This issue of Physician Assistant Clinics, guest edited by Donna Seton and Rich Lamkin, is devoted to Hospice and Palliative Care Medicine. Articles in this issue include: Introduction to Hospice and Palliative Care Medicine, The Role of the Physician Assistant in Hospice and Palliative Care Medicine, Breaking Serious News: Communication in Hospice and Palliative Care Medicine, Advance Care Planning and Goals of Care in Hospice and Palliative Care Medicine, Palliative Care and Spirituality, Prognostic Tools in Hospice and Palliative Care Medicine, Basics of Pain Management in Hospice and Palliative Care Medicine, Dyspnea in Hospice and Palliative Care Medicine, Gastrointestinal Symptoms in Hospice and Palliative Care Medicine, Psychiatric Issues in Hospice and Palliative Care Medicine, Pediatric Palliative Care Basics in Hospice and Palliative Care Medicine, and more.