An intimate relation between hormones and lipoprotein metabolism has been known for a long time especially from hormone-deficiency or -overproduction syndromes. The mechanisms through which hormones influence lipid metabolism have become a field of major interest in sci ence. The more we learn about cellular hormonal actions the better we understand regulatory processes and phenomena occuring in patients. The present book summarizes data discussed at an International Meet ing at Marburg, Germany, on "Hormones in Lipoprotein Metabolism." It was an attempt to pull together knowledge in basic science from the mode of action of hormones all the way to clinical appearance of hor monal disorders involving lipoprotein metabolism. Thus data on molec ular biology, on hormonal regulation of apolipoprotein synthesis, on lipoprotein receptors and enzyme induction are discussed together with the large field of oral contraceptive use, postmenopausal estrogen sub stitution, lipid disorders in diabetes mellitus, in thyroid dysfunction, in adrenal insufficiency and in glucocorticoid application. We are aware of the fact that such an overview cannot be complete but should serve as a collection of data and ideas for those interested in hormonal regulation of lipid metabolism. We thank all authors for taking an extra effort in writing up their presentations and thus making this edition possible. We also thank Bristol-Myers-Squibb for generous support of the meeting and of the final publication. Marburg, Germany ARMIN STEINMETZ JURGEN SCHNEIDER HANS KAFFARNIK Contents Molecular Biology Chairmen: D. J. Rader, A."

A number of clinical and epidemiological studies have shown that disorders of lipoprotein metabolism constitute one of the most important risk factors for the development of atherosclerosis and coronary heart disease. This volume examines the state of the art of lipoprotein subclass metabolism and its relation to these diseases. The authors also report on new developments concerning the role of lipoprotein recptors, macrophages and apolipoprotein E polymorphism in cholesterol homeostasis. The combination of general outline form and very specific aspects of cholesterol transport will interest those in other disciplines following developments in the field, as well as those directly involved in lipoprotein research.

Die Ressourcen im Gesundheitswesen stehen vor einschneidenden Einschr{nkungen. Das zwingt in der Praxis dazu, die M-glichkeiten der prim{ren und sekund{ren Pr{vention gezielt einzusetzen. Die hier vorgelegten Beitr{ge erm-glichen die Beurteilung, ob die Behandlung einer Fettstoffwechselst-rung sinnvoll, erforderlich und m-glich ist und mit welchen Ma nahmen bis zu welchen Zielwerten sie durchgef}hrt werden kann.

Fettstoffwechselstorungen gehoren mit zu den Hauptrisikofaktoren fur die Entstehung der koronaren Herzkrankheit. Das vorliegende Buch enthalt aktuelle Richtwerte zur Behandlung der Hyperlipoproteinamien und neuzeitliche diatetische und medikamentose Therapieprinzipien einschliesslich der extrakorporalen LDL-Elimination. Ausserdem werden die rheologischen Begleiteffekte einer lipidsenkenden Therapie sowie die Behandlungsmoglichkeiten im Kindesalter besprochen.