Substance Abuse and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on research methodologies for substance abuse and addiction that is intended for researchers and consumers of research information at all levels. The book is divided into four major sections, including an Introduction, Research Methodology for clinical trials, animal research and retrospective studies, Mechanisms of Abuse and Addiction, and Investigative Therapeutics: Designing and Measuring Outcomes. It serves a source for addressing all aspects of research design, methods and analysis within the context of the field of opioids, alcohol and other substances. The book covers what is known in the field of quantitative and qualitative research methods, provides future directions, and introduces new models for investigation. It is organized around a translational science framework, with the contents addressing substance use/addiction research in the context of epidemiology, etiology, intervention efficacy and effectiveness, and implementation of evidence-informed interventions.

For years the administrative of anesthesia was extremely dangerous and risky. Because of this the surgeon and anesthesiologist had to balance the risks and benefits for each patient before proceeding with surgery. In the last two decades the care of the surgical patient has changed dramatically. New equipment, monitors and pharmacologic agents have transformed surgical technique and improved outcomes. Patients once deemed "too sick" for the operating room are found frequently on operating room schedules nationwide. Today, anesthesiology for the healthy patient in most developed countries is extremely safe. However, perioperative complications still occur. These events can be catastrophic for patients and may have serious implications for residents, surgical and anesthesiology staff and nurses. Prompt recognition and management of these incidents may reduce or negate complications. This is based on a fundamental base of knowledge acquired through several avenues and practiced with other team members to maximize outcomes. Engagement of all caregivers impacts outcomes. Many organizations do not have the structural components or education to recognize or manage these catastrophic events. This textbook will provide educational material for the many students, as well as nurses, residents or attending physicians who participate in perioperative medicine. It will focus on the most serious perioperative complications and include a discussion of the pathophysiologic and pharmacologic implications unique to each. Additionally, it will provide medicolegal information pertinent to those providing care to these patients. All chapters will be written with the most current and relevant information by leading experts in each field.The layout and format is designed to be purposeful, logical and visually effective. Other features include review questions and answers, chapter summaries and shaded call-out boxes to facilitate learning. Catastrophic Perioperative Complications and Management will be of great utility for medical and nursing students, anesthesiology residents, student nurse anesthestists, surgical residents, nurses involved in perioperative medicine as well as surgical and anesthesiology attending physicians.