0
Your cart

Your cart is empty

Browse All Departments
  • All Departments
Price
  • R1,000 - R2,500 (1)
  • -
Status
Brand

Showing 1 - 1 of 1 matches in All Departments

Systemic & Metabolic Changes Observed in Alcohol Dependent Male Patients After Alcohol Withdrawal (Paperback): Maria Klopocka,... Systemic & Metabolic Changes Observed in Alcohol Dependent Male Patients After Alcohol Withdrawal (Paperback)
Maria Klopocka, Jacek Budzynski, Maciej Swiatkowski, Grzegorz Pulkowski
R1,193 R1,118 Discovery Miles 11 180 Save R75 (6%) Ships in 12 - 19 working days

Alcohol abuse is associated with psycho-somatic health and social problems. It leads to multi-organ, especially cardiovascular system, alimentary tract, liver, pancreas and immunologic system dysfunction. Therefore withdrawal and anti-relapse therapy should be undoubtedly undertaken in every case. Nevertheless our knowledge about alcohol withdrawal consequences is insufficient. The main purpose of the authors' investigation was to determine the metabolic, endocrine, haemostatic and immunologic changes during six-month long abstinence period. They studied the abstinence effect on exercise capacity and autonomic nervous system activity estimated by heart rate variability analysis. Their research concerned also changes in upper digestive tract macroscopic and microscopic appearance and its motility, liver function, pro- anti- oxidative balance parameters level, cytokine TNF- alpha and nitric oxide (NO) metabolites plasma concentration. The authors estimated inter-relationships between studied parameters, what seems to be very important in complete analysis. Within six-months long abstinence period pro-atherogenic metabolic changes expressed by decreased HDL and increased LDL- cholesterol plasma concentration occurred. These unfavourable changes were less expressed in patients treated with naltrexone. In the early abstinence period indirect markers of platelets activation were determined. The highest level of fibrinogen, thrombomodulin, antithrombin, markers of trombinogenesis activation in vivo (thrombin- antithrombin, TAT complexes), tissue type plasminogen activator antigen (t-PA:Ag), antigen of plasminogen activator inhibitor type 1 (PAI-1:Ag), markers of fibrinolysis activation in vivo, such as D-dimers, plasmin- alpha2- antiplasmin (PAP) complexes was also observed. Mentioned changes were expressed in patients with determinable TNF-alpha plasma level. Abstinence improved effort capacity, positively changed autonomic nervous system activity via vagal nerve influence on heart rate variability. The last finding was also affected by TNF-alpha level. No significant changes appeared in alimentary tract function, estimated by esophageal and gastric pH-metry, esophageal manometry and abdominal ultrasonography, whereas some changes were observed in endoscopic examinations and influence of patients mental status on investigated parameters became noticeable. Favourable effect on liver function tests was affected by pituitary-thyroid and pituitary-gonadal axes hormones, cytokine TNF-alpha, nutrition status, Helicobacter pylori infection and gastric acidity. Some of studied parameters, such as mean platelets volume and nitric oxide metabolites plasma level may be used as new, valuable markers of alcohol abuse. Alcohol withdrawal and early abstinence is a dynamic period with potentially harmful health consequences, especially in cardiovascular system. This suggests the need of multicentre studies to estimate clinical importance of found changes and cost- benefits analysis of selected interventions.

Free Delivery
Pinterest Twitter Facebook Google+
You may like...
Legkaart van 'n Jong Lewe - Essays Oor…
Dolf van Niekerk Paperback R209 Discovery Miles 2 090
Social Life of the Chinese - With Some…
Justus Doolittle Paperback R676 Discovery Miles 6 760
The Life and Times of Chinua Achebe
Kalu Ogbaa Hardcover R3,270 Discovery Miles 32 700
All Things Matthew 19:26 Bible Verse…
Christian Art Gifts Paperback R249 R229 Discovery Miles 2 290
Moonology Diary 2025
Yasmin Boland Paperback R452 R405 Discovery Miles 4 050
Joy For The Journey - Coloring Book
Amylee Weeks Spiral bound R316 R297 Discovery Miles 2 970
Modern Etiquette Wedding Planner - The…
Elisabeth Kramer Paperback R540 R511 Discovery Miles 5 110
The Collected Regrets Of Clover
Mikki Brammer Paperback R370 R342 Discovery Miles 3 420
The Little Liar
Mitch Albom Hardcover R510 R461 Discovery Miles 4 610
The Science of Business: Being the…
Arthur Frederick Sheldon Paperback R451 Discovery Miles 4 510

 

Partners