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"Advances in Down Syndrome Research represents updated research in
several areas of Down Syndrome (DS). A new promising animal model
of DS is reported and this opens new opportunities to study
pathomechanisms and pharmacological approaches as it is more than
difficult to carry out studies in humans and the clinical features
are highly variable. In terms of biology, cell cycle and stem cell
studies and in terms of biochemistry, relevance of studies on a
specific protein kinase, channels, transporters, superoxide
dismutase, antioxidant system, chromosome assembly factor and other
important biological structures are provided. And again, the gene
dosage hypothesis is addressed and although the vast majority of
chromosome 21 gene products is unchanged in fetal DS brain, a few
specific chromosome 21 encoded structures including transcription
factors are indeed overexpressed although findings in fetal DS are
different from those in adult DS brain when Alzheimer-like
neuropathology supervenes."
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