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Osteoimmunology: Interactions of the Immune and Skeletal Systems,
Second Edition, explores the advancements that have been made in
the field during the last 40 years, including valuable information
on our understanding of the interactions between hematopoietic,
immune, and bone cells, now known as the field of osteoimmunology.
This comprehensive work offers the most extensive summaries of
research trends in the field and their translation into new
therapeutics. Early chapters deal with the development of
osteoblasts, osteoclasts, hematopoietic stem cells, T and
B-lymphocytes, and communications between these cellular elements,
while later sections contain discussions of the signaling pathways
by which RANKL influences osteoclast development and function.
Subsequent chapters explore the effects that estrogen has on bone
and the immune system, the development of pathologic conditions,
and the growing research around osteoporosis, Paget's disease, the
genetics of bone disease, and bone cancer metastasis.
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