This volume aims to advance the analysis about Amerigo Vespucci by considering and connecting several fields of study such as literary history, philology, the history of science and cartography, economic history, and the history of ideas. The multifaceted research frames guide the reader through the complex vicissitudes of Amerigo Vespucci's life. The receptions and implications explore the intense cultural and historical dynamics that shaped the decades between the end of the fifteenth and the first half of the sixteenth century.