Metamaterials-by-Design: Theory, Technologies, and Vision is devoted to a comprehensive review of the latest advancements and current trends in the field of system-level-oriented metamaterial design methods, technologies, and future perspectives. Starting from the theoretical and methodological motivations of this research to macro-scale performance-driven design of volumetric and planar metamaterials, the book introduces advanced task-oriented modeling approaches, including specific reference to their multi-scale/ multi-physics customization in recent metamaterial science and engineering. In the introduction of these concepts, particular attention is paid to the illustration of the physical mechanisms and phenomena at the basis of the field manipulation capabilities enabled by metamaterials. Contributions from industry and academic perspectives on active and passive metamaterial-enhanced devices for communications and sensing are included. The final part of the volume is aimed at providing a perspective regarding the current trends, future research and application tracks in system-performance-driven metamaterial design methodologies and technologies, included potential applications in future reconfigurable and cognitive materials.