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Divided into five expansive sections, this guide provides an
in-depth review of crystal-induced arthritis and related disorders.
Providing a historical perspective throughout, this work includes
detailed descriptions of the clinical features of these diseases,
as well as a current overview of their identification,
epidemiology, genetics, and underlying pathophysiology. This
authoritative guide also reviews case studies, current diagnostic
tools, and the prevalence of these conditions while introducing new
and emerging therapies for disease management.
While an emphasis on the new is vital to any science, the relevance
or importance of new discoveries cannot truly be appreciated
without a strong sense of the framework of a discipline, and of the
ideas that helped to shape it. With this in mind, the editors of
this book have attempted to create a canon of texts that formed the
basis of rheumatology. Experts on the diagnosis and management of
the various rheumatological conditions have chosen what they
consider to be the key papers in their respective domains. Every
paper is carefully described and evaluated by its strengths, its
weaknesses, and its contribution to the field. Papers have been
chosen that define new diseases or treatments, that have changed
our whole way of thinking, or that have simply stood the test of
time. The editors hope that the papers profiled in this volume will
stimulate debate, encourage readers to seek out the original texts,
and inspire the writers of the classics of the 21st century.
This volume reviews the state-of-the-art in osteoarthritis. The
pathogenetic roles of mechanical, systemic and inflammatory factors
and the importance of neurogenic factors in pain management and in
the causes of disease are considered. Of particular value is the
review of the implications of pathogenetic mechanisms in future
modes of management. The concept of "activated arthrosis" is given
special attention. Finally, controversial issues and new areas for
investigation are discussed. The book will help the clinician and
the investigator consider the importance of addressing different
phases and subtypes of osteoarthritis in planning treatment.
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