The articles collected in this volume are based on lectures given at the IMA Workshop, "Computational Radiology and Imaging: Therapy and Diagnostics", March 17-21, 1997. Introductory articles by the editors have been added. The focus is on inverse problems involving electromagnetic radiation and particle beams, with applications to X-ray tomography, nuclear medicine, near-infrared imaging, microwave imaging, electron microscopy, and radiation therapy planning. Mathematical and computational tools and models which play important roles in this volume include the X-ray transform and other integral transforms, the linear Boltzmann equation and, for near-infrared imaging, its diffusion approximation, iterative methods for large linear and non-linear least-squares problems, iterative methods for linear feasibility problems, and optimization methods. The volume is intended not only for mathematical scientists and engineers working on these and related problems, but also for non-specialists. It contains much introductory expository material, and a large number of references. Many unsolved computational and mathematical problems of substantial practical importance are pointed out.

The conference was devoted to the discussion of present and future techniques in medical imaging, including 3D x-ray CT, ultrasound and diffraction tomography, and biomagnetic ima- ging. The mathematical models, their theoretical aspects and the development of algorithms were treated. The proceedings contains surveys on reconstruction in inverse obstacle scat- tering, inversion in 3D, and constrained least squares pro- blems.Research papers include besides the mentioned imaging techniques presentations on image reconstruction in Hilbert spaces, singular value decompositions, 3D cone beam recon- struction, diffuse tomography, regularization of ill-posed problems, evaluation reconstruction algorithms and applica- tions in non-medical fields. Contents: Theoretical Aspects: J.Boman: Helgason' s support theorem for Radon transforms-a newproof and a generalization -P.Maass: Singular value de- compositions for Radon transforms- W.R.Madych: Image recon- struction in Hilbert space -R.G.Mukhometov: A problem of in- tegral geometry for a family of rays with multiple reflec- tions -V.P.Palamodov: Inversion formulas for the three-di- mensional ray transform - Medical Imaging Techniques: V.Friedrich: Backscattered Photons - are they useful for a surface - near tomography - P.Grangeat: Mathematical frame- work of cone beam 3D reconstruction via the first derivative of the Radon transform -P.Grassin, B.Duchene, W.Tabbara: Dif- fraction tomography: some applications and extension to 3D ultrasound imaging -F.A.Gr}nbaum: Diffuse tomography: a re- fined model -R.Kress, A.Zinn: Three dimensional reconstruc- tions in inverse obstacle scattering -A.K.Louis: Mathemati- cal questions of a biomagnetic imaging problem - Inverse Problems and Optimization: Y.Censor: On variable block algebraic reconstruction techniques -P.P.Eggermont: On Volterra-Lotka differential equations and multiplicative algorithms for monotone complementary problems

Nowadays we are facing numerous and important imaging problems: nondestructive testing of materials, monitoring of industrial processes, enhancement of oil production by efficient reservoir characterization, emerging developments in noninvasive imaging techniques for medical purposes - computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), X-ray and ultrasound tomography, etc. In the CIME Summer School on Imaging (Martina Franca, Italy 2002), leading experts in mathematical techniques and applications presented broad and useful introductions for non-experts and practitioners alike to many aspects of this exciting field. The volume contains part of the above lectures completed and updated by additional contributions on other related topics.

This book provides a unified view of tomographic techniques, a common mathematical framework, and an in-depth treatment of reconstruction algorithms. It focuses on the reconstruction of a function from line or plane integrals, with special emphasis on applications in radiology, science, and engineering. The Mathematics of Computerized Tomography covers the relevant mathematical theory of the Radon transform and related transforms and also studies more practical questions such as stability, sampling, resolution, and accuracy. Quite a bit of attention is given to the derivation, analysis, and practical examination of reconstruction algorithms, for both standard problems and problems with incomplete data.

Since the advent of computerized tomography in radiology, many imaging techniques have been introduced in medicine, science, and technology. This book describes the state of the art of the mathematical theory and numerical analysis of imaging. The authors survey and provide a unified view of imaging techniques, provide the necessary mathematical background and common framework, and give a detailed analysis of the numerical algorithms. This book not only reflects the theoretical progress and the growth of the field in the last 10 years but also serves as an excellent reference. It will provide readers with a superior understanding of the mathematical principles behind imaging and will enable them to write state-of-the-art software as a result. Mathematical Methods in Image Reconstruction provides a very detailed description of two-dimensional algorithms. For three-dimensional algorithms, the authors derive exact and approximate inversion formulas for specific imaging devices and describe their algorithmic implementation (which by and large parallels the two-dimensional algorithms). Integral geometry is surveyed as far as is necessary for imaging purposes; imaging techniques based on or related to integral geometry are briefly described in the section on tomography. Some of the applications covered in the book include computerized tomography, magnetic resonance imaging, emission tomography, electron microscopy, ultrasound transmission tomography, industrial tomography, seismic tomography, impedance tomography, and NIR imaging. The authors provide the necessary mathematical background and common mathematical framework needed to understand the book. Knowledge of tomography literature from the 1980s will be useful to the reader.