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The intestine is among the leading organs, in which several cutting
edge in vitro and in vivo research tools and approaches have
recently been developed and used to investigate stem cell
biology/function, and the potential applications of stem cells in
the treatment of intestinal diseases. These cutting-edge research
tools and approaches involve human and murine organoid cultures,
genetic editing in vitro and in vivo, human induced pluripotent
cell (iPS cell) models of disease, haploid cells for genetic as
well as compound screening paradigms, genetically engineered mice,
and stem cell transplantation to cure diseases. Stem Cell
Innovation in Health and Disease: Volume 1: The Intestine contains
two major sections describing cutting edge research for
understanding stem cell functions in the intestine, and for
developing methods to bring stem cells from bench to bedside;
respectively. Each section includes insights ranging from using
mouse and human organoid cultures, genetic editing in vitro and in
vivo, and human induced pluripotent cells (iPSCs) to study stem
cell functions and model intestinal diseases, through the
cutting-edge research, including the potential application of
iPSCs, ESCs and blood stem cells (stem cell transplants) in the
treatment of intestinal diseases/disorders. This volume, therefore,
discusses the fact-based promise of stem cells and regenerative
medicine in the intestine in the real world.
With detailed scientific background and up-to-date research, this
book examines recent developmental and cell biology, mechanobiology
and stem cell biology discoveries to help provide a better
understanding of lung development, repair and regeneration.Lung
regeneration is an urgent therapeutic priority. The current major
challenge is the generation of complex vascularized structures that
can ultimately support or replace impaired lung function. Recent
discoveries in biomedical engineering are analysed within the
structural context of the lung to help provide a better
understanding of the innovative solutions that could be used for
restoring normal morphogenesis and regeneration of the lung. This
also includes insights from basic developmental mechanisms of human
lung development through the derivation and identification of stem
cells, both from the early embryo as well as from differentiated
organs and tissues.Suitable for a wide range of readers, including
physicians and surgeons, scientists and researchers, and
undergraduate and postgraduate students, this guide is an essential
read for those working in the field of lung disease and
development.
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