This book constitutes the thoroughly refereed post-conference proceedings of the 16th International Conference on Information Security and Cryptology, ICISC 2013, held in Seoul, Korea in November 2013. The 31 revised full papers presented together with 2 invited talks were carefully selected from 126 submissions during two rounds of reviewing. The papers provide the latest results in research, development and applications in the field of information security and cryptology. They are organized in topical sections on secure multiparty computation, proxy re-encryption, side channel analysis and its countermeasures, cryptanalysis, embedded system security and its implementation, primitives for cryptography, digital signature, security protocol, cyber security, and public key cryptography.