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Natural Products as Antiviral Agents (Hardcover, 1992 ed.): C.K. Chu, H.G. Cutler Natural Products as Antiviral Agents (Hardcover, 1992 ed.)
C.K. Chu, H.G. Cutler
R2,609 Discovery Miles 26 090 Ships in 12 - 19 working days

During the past fifty years, thousands of natural products have been isolated from plants, fungi, and bacteria. Apart from intense searches by pharmaceutical companies for medicinals and the concentrated effort mounted by the National Cancer Institute, many of these have not been tested in biological systems. The major reasons for this appear to be, at least, twofold. First, individual researchers looking for biologically active natural products will often isolate only small amounts of material sufficient to determine a structure and calculate the specific activity for their particular bioassay systems: insufficient funds preclude re-isolating the compound unless industrial potential is foreseen. Second, the difficulty with which original structures were proved prior to 1972. This required the isolation of relatively large quantities of a natural product and there followed extensive degradation, elemental analyses of the parent and its fragments, then synthesis, piece by piece, of the molecule. All this took time and energy. No wonder that when the structure was proved the chemist was enervated. And coupled to this was the fact that many chemists were not trained to test their materials in biological systems. In contrast, today a natural product can be isolated, its mass and molecular formula determined and, if there is some serendipity, crystals may be obtained for single crystal x-ray analysis. If conditions are near perfect, it is possible to isolate and identify a novel compound in a month.

Natural Products as Antiviral Agents (Paperback, Softcover reprint of the original 1st ed. 1992): C.K. Chu, H.G. Cutler Natural Products as Antiviral Agents (Paperback, Softcover reprint of the original 1st ed. 1992)
C.K. Chu, H.G. Cutler
R1,542 Discovery Miles 15 420 Ships in 10 - 15 working days

During the past fifty years, thousands of natural products have been isolated from plants, fungi, and bacteria. Apart from intense searches by pharmaceutical companies for medicinals and the concentrated effort mounted by the National Cancer Institute, many of these have not been tested in biological systems. The major reasons for this appear to be, at least, twofold. First, individual researchers looking for biologically active natural products will often isolate only small amounts of material sufficient to determine a structure and calculate the specific activity for their particular bioassay systems: insufficient funds preclude re-isolating the compound unless industrial potential is foreseen. Second, the difficulty with which original structures were proved prior to 1972. This required the isolation of relatively large quantities of a natural product and there followed extensive degradation, elemental analyses of the parent and its fragments, then synthesis, piece by piece, of the molecule. All this took time and energy. No wonder that when the structure was proved the chemist was enervated. And coupled to this was the fact that many chemists were not trained to test their materials in biological systems. In contrast, today a natural product can be isolated, its mass and molecular formula determined and, if there is some serendipity, crystals may be obtained for single crystal x-ray analysis. If conditions are near perfect, it is possible to isolate and identify a novel compound in a month.

Panorama of Nations - Or, Journeys Among the Families of Men (Paperback): H.G. Cutler, L.W. Yaggy Panorama of Nations - Or, Journeys Among the Families of Men (Paperback)
H.G. Cutler, L.W. Yaggy
R1,337 Discovery Miles 13 370 Ships in 10 - 15 working days
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