This book covers the basic physics, biomedical engineering, and clinical applications of focused ultrasound therapy, the first book to do so. Focusing on applications in cancer treatment, it reviews the medical physics and bio-effects of focused ultrasound beams on living tissues, dosimetry methods and measurements, image guidance including MRI and ultrasound, treatment delivery systems, and clinical applications. It also gives practical guidelines on patient setup, target localization, treatment planning, and image-guided procedures for the treatment of various tumors.