Recent years have seen enormous advances in the field of protein and peptide engineering and a greater understanding in the way in which biological response modifiers function in the body. It is now possible through the use of recombinant DNA techniques, or by solid phase protein synthesis, to produce significant quantities of a wide variety of regulatory agents that are therapeutically applicable. The list of these response modifiers expands almost daily to include interferons, macrophage activation factors, neuropeptides and agents that may have potential in cardiovascular disease, inflammation, contraception etc. Prospects to use some of these materials in medicine have reached the stage where products have either been approved by regulatory authorities or are the subject of applications as investigatory drugs or as new therapeutic agents. In some uses the pertinent agent will be administered on an acute basis in the form of a simple injection, as, for example, the use of a tissue plasminogen activator for the treatment of coronary infarct. In other cases regulatory proteins and peptides are indicated for chronic therapy and here they will need to be administered by an appropriate delivery system. Unfortunately, the research on delivery systems for peptides and proteins has not kept pace with the rapid progress in biotechnology and, consequently, there are presently few systems that are entirely appropriate for the administration of macromolecular drugs according to complex dosage regimens, (eg intermittent and pulsed therapy). Furthermore essential pharmacokinetic and pharmacodynamic data may be missing.

Recent years have seen enormous advances in the field of protein and peptide engineering and a greater understanding in the way in which biological response modifiers function in the body. It is now possible through the use of recombinant DNA techniques, or by solid phase protein synthesis, to produce significant quantities of a wide variety of regulatory agents that are therapeutically applicable. The list of these response modifiers expands almost daily to include interferons, macrophage activation factors, neuropeptides and agents that may have potential in cardiovascular disease, inflammation, contraception etc. Prospects to use some of these materials in medicine have reached the stage where products have either been approved by regulatory authorities or are the subject of applications as investigatory drugs or as new therapeutic agents. In some uses the pertinent agent will be administered on an acute basis in the form of a simple injection, as, for example, the use of a tissue plasminogen activator for the treatment of coronary infarct. In other cases regulatory proteins and peptides are indicated for chronic therapy and here they will need to be administered by an appropriate delivery system. Unfortunately, the research on delivery systems for peptides and proteins has not kept pace with the rapid progress in biotechnology and, consequently, there are presently few systems that are entirely appropriate for the administration of macromolecular drugs according to complex dosage regimens, (eg intermittent and pulsed therapy). Furthermore essential pharmacokinetic and pharmacodynamic data may be missing.

How far would you go to seal the ultimate deal?

In Richard E. Tomlinson's case, it seemed that nothing could get in his way. But his hubris would lead him to some disastrous results.

His confidence bolstered by his previous successes in broadcasting, marketing, and finance, this seasoned businessman decides to travel into uncharted territory. So he develops a worldwide enterprise in a business he has absolutely no experience in: Black Angus cattle.

After partnering up with the largest Angus breeder in the country, Tomlinson's new enterprise takes him from the UK to Hungary to Belize.

However, things at home aren't what they seem, and Tomlinson soon finds himself resorting to some very desperate measures to save his $22 million European deal.

Comprising a ten-year slice in the middle of his career, "Hustling With Hubris" is the autobiographical story of Tomlinson's unique business experience and the tough lessons he learned along the way.

Whether you're a business or law student seeking to learn from someone else's experience, or you're just looking for an entertaining true story, this gripping account contains plenty of twists and turns-as well as a surprise ending you won't forget

Caregiver's Compass informs caregivers and foster parents about the juvenile court process while providing a guide for tracking necessary activities during foster care.