The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways.

Adeptly navigating one of the most pressing issues on the current global agenda, this topical Research Handbook provides a comprehensive and research-based exploration of the sociology of migration. As well as highlighting the field’s achievements and current challenges, it explores key concepts used in current research, methods employed, and the spheres and contexts in which migrants participate. Presenting an open and pluralistic approach to international migration, this Research Handbook offers a wealth of conceptual analysis, featuring insightful contributions from over 40 leading scholars. Split into three thematic sections, it expertly examines a wide range of theoretical terms, research methods and techniques, and provides an in-depth analysis of the significant work that has been carried out to date in relation to migration. It ultimately sheds light on important discussions surrounding the origins of the sociology of migration, considering not only past events, but also future directions of research for this ever-evolving field of study. Offering a unique and forward-thinking perspective, this authoritative Handbook will serve as a fundamental reference for students, scholars, and practitioners in the fields of sociology and social policy, development studies, and political science, as well as in the wider social sciences.

This timely book critically examines the European Social Model as a contested concept and concrete set of European welfare and governance arrangements. It offers a theoretical and empirical analysis of new economic models and existing European investment strategies to address key issues within post-Covid-19 Europe. The authors explore the structural inequalities that have been shaped by strong imbalances in the relationship between public health, work, formal and informal care, inequality, poverty and the labour market across Europe. They then assess the potential of new economic models and measures, when combined with existing European governance and collaborative welfare arrangements, to repair the European Social Model. With a particular focus on policy measures that affect young and older people in Europe, chapters also provide a critical insight into the fragmented, multi-actor and multidimensional process of building a European social space that has led to the hybridization of welfare systems. Offering a firm theoretical foundation to the understanding of European welfare arrangements and the social open method of coordination, this book will be a valuable resource for academics and students of European social policy, comparative social policy and European governance. Its analysis of empirical evidence relating to the implementation of policy measures will also be beneficial for policymakers and practitioners working in health, social care and welfare fields.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.