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This handbook discusses developments and the future of gout
treatment, which looks promising. Gout has been a well-known
disease for over 2000 years, and is the most common cause of joint
inflammation in adult males. It has become apparent that no
therapeutic target based on hyperuricemia outcome had been defined.
Very few controlled trials were available to test the efficacy and
safety of treatments, and no research on diagnosis and management
had been done despite data showing that patients with gout were
generally improperly treated even in the hands of specialists. In
the last 10 years, good-quality evidence on gout impact and
management has grown exponentially, renal transporters have been
recently identified, and a number of new drugs have been approved
or are under current development.
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