Accessible and user-friendly, Cell Biology, 4th Edition, provides a strong foundation for students entering health care career paths as well as higher level research areas. Clear, readable text and high-quality, detailed illustrations help readers quickly grasp challenging content-all focusing on cellular processes without delving into molecular processes. Drs. Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz, and author/illustrator Dr. Graham Johnson have thoroughly updated this popular text to ensure its relevance for students in biology, biotechnology, medicine, and pathophysiology, covering key principles of cellular function and explaining how molecular defects lead to cellular dysfunction and cause human disease. Clear, readable explanations provide a concise story about how cells function at the molecular level. An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology. Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases. Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation. Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Francis Poulenc (1899-1963) is widely acknowledged as one of the twentieth century's most significant masters of vocal music-solo, choral and operatic-quite apart from his achievements in instrumental spheres. But what it cost him has been underestimated. In this seminal biography, which will serve as the definitive guide to the songs, Graham Johnson shows that it is in Poulenc's extraordinary songs and seeing how they fit into his life-his hidden sexuality, addiction and all-that we discover the composer's essential artistic being. With Jeremy Sams's song translations, the first in over forty years, and the insight that comes from a lifetime of performing this music, Johnson provides an essential volume for singers, pianists, listeners and readers interested in the artistic milieu of modernism in the first half of the twentieth century.

This collection of eight 'lectures' by internationally acclaimed pianist, Graham Johnson, is based on a series of concert talks given at the Guildhall School of Music and Drama as part of the Benjamin Britten festival in 2001. The focus of the book is on Britten's songs, starting with his earliest compositions in the genre. Graham Johnson suggests that the nature of Britten's creativity is especially apparent in his setting of poetry, that he becomes the poet's alter-ego. A chapter on Britten's settings of Auden and Eliot explores the particular influences these writers brought to bear at opposite poles of the composer's life. The inspiration of fellow musicians is also discussed, with a chapter devoted to Britten's time in Russia and his friendship with the Rostropovitch family. Closer to home, the book places in context Britten's folksong settings, illustrating how he subverted the English folksong tradition by refusing to accept previous definitions of what constituted national loyalty. Drawing on letters and diaries, and featuring a number of previously unpublished photographs, this book illuminates aspects of Britten's songs from the personal perspective of the pianist who worked closely with Peter Pears after Benjamin Britten was unable to perform through illness. Johnson worked with Pears on learning the role of Aschenbach in 'Death in Venice' and was official pianist for the first master class given by Peter Pears at Snape in 1972.

The career of Gabriel Faure as a composer of songs for voice and piano traverses six decades (1862-1921); almost the whole history of French melodie is contained within these parameters. In the 1860s Faure, the lifelong protege of Camille Saint-SaA"ns, was a suavely precocious student; he was part of Pauline Viardot's circle in the 1870s and he nearly married her daughter. Pointed in the direction of symbolist poetry by Robert de Montesquiou in 1886, Faure was the favoured composer from the early 1890s of Winnarretta Singer, later Princesse de Polignac, and his songs were revered by Marcel Proust. In 1905 he became director of the Paris Conservatoire, and he composed his most profound music in old age. His existence, steadily productive and outwardly imperturbable, was undermined by self-doubt, an unhappy marriage and a tragic loss of hearing. In this detailed study Graham Johnson places the vocal music within twin contexts: Faure's own life story, and the parallel lives of his many poets. We encounter such giants as Charles Baudelaire and Paul Verlaine, the patrician Leconte de Lisle, the forgotten Armand Silvestre and the Belgian symbolist Charles Van Lerberghe. The chronological range of the narrative encompasses Faure's first poet, Victor Hugo, who railed against Napoleon III in the 1850s, and the last, Jean de La Ville de Mirmont, killed in action in the First World War. In this comprehensive and richly illustrated study each of Faure's 109 songs receives a separate commentary. Additional chapters for the student singer and serious music lover discuss interpretation and performance in both aesthetical and practical terms. Richard Stokes provides parallel English translations of the original French texts. In the twenty-first century musical modernity is evaluated differently from the way it was assessed thirty years ago. Faure is no longer merely a 'Master of Charms' circumscribed by the belle epoque. His status as a great composer of timeless

It was a brutal murder, and the trial of the decade. On 1 November 2007, 21-year-old British student Meredith Kercher was slaughtered in cold blood in the apartment in Perugia, Italy, that she shared with three other girls. Two bright young people, Amanda Knox and her Italian ex-boyfriend, Raffaele Sollecito, stood accused of the killing in a trial that lasted through 2009. They were found guilty and sentenced to twenty-six and twenty-five years respectively on 4 December. A second man, Ivory Coast-born Rudy Guede, 22, had already been found guilty of the sexual assault and murder of Meredith in a separate trial in 2008 and sentenced to thirty years, but the prosecution always stated that he didn't act alone. Kercher was a model student whilst American Knox acquired a reputation that fuelled specualtion about her character. Her bizarre behaviour just after Meredith's body was found, her false accusation of an innocent man, her weak alibi and her DNA on the murder weapon - a kitchen knife found to be scubbed with bleach - went against her. TV producer Paul Russell and critically acclaimed crime writer Graham Johnson have teamed up with leading Italian forensics expert General Luciano Garofano to reveal the full truth behind this sensational murder and its trial. They unravel all the details and study all the personalities in this case that has stunned the world. Complex, and some say controversial, DNA evidence is explained in simple language and, bit by bit, a story emerges of brutality and jealousy in a university town where all was not what it seemed. Their findings make for gripping, sensational reading.

A unique record of Poulenc (1899-1963) who is considered the greatest composer of melodies of his period, a period that opened with the aftermath of the First World War and closed as recently as 1960. He set to music poetry by all the greatest French twentieth century poets as well as others from earlier times. He wrote this diary of songs as an answer to what he felt were the frequent misinterpretations of his work. It describes the origins of each song, comments on performances he heard and offers guidelines for interpretation. The diary is filled out with explanatory notes, a collection of unfamiliar photographs and the English translation to the text written opposite the French original. It will appeal to singers who include French song in his or her repertoire and also to those who have an interest in music of this period. The translator, Winifred Radford is also the singer who gave the first performance in England of Poulenc's song cycle Fiancailles pour rire in 1945. She was coached by Poulenc and Pierre Bernac with whom she later translated The Interpretation of French Song and Francis Poulenc - The Man and his Songs.

This collection of eight 'lectures' by internationally acclaimed pianist, Graham Johnson, is based on a series of concert talks given at the Guildhall School of Music and Drama as part of the Benjamin Britten festival in 2001. The focus of the book is on Britten's songs, starting with his earliest compositions in the genre. Graham Johnson suggests that the nature of Britten's creativity is especially apparent in his setting of poetry, that he becomes the poet's alter-ego. A chapter on Britten's settings of Auden and Eliot explores the particular influences these writers brought to bear at opposite poles of the composer's life. The inspiration of fellow musicians is also discussed, with a chapter devoted to Britten's time in Russia and his friendship with the Rostropovitch family. Closer to home, the book places in context Britten's folksong settings, illustrating how he subverted the English folksong tradition by refusing to accept previous definitions of what constituted national loyalty. Drawing on letters and diaries, and featuring a number of previously unpublished photographs, this book illuminates aspects of Britten's songs from the personal perspective of the pianist who worked closely with Peter Pears after Benjamin Britten was unable to perform through illness. Johnson worked with Pears on learning the role of Aschenbach in 'Death in Venice' and was official pianist for the first master class given by Peter Pears at Snape in 1972.

This collection of imagined book covers will have you scratching your head and laughing out loud with every page turn. Though Pranks with Sausages and Holy Bible II don't actually exist, Rejected Books offers up a professionally produced catalogue of the worst books imaginable, and what these tomes (and plenty more) could look like. Rejected Books includes delightfully weird covers of imagined books like: The Sculptors Who Couldn't Do Hands Cooking with Breast Milk Possessed Toys: A Buying Guide Unfortunate Gluing Accidents Camel Toes Through History Enjoy the worst book pitches of all time and rest assured that anyone can have a future in publishing ... even if your ideas are totally horrible.

Fun and educational, these unique playing cards are beautifully illustrated with detailed cells and cellular structures - perfect for science lovers and cell biologists of all ages! Card faces features favorite illustrations from the textbook Cell Biology by Thomas D. Pollard et al. - from the clathrin triskelion and its three-fold symmetry on the 3 to mitotic chromosome structure on the Queen! Standard 52-card deck with illustrations of echinospherium, seipin ring, muscle thin filament with troponin-tropomyosin, and more. Jokers feature illustrations of cdk2-cyclin A (red joker) and endoplasmic reticulum (black joker). Fourteen different card faces in all featuring the well-loved cellular illustrations of Graham Johnson!

'The young bloods did not care whether they killed criminals or civilians . . .' The Cartel is Britain's biggest drugs gang, a global corporation employing thousands of criminals and flooding Britain with cocaine and heroin. Yet the established order is under threat: street gangs are overwhelming the old-school Cartel godfathers with a campaign of violence, intimidation and mayhem, heralding a series of events that has had devastating consequences for the whole of society. In Young Blood, the explosive follow-up to The Cartel, bestselling true-crime author Graham Johnson reveals how the brutal assassination of drug baron Colin 'King Cocaine' Smith in 2007 by a group of young bucks triggered the rise of the foot soldier, and exposes the bitter struggle that has spread throughout Europe as various factions battle to seize control of the most lucrative crime syndicate in British history.

The French Song Companion is an indispensable guide to French song. 150 composers and 700 song translations make this the ideal handbook both for the seasoned enthusiast, and the newcomer to this endlessly fascinating repertory. Graham Johnson, one of the world's busiest accompanists, brings his wide experience to the biographical commentaries, and Richard Stokes, renowned for his translations of German Lieder, provides line-by-line translations of some of the greatest poems ever set to music.

A global workforce. Billions in sales. But, unlike Tesco or BP, few have heard of it. The Cartel is Britain's biggest drugs organisation, a shadowy network stretching from the freezing, fog-banks of the Mersey to the glittering marinas of Marbella, from the coffee shops of Amsterdam to the trading floors of Canary Wharf. Run by godfathers as rich as Branson but kept in line by a new generation of teenage killers. Here is the inside story.

Drug dealers beware. The Devil is coming to get you. Gangster Stephen French invented the perfect crime: robbing drug barons of their huge fortunes. In SAS-style swoops, French raided their fortified mansions and tortured them with horrifying violence until they paid up. Through 'taxing' the richest and most powerful crimelords in the UK, he netted over GBP20 million. French was no ordinary criminal. He was a world-champion fighter, he studied psychology at university to master mind-control techniques, and he used the teachings of Machiavelli and samurai warriors to outwit his enemies. The Devil also reveals French's complex relationship with Curtis Warren, the wealthiest criminal in British history. The two were childhood pals, then partners and finally bitter enemies. Now a legitimate businessman, French built up a multimillion-pound empire. Having eventually turned his back on his former life, he is now seeking to set the record straight.

Powder Wars is the true story of the supergrass who brought down Britain's biggest drug dealers. Gangster Paul Grimes was a one-man crimewave with a breathtaking capacity to steal. Any villains who got in his way were made to pay - often with their blood. But when his son died of a drugs overdose, the old-school mobster swore revenge on the new generation of Liverpool-based heroin and cocaine dealers. Against all odds, he turned undercover informant. The first gangster to fall foul of Grimes's change of heart was Curtis Warren, aka 'Cocky', the wealthiest and most successful criminal in British history. Grimes infiltrated his cocaine cartel and led Customs to the largest narcotics seizure on record, putting Warren in the dock in the drugs trial of the twentieth century. After turning his attention to heroin baron John Haase, Grimes rose to become the boss of the villain's notoriously bloodthirsty 'security firm' - a professional gang of rapid-fire, round-the-clock racketeers addicted to cocaine, explosive violence and non-stop criminality. drug dealers and broker the sale of swag - lorry loads of stolen whisky and designer sportswear worth hundreds of thousands of pounds. Finally, as his net began to tighten, Grimes was confronted with the ultimate dilemma. He discovered his second son was now a rising star in the drugs business. Should he shop him or not, was the life-or-death question. Powder Wars also reveals the secrets behind one of the most controversial episodes in British judicial history - how former Home Secretary Michael Howard was duped into granting John Haase a Royal Pardon, a decision that has come back to haunt the Tory leader. Today Paul Grimes has a GBP 100,000 contract on his head and is a real-life dead man walking. Powder Wars is a riveting account of modern gangsters told in brutal detail.

This book, the first of its kind to be published in English, introduces the reader to the rich heritage of Spanish song. Here in one volume are the texts of over 300 songs with parallel translations in accurate and readable English. The majority are love poems, which form a fascinating anthology of Spanish poetry from the thirteenth to the twentieth century. The introduction by Graham Johnson, who in recent years has done more than anyone to kindle interest in the international song repertoire, traces the history of Spanish song from its beginnings, via the period of the Catholic kings in the fifteenth century, the Golden Age of the sixteenth, through to the remarkable rebirth in the twentieth century. All the songs and cycles frequently heard in recital are gathered here: Albeniz, Falla, Granados, Rodrigo and Obradors are generously represented, as well as Catalan composers such as Montsalvatge and Mompou. The volume is arranged chronologically by composer, and includes notes on all the major poets and composers, a discography, and names and addresses of the music publishers. The Spanish Song Companion is a much-needed volume and will be welcomed by singers, students of Spanish literature, concert-goers and record-collectors throughout the English-speaking world.