The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways.

The Progress in Brain Research series highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Morlun, a vampiric, nigh-unstoppable force of evil, and his deadly family are hunting Spider-Heroes throughout the Multiverse! It will take EVERY SPIDER-MAN EVER to save the day! Collecting: Amazing Spider-Man (2014) #9-15

Nanotechnologies and Nanomaterials for Diagnostic, Conservation and Restoration of Cultural Heritage explores how advanced nanoscale techniques can help preserve artworks. The book covers lab-scale available techniques as well as advanced methods from neutron sources and X-ray spectroscopy. Other sections highlight a variety of nanomaterials with potential uses in treatments for restoration and conservation, with conservation, consolidation and long-term protection protocols analyzed in each case. The final chapter presents case studies, demonstrates how nanoscale techniques are used to conserve art, and shows what happens when misinterpretation of data sources leads to misdiagnosis. The book is intended for scientists from academic and professional conservators, restorers who are involved in the conservation of artistic and historical artifacts, and those who want to learn how nanotechnology can increase the efficiency of conservation and protection techniques.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.