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Regenerative Medicine in the Genitourinary System gives the reader
a comprehensive overview of tissue engineering used to treat
genitourinary disorders and infertility, also providing a great
learning platform for researchers in different fields such as cell
biology, pharmaceutics, clinicians, chemists, material scientists,
and more. The book covers the latest innovations on the subject,
but also acts as a resource for tissue engineering applications and
regenerative medicine. Over the last several decades, tissue
engineering has continued to make considerable advancements in
therapeutic and clinical strategies that address male/female
urological or genitourinary diseases. Although several articles
have been published on this topic, there are very few book chapters
and no single book currently available dedicated to this topic.
Principles of Biomaterials Encapsulation: Volume Two provides an
expansive and in-depth resource covering the key principles,
biomaterials, techniques and applications of encapsulation in
translational medicine. The book details the various biomaterials
available for encapsulation, including polymers, natural and
synthetic biomaterials, porous materials, and more. The advantages
and disadvantages of conventional and contemporary biomaterials for
encapsulations are reviewed, along with advice on the most
effective materials for both shell and core. The final part of the
book describes a broad range of applications in regenerative
medicine, uniquely bringing encapsulation into the worlds of
translational medicine and tissue engineering. This book enables
readers to learn about the pros and cons of different biomaterials
for encapsulation, as well as how they can be utilized in many
bodily systems and tissues, such as the respiratory, digestive,
endocrine and cardiovascular systems. Written and edited by
well-versed materials scientists with extensive clinical,
biomedical and regenerative medicine experience, this book offers a
deeply interdisciplinary look at encapsulation in translational
medicine.
Principles of Biomaterials Encapsulation: Volume One, provides an
expansive and in-depth resource covering the key principles,
biomaterials, strategies and techniques for encapsulation. Volume
One begins with an introduction to encapsulation, with subsequent
chapters dedicated to a broad range of encapsulation principles and
techniques, including spray chilling and cooling, microemulsion,
polymerization, extrusion, cell microencapsulation and much more.
This book methodically details each technique, assessing the
advantages and disadvantages of each, allowing the reader to make
an informed decision when using encapsulation in their research.
Principles of Biomaterials Encapsulation: Volume One enables
readers to learn about the various strategies and techniques
available for encapsulation of a wide selection of biomedical
substrates, such as drugs, cells, hormones, growth factors and so
on. Written and edited by well-versed materials scientists with
extensive clinical, biomedical and regenerative medicine
experience, this book offers a deeply interdisciplinary look at
encapsulation in translational medicine. As such, this book will
provide a useful resource to a broad readership, including those
working in the fields of materials science, biomedical engineering,
regenerative and translational medicine, pharmacology, chemical
engineering and nutritional science.
Advanced Dental Biomaterials is an invaluable reference for
researchers and clinicians within the biomedical industry and
academia. The book can be used by both an experienced
researcher/clinician learning about other biomaterials or
applications that may be applicable to their current research or as
a guide for a new entrant into the field who needs to gain an
understanding of the primary challenges, opportunities, most
relevant biomaterials, and key applications in dentistry.
Handbook of Tissue Engineering Scaffolds: Volume Two provides a
comprehensive and authoritative review on recent advancements in
the application and use of composite scaffolds in tissue
engineering. Chapters focus on specific tissue/organ (mostly on the
structure and anatomy), the materials used for treatment, natural
composite scaffolds, synthetic composite scaffolds, fabrication
techniques, innovative materials and approaches for scaffolds
preparation, host response to the scaffolds, challenges and future
perspectives, and more. Bringing all the information together in
one major reference, the authors systematically review and
summarize recent research findings, thus providing an in-depth
understanding of scaffold use in different body systems.
Handbook of Tissue Engineering Scaffolds: Volume One, provides a
comprehensive and authoritative review on recent advancements in
the application and use of composite scaffolds in tissue
engineering. Chapters focus on specific tissue/organ (mostly on the
structure and anatomy), the materials used for treatment, natural
composite scaffolds, synthetic composite scaffolds, fabrication
techniques, innovative materials and approaches for scaffolds
preparation, host response to the scaffolds, challenges and future
perspectives, and more. Bringing all the information together in
one major reference, the authors systematically review and
summarize recent research findings, thus providing an in-depth
understanding of scaffold use in different body systems.
Bone repair is modulated by different stimuli. There is evidence
that the Transforming Growth Factor-beta (TGF- ) super-family of
cytokines have significant effects on bone structure by regulating
the replication and differentiation of chondrocytes, osteoblasts
and osteoclasts. This book aimed at determining the role of the
TGF- s, Collagen type I, Fibronectin and Laminin in bone cell
behaviour. To do this MG-63 bone cells were used to examine cell
adhesion and alignment to different micro-contact printed ECM
protein patterns of different widths. The study also aimed at
examining how various TGF- isomers (TGF- 1, 2 and 3) and their
solvent and carrier (HCl and BSA, respectively) effected cell
surface interactions, cell morphology, cell proliferation and
integrin expression. Finally, this study also aimed at examining
how the TGF- s and their solvent and carrier influenced wound
closure in an in vitro wound closure model and how TGF- s influence
ECM secretion and integrin expression."
Bone Tissue Engineering is a promising field that helps human needs
by applying the principles of biology and engineering to the
development of feasible substitutes that restore and retain the
function of human bone tissues. The live cells in the body attach
to the normal scaffold known as extracellular matrix but in
in-vitro studies presence of a scaffold is essential to keep cells
alive. Therefore, good cell adhesion on scaffolds is essential for
successful tissue engineering. The aim of this book is to identify
the key factors of coating which leads to better cell adhesion and
to establish the relationship of cells' adhesion and the treatment
of substrates. Another aim is to apply four-point bending system to
stimulate bone cells and finally evaluate bone cells' response to
the mechanical stimuli on different substrates by morphology
alteration using histological and immunological staining methods.
Human bone cell line (MG-63) and rat primary bone cells were used
in this study. Two-dimensional substrates were used as a scaffold
model. The selected substrates included PLLA, PLLA coated with
PDLLA-b-PEO co-polymer, collagen coated, RGD grafted PLLA-PEO
coated substrates.
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