Distinguished international experts offer critical reviews of the major categories of posttranslational protein modification in neurons, as well as a comprehensive collection of state-of-the-art techniques for their analysis. They provide detailed and specific methods for studying protein phosphorylation/dephospohorylation, methylation, long chain fatty acylation, ADP-ribosylation, glycosylation, and glycosylphosphatidylinositol anchors. Using both conventional analytical and novel molecular biological approaches, these experts present important techniques and reagents and cite numerous examples from the neuroscience literature in a way that allows investigators to determine the best experimental approaches for their own systems. The book offers the most complete review of protein kinase and phosphatase inhibitor applications available.

Distinguished international experts offer critical reviews of the major categories of posttranslational protein modification in neurons, as well as a comprehensive collection of state-of-the-art techniques for their analysis. They provide detailed and specific methods for studying protein phosphorylation/dephospohorylation, methylation, long chain fatty acylation, ADP-ribosylation, glycosylation, and glycosylphosphatidylinositol anchors. Using both conventional analytical and novel molecular biological approaches, these experts present important techniques and reagents and cite numerous examples from the neuroscience literature in a way that allows investigators to determine the best experimental approaches for their own systems. The book offers the most complete review of protein kinase and phosphatase inhibitor applications available.

Pharmacology and physiology are the foundation of every anesthesia provider's training and clinical competency. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application, 2nd Edition, delivers the information you need in pharmacology, physiology, and molecular-cellular biology, keeping you current with contemporary training and practice. This thoroughly updated edition is your one-stop, comprehensive overview of physiology, and rational anesthetic drug selection and administration, perfect for study, review, and successful practice. Contains new chapters on Special Populations (anesthetic pharmacology in obesity, geriatrics, and pediatrics), Oral and Non-IV Opioids, Thermoregulation, Physiology and Pharmacology of Obstetric Anesthesia, Chemotherapeutic and Immunosuppresive Drugs, and Surgical Infection and Antimicrobial Drugs. Incorporates entirely new sections on Physics, Anatomy, and Imaging. Includes new information on consciousness and cognition, pharmacodynamics, the immune system, and anti-inflammatory drugs. Features user-friendly tables, figures, and algorithms (including 100 new illustrations), all presented in full color and designed to help explain complex concepts. Helps you understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these areas. Expert ConsultT eBook version included with purchase, which allows you to search all of the text, figures, and references from the book on a variety of devices

Selected as a Doody's Core Title for 2022 and 2023! Case-based and easy to use, Yao & Artusio’s Anesthesiology: Problem-Oriented Patient Managementis the bestselling study and review reference preferred by both residents and practicing anesthesiologists. The revised Ninth Edition prepares you for the oral and written boards with more than 60 real-world cases accompanied by questions that conform to the four areas of questioning on the oral boards, reinforcing step-by-step critical thinking about today’s surgical anesthesia and patient management. Fully revised throughout, including new coverage of hypertension geriatric anesthesia, enhanced recovery after surgery (ERAS), postoperative cognitive dysfunction (POCD) and updated references for further study and clarification. A consistent chapter format includes: presentation of a case; questions on medical disease and differential diagnosis, preoperative planning and preparation, intraoperative management, and postoperative management; and complete answers and discussion of the case. Problem-based approach emphasizes critical thinking, collaborative decision making, and problem-solving skills. Ideal for oral board and continuing education preparation. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.