This book constitutes the proceedings of the 21th International Conference on Coordination Models and Languages, COORDINATION 2019, held in Kongens Lyngby, Denmark, in June 2019, as part of the 14th International Federated Conference on Distributed Computing Techniques, DisCoTec 2019. The 15 full papers included in this volume were carefully reviewed and selected from 25 submissions. The papers are organized in topical sections named: computational models; tools; exploring new frontiers; and coordination patterns.

This volume presents the refereed proceedings from the 14th International Symposium on Static Analysis. The papers address all aspects of static analysis, including abstract domains, abstract interpretation, abstract testing, compiler optimizations, control flow analysis, data flow analysis, model checking, program specialization, security analysis, theoretical analysis frameworks, type-based analysis, and verification systems.

Semantics will play an important role in the future development of software systems and domain-specific languages. This book provides a needed introductory presentation of the fundamental ideas behind these approaches, stresses their relationship by formulating and proving the relevant theorems, and illustrates the applications of semantics in computer science. Historically important application areas are presented together with some exciting potential applications. The text investigates the relationship between various methods and describes some of the main ideas used, illustrating these by means of interesting applications. The book provides a rigorous introduction to the main approaches to formal semantics of programming languages.

This volume, the 7th in the Transactions on Computational Systems Biology series, contains a fully refereed and carefully selected set of papers from two workshops: BioConcur 2004 held in London, UK in August 2004 and BioConcur 2005 held in San Francisco, CA, USA in August 2005.

The 8 papers chosen for this special issue are devoted to various aspects of computational methods, algorithms, and techniques in bioinformatics.

The authors describe here a framework in which the type notation of functional languages is extended to include a notation for binding times (that is run-time and compile-time) that distinguishes between them. Consequently the ability to specify code and verify program correctness can be improved. Two developments are needed, the first of which introduces the binding time distinction into the lambda calculus, in a manner analogous with the introduction of types into the untyped lambda calculus. Methods are also presented for introducing combinators for run-time. The second concerns the interpretation of the resulting language, which is known as the mixed lambda-calculus and combinatory logic. The notion of 'parametrized semantics' is used to describe code generation and abstract interpretation. The code generation is for a simple abstract machine designed for the purpose; it is close to the categorical abstract machine. The abstract interpretation focuses on a strictness analysis that generalises Wadler's analysis for lists.

The authors describe here a framework in which the type notation of functional languages is extended to include a notation for binding times (that is run-time and compile-time) that distinguishes between them. Consequently, the ability to specify code and verify program correctness can be improved. Two developments are needed, the first of which introduces the binding time distinction into the lambda calculus in a manner analogous with the introduction of types into the untyped lambda calculus. Methods are also presented for introducing combinators for run-time. The second concerns the interpretation of the resulting language, which is known as the mixed lambda-calculus and combinatory logic. The notion of "parametrized semantics" is used to describe code generation and abstract interpretation. The code generation is for a simple abstract machine designed for the purpose, it is close to the categorical abstract machine. The abstract interpretation focuses on a strictness analysis that generalizes Wadler's analysis for lists. It is also shown how the results of abstract interpretation may be used to improve the code generation.