Recent years have witnessed dramatic advances in the development and use of magnetic resonance imaging (MRI) techniques that can provide quantitative measures with some degree of pathological specificity for the heterogeneous substrates of multiple sclerosis (MS). Magnetic resonance spectroscopy (MRS) is one of the most promising of these techniques. Thanks to MRS, axonal damage is no longer considered an end-stage phenomenon typical of only the most destructive lesions and the most unfortunate cases, but rather as a major component of the MS pathology of lesions and normal-appearing white matter at all the phases of the disease. This new concept is rapidly changing our understanding of MS pathophysiology and, as a consequence, the therapeutic strategies to modify the disease course favorably. Many of the authors have pionereed the use of MRS in MS, thus contributing to the foundation of the "axonal hypothesis".

What did the Founding Fathers mean when they wrote the Constitution? What did the right to keep and bear arms or an establishment of religion or the republican form of government mean to the founders? Obviously, as enlightened men of the late eighteenth century, they were familiar with a host of ideas and concepts drawn from ancient political theory as well as contemporary political pamphleteers. However, as our language has evolved the precise meaning of the words of the founders has become obscure as well as misunderstood.

To make the words and concepts used by the founders clear to modern readers, Greene and his colleagues have gone back to the sources known to the founders and excerpted the key passages from these sources that bear on the language and concepts of the Constitution and the Bill of Rights. More than eighty key words are organized in alphabetical order, from accusation to witness. Under each entry, passages from key sources are provided in chronological order from as early as 1215 to December 15, 1791. Augmented by a concordance to the Constitution and a general subject index, "The Language of the Constitution" provides easy access to the key concepts and ideas of the Constitution as the founders understood them. This volume is invaluable for students and legal professionals, including lawyers, legislators, and judges of the state courts (which are now interpreting the federal constitution), as well as the federal courts. It is an essential acquisition for public, school, university, and law school libraries.