Psychiatric diagnosis is experiencing a crisis of confidence. Current approaches are outmoded, with reform desperately needed. Clinical staging is a solution to this crisis. Clinical staging addresses the limitations of current diagnostic systems by recognising the full continuum or trajectory of mental illness from asymptomatic to chronic illness. It acknowledges the overlap between mental health symptoms during early stages and directly links each stage to treatment and underlying cognitive, neurological and biological changes. This approach enhances chances of early identification, promotes the implementation of safer treatments, and increases opportunities to alter the negative trajectory of mental disorders. This book comprehensively describes the conceptual basis of clinical staging in psychiatry, details current progress in identifying biomarkers for each stage, and explores the implications of staging on treatment and health systems. This book provides a foundation for transformational reform in psychiatric diagnosis.

Experts discuss the potential of early intervention to transform outcomes for people with mental disorders. Mental illness represents one of the largest disease burdens worldwide, yet treatments have been largely ineffective in improving the quality of life for millions of affected individuals-in part because approaches taken have focused on late-stage disorders in adulthood. This volume shifts the focus by placing the developmental stage of "youth" at the center of mental health. The contributors challenge current nosology, explore mechanisms that underlie the emergence of mental disorders, and propose a framework to guide early intervention. Offering recommendations for the future, the book holds that early intervention in youth has the potential to transform outcomes for people with mental disorders and to reconfigure the landscape of mental health. The contributors discuss epidemiology, classification, and diagnostic issues, including the benefits of clinical staging; the context for emerging mental disorders, including both biological and sociocultural processes; biological mechanisms underlying risk for psychopathology, including aspects of neural circuitry; and developing and implementing prevention and early intervention, including assessment and intervention modalities and knowledge translation in early treatment of schizophrenia. Contributors Nicholas B. Allen, Mario Alvarez-Jimenez, G. Paul Amminger, Shelli Avenevoli, Hannah F. Behrendt, Tolulope Bella-Awusah, Maximus Berger, Byron K. Y. Bitanihirwe, Drew Blasco, John D. Cahill, Joanne S. Carpenter, Andrew M. Chanen, Eric Y. H. Chen, Shane D. Colombo, Christoph U. Correll, Christopher G. Davey, Kim Q. Do, Damien A. Fair, Helen L. Fisher, Sophia Frangou, John Gleeson, Robert K. Heinssen, Ian B. Hickie, Frank Iorfino,Matcheri S. Keshavan, Kerstin Konrad, Phuong Thao D. Le, Francis Lee, Leslie D. Leve, Sarah A. Lieff, Cindy H. Liu, Beatriz Luna, Patrick D. McGorry, Urvakhsh Meherwan Mehta, Andreas Meyer-Lindenberg, Shreya V. Nallur, Cristopher Niell, Merete Nordentoft, Dost OEngur, George C. Patton, Tomas Paus, Ulrich Reininghaus, Bernalyn Ruiz, Fred Sabb, Akira Sawa, Michael Schoenbaum, Gunter Schumann, Elizabeth M. Scott, Jai Shah, Vinod H. Srihari, Ezra Susser, John Torous, Peter J. Uhlhaas, Swapna K. Verma, T. Wilson Woo, Stephen J. Wood, Lawrence H. Yang, Alison R. Yung