonathan Solomon, MD; Rodger Stitt, MD; George Stojan, MD; Sangeeta Sule, MD; Barbara Taylor, CPPM, CRHC; George Tsokos, MD; Ian Ward, MD; Emma Weeding, MD; Arthur Weinstein, MD; Sean A. Whelton, MD

xv From the Old to the New xvii Acknowledgments xxi 1 Verilog - A Tutorial Introduction 1 Getting Started 2 A Structural Description 2 Simulating the binaryToESeg Driver 4 Creating Ports For the Module 7 Creating a Testbench For a Module 8 11 Behavioral Modeling of Combinational Circuits Procedural Models 12 Rules for Synthesizing Combinational Circuits 13 14 Procedural Modeling of Clocked Sequential Circuits Modeling Finite State Machines 15 Rules for Synthesizing Sequential Systems 18 Non-Blocking Assignment ("

The Verilog language is a hardware description language which provides a means of specifying a digital system at a wide range of levels of abstraction. The language supports the early conceptual stages of design with its behavioral level of abstraction, and the later implementation stages with its structural level of abstraction. The language provides hierarchical constructs, allowing the designer to control the complexity of a description. Verilog was originally designed in the winter of 1983/84 as a proprietary verification/simulation product. Since then, several other proprietary analysis tools have been developed around the language, including a fault simulator and a timing analyzer; the language being instrumental in providing consistency across these tools. Now, the language is openly available for any tool to read and write. This book introduces the language. It is sometimes difficult to separate the language from the simulator tool because the dynamic aspects of the language are defined by the way the simulator works. Where possible, we have stayed away from simulator-specific details and concentrated on design specification, but have included enough information to be able to have working executable models. The book takes a tutorial approach to presenting the language.

Recently there has been increased interest in the development of computer-aided design programs to support the system level designer of integrated circuits more actively. Such design tools hold the promise of raising the level of abstraction at which an integrated circuit is designed, thus releasing the current designers from many of the details of logic and circuit level design. The promise further suggests that a whole new group of designers in neighboring engineering and science disciplines, with far less understanding of integrated circuit design, will also be able to increase their productivity and the functionality of the systems they design. This promise has been made repeatedly as each new higher level of computer-aided design tool is introduced and has repeatedly fallen short of fulfillment. This book presents the results of research aimed at introducing yet higher levels of design tools that will inch the integrated circuit design community closer to the fulfillment of that promise. 1. 1. SYNTHESIS OF INTEGRATED CmCUITS In the integrated circuit (Ie) design process, a behavior that meets certain specifications is conceived for a system, the behavior is used to produce a design in terms of a set of structural logic elements, and these logic elements are mapped onto physical units. The design process is impacted by a set of constraints as well as technological information (i. e. the logic elements and physical units used for the design).

Systemic lupus erythematosus is an autoimmune disease that can affect any system and organ in the body. For the 1.4 million people in the United States who have lupus, an overactive immune system senses that different parts of the body do not belong, and it attacks these parts. The immune system may strike the cells that line the joints or tendons, for example, causing pain and swelling. An incredibly complex disease, lupus must be properly treated for the optimal health and well-being of the person who has it. The Lupus Encyclopedia is an authoritative compendium that provides detailed explanations of every body system potentially affected by the disease, along with practical advice about coping. People with lupus, their loved ones, caregivers, and medical professionals-all will find here an invaluable resource. Illustrated with photographs, diagrams, and tables, The Lupus Encyclopedia explains symptoms, diagnostic methods, medications and their potential side effects, and when to seek medical attention. Dr. Donald Thomas provides information for women who wish to become pregnant and advises readers about working with a disability, complementary and alternative medicine, infections, cancer, and a host of other topics.

xv From the Old to the New xvii Acknowledgments xxi 1 Verilog - A Tutorial Introduction 1 Getting Started 2 A Structural Description 2 Simulating the binaryToESeg Driver 4 Creating Ports For the Module 7 Creating a Testbench For a Module 8 11 Behavioral Modeling of Combinational Circuits Procedural Models 12 Rules for Synthesizing Combinational Circuits 13 14 Procedural Modeling of Clocked Sequential Circuits Modeling Finite State Machines 15 Rules for Synthesizing Sequential Systems 18 Non-Blocking Assignment ("

Recently there has been increased interest in the development of computer-aided design programs to support the system level designer of integrated circuits more actively. Such design tools hold the promise of raising the level of abstraction at which an integrated circuit is designed, thus releasing the current designers from many of the details of logic and circuit level design. The promise further suggests that a whole new group of designers in neighboring engineering and science disciplines, with far less understanding of integrated circuit design, will also be able to increase their productivity and the functionality of the systems they design. This promise has been made repeatedly as each new higher level of computer-aided design tool is introduced and has repeatedly fallen short of fulfillment. This book presents the results of research aimed at introducing yet higher levels of design tools that will inch the integrated circuit design community closer to the fulfillment of that promise. 1. 1. SYNTHESIS OF INTEGRATED CmCUITS In the integrated circuit (Ie) design process, a behavior that meets certain specifications is conceived for a system, the behavior is used to produce a design in terms of a set of structural logic elements, and these logic elements are mapped onto physical units. The design process is impacted by a set of constraints as well as technological information (i. e. the logic elements and physical units used for the design).

1. Verilog - A Tutorial Introduction.- 1.1 Describing Digital Systems.- 1.2 Getting Started.- 1.2.1 A Structural Description.- 1.2.2 Simulating the NAND Latch.- 1.3 Module Hierarchy.- 1.3.1 The Counter.- 1.3.2 Components of the Counter.- 1.3.3 A Clock for the System.- 1.3.4 Tying the Whole Circuit Together.- 1.4 Behavioral Modeling.- 1.4.1 A Behavioral Model of the m16 Counter.- 1.4.2 Mixing Structure and Behavior.- 1.4.3 Assignment Statements.- 1.4.4 Mixing Behavioral and Structural Descriptions.- 1.5 Summary.- 1.6 Exercises.- 2. Behavioral Modeling Constructs.- 2.1 Process Model.- 2.2 If-Then-Else.- 2.2.1 Where Does The ELSE Belong?.- 2.2.2 The Conditional Operator.- 2.3 Loops.- 2.3.1 Four Basic Loop Statements.- 2.3.2 Exiting Loops on Exceptional Conditions.- 2.4 Multi-way branching.- 2.4.1 If-Else-If.- 2.4.2 Case.- 2.4.3 Comparison of Case and If-Else-If.- 2.4.4 CaseZ and CaseX.- 2.5 Functions and Tasks.- 2.5.1 Tasks.- 2.5.2 Functions.- 2.5.3 A Structural View.- 2.6 Summary.- 2.7 Exercises.- 3. Concurrent Process Statements.- 3.1 Concurrent Processes.- 3.2 Events.- 3.2.1 Event Control Statement.- 3.2.2 Named Events.- 3.2.3 An Example of Hierarchical Names.- 3.3 The Wait Statement.- 3.3.1 A Complete Producer-Consumer Handshake.- 3.3.2 Comparison of the Wait and While Statements.- 3.3.3 Comparison of Wait and Event Control Statements.- 3.4 Disabling Named Blocks.- 3.5 Quasi-continuous assignment.- 3.6 Sequential and Parallel Blocks.- 3.7 Exercises.- 4. Logic Level Modeling.- 4.1 Introduction.- 4.2 Logic Gates and Nets.- 4.2.1 Modeling Using Primitive Logic Gates.- 4.2.2 Four-Level Logic Values.- 4.2.3 Nets.- 4.2.4 Module Port Specifications.- 4.3 Continuous Assignment.- 4.3.1 Behavioral Modeling of Combinational Circuits.- 4.3.2 Net and Continuous Assign Declarations.- 4.4 Parameterized Definitions.- 4.5 Logic Delay Modeling.- 4.5.1 A Gate Level Modeling Example.- 4.5.2 Gate and Net Delays.- 4.5.3 Minimum, Typical, and Maximum Delays.- 4.6 Delay Paths Across a Module.- 4.7 Summary.- 4.8 Exercises.- 5. Defining Gate Level Primitives.- 5.1 Combinational Primitives.- 5.1.1 Basic Features of User-Defined Primitives.- 5.1.2 Describing Combinational Logic Circuits.- 5.2 Level- and Edge-Sensitive Sequential Primitives.- 5.2.1 Level-Sensitive Primitives.- 5.2.2 Edge-Sensitive Primitives.- 5.3 Shorthand Notation.- 5.4 Mixed Level- and Edge-Sensitive Primitives.- 5.5 Summary.- 5.6 Exercises.- 6. Switch Level Modeling.- 6.1 A Dynamic MOS Shift Register Example.- 6.2 Switch Level Modeling.- 6.2.1 Strength Modeling.- 6.2.2 Strength Definitions.- 6.2.3 An Example Using Strengths.- 6.2.4 Resistive MOS Gates.- 6.3 Ambiguous Strengths.- 6.3.1 Illustrations of Ambiguous Strengths.- 6.3.2 The Underlying Calculations.- 6.4 Summary.- 6.5 Exercises.- 7. Two Large Examples.- 7.1 The miniSim Example.- 7.1.1 Overview.- 7.1.2 The miniSim Source.- 7.1.3 Simulation Results.- 7.2 The 8251A Example.- 7.2.1 Overview.- 7.2.2 The 8251A Source.- 7.3 Exercises.- Appendix A. Lexical Conventions.- A.1 White Space and Comments.- A.2 Operators.- A.3 Numbers.- A.4 Strings.- A.5 Identifiers, System Names, and Keywords.- Appendix B. Verilog Operators.- B.1 Table of Operators.- B.2 Operator Precedence.- B.3 Operator Truth Tables.- B.3.1 Bitwise AND.- B.3.2 Bitwise OR.- B.3.3 Bitwise XOR.- B.3.4 Bitwise XNOR.- B.4 Expression Bit Lengths.- Appendix C. Verilog Gate Types.- C.1 Logic Gates.- C.2 BUF and NOT Gates.- C.3 BUFIF and NOTIF Gates.- C.4 MOS Gates.- C.5 Bidirectional Gates.- C.6 CMOS Gates.- C.7 Pullup and Pulldown Gates.- Appendix D. Registers, Memories, Integers, and Time.- D.1 Registers.- D.2 Memories.- D.3 Integers and Times.- Appendix E. System Tasks and Functions.- E.1 Display and Write Tasks.- E.2 Continuous Monitoring.- E.3 Strobed Monitoring.- E.4 File Output.- E.5 Simulation Time.- E.6 Stop and Finish.- E.7 Random.- Appendix F. Formal Syntax Definition.- F.1 Source Text.- F.2 Declarations.- F.3 Primitive Instances.- F.4 Module Instantiations.- F.5 B...

A case study of the technological, economic, and intellectual trends during Germany's industrial revolution.

The life of Rudolf Diesel, a man who achieved a power plant with the potential for revolutionizing industry and transportation. Diesel demonstrated that he possessed both the scientific insight and technical skill needed to create the diesel engine.