The study of antigen presenting cells being established within the human eye is universal knowledge, however, on going research has shown us that antigen-presenting cells play a key role in the protection against and the encouragement of disease within the human eye. It has also been shown that antigen presenting cells have a conclusive role in various ocular disorders, including but not limited to, glaucoma, infections, inflammation, and age related macular degeneration. With proof that interactions between T-cells and antigen-presenting cells can result in an immunological tolerance, future therapies are guaranteed to target antigen presenting cells to reduce the immune tolerance to the structure of the eye. Within this text, you will find description based chapters, with current up to date knowledge, explaining the role of antigen-presenting cells and each key ocular disorder relating to them.

This book is centered on a comprehensive list of MHC peptide motifs and ligands as known to date, together with selected T cell epitopes, arranged in an easy-to-read fashion. This information is put into context by chapters on MHC gene organization, MHC structure, T cell epitope prediction, antigen processing and T cell responses. In addition, the book provides a great deal of complementary information: amino acid sequences of MHC class I alpha1 and alpha2 domains and of class II alpha1 and beta1 domains, the established or predicted composition and specificity of MHC pockets, notes on MHC nomenclature including old assignments and reference to useful internet addresses. A handy reference manual that should be helpful for all those dealing with MHC-associated peptides.