This exciting and innovative Handbook provides readers with a comprehensive and globally relevant overview of the instruments, actors and design features of social protection systems, as well as their application and impacts in practice. It is the first book that centres around system building globally, a theme that has gained political importance yet has received relatively little attention in academia. Combining academic discussion with cases from the Global South and North, this Handbook offers practical recommendations on how greater harmonization across social protection policies, programmes and delivery mechanisms can be achieved. It also highlights the importance of linkages to other policy fields and issues such as taxation, humanitarian aid and livelihood approaches. Overall, the chapters argue that a systems approach is needed to respond to the individual needs of different groups in society and to face future challenges from demographic change, globalization, automation, climate change and pandemics. Targeting a broad audience, the Handbook on Social Protection Systems bridges the divide in academic debate around social protection in the Global South and North. It will be an invaluable resource for academics, students and practitioners.