calcium exchanger, which is the topic of the final chapter of the book by N. Gabellini, A. Zatti, and E. Carafoli. Padova Zurich, Ernesto Carafoli February 2000 Joachim Krebs "Yes, calcium, that is everything ..." Contents Calcium Homeostasis and Its Evolution Robert J. P. Williams ...Evolution of EF-Hand Proteins Susumu Nakayama, Hiroshi Kawasaki and Robert Kretsinger...29 . Calmodulin Target Recognition: Common Mechanism and Structural Diversity Tao Yuan, Kyoko L. Yap and Mitsuhiko Ikura ...59 ...Calcium-Binding EGF-like Domains A. K. Downing, P. A. Handford and J. D. Campbell...83 ...Calmodulin-Dependent Protein Kinases Joachim Krebs...101 ...Structure of Calcineurin and Its Complex with Immunophilins Claude B. Klee ...125 ...2 The Ca + Pump of Sarcoplasmic and Endoplasmic Reticulum Membranes Giuseppe Inesi and Chikashi Toyoshima...143 ...2 The Plasma Membrane Ca + ATPase Danilo Guerini ...155 ...2 The Na+/Ca+ Exchanger: Structural Aspects, Function and Regulation Nadia Gabellini, Alessandra Zatti and Ernesto Carafoli ...173 ...Calcium Homeostasis and Its Evolution Robert J. P. Williams Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OXl 3QR, UK E-mail: Susie. Compton@chem. ox. ac. uk The homeostasis of calcium is managed very differently in different organisms. A general outline of homeostasis, a dynamic balanced flow, is therefore described before a description of the systems in particular classes of organism. The organisms are treated in the sequence: prokaryotes, single-cell eukaryotes and, lastly, multicellular organisms reaching up to man.

This book is a psychoanalytic and philosophical exploration of how the digital is transforming our perception of the world and our understanding of ourselves. Drawing on examples from everyday life, myth, and popular culture, this book argues that virtual reality is only the latest instantiation of the phenomenon of the virtual, which is intrinsic to human being. It illuminates what is at stake in our understanding of the relationship between the virtual and the real, showing how our present technologies both enhance and diminish our psychological lives. The authors claim that technology is a pharmakon - at the same time both a remedy and a poison - and in their writing exemplify a method that overcomes the polarization that compels us to regard it either as a liberating force or a dangerous threat in human life. The digital revolution challenges us to reckon with the implications of what is being called our posthuman condition, leaving behind our modern conception of the world as constituted by atemporal essences and reconceiving it instead as one of processes and change. The book's postscript considers the sudden plunge into the virtual effected by the 2020 global pandemic. Accessible and wide-reaching, this book will appeal not only to psychotherapists, psychoanalysts, and philosophers, but anyone interested in the ways virtuality and the digital are transforming our contemporary lives.

This book is a psychoanalytic and philosophical exploration of how the digital is transforming our perception of the world and our understanding of ourselves. Drawing on examples from everyday life, myth, and popular culture, this book argues that virtual reality is only the latest instantiation of the phenomenon of the virtual, which is intrinsic to human being. It illuminates what is at stake in our understanding of the relationship between the virtual and the real, showing how our present technologies both enhance and diminish our psychological lives. The authors claim that technology is a pharmakon - at the same time both a remedy and a poison - and in their writing exemplify a method that overcomes the polarization that compels us to regard it either as a liberating force or a dangerous threat in human life. The digital revolution challenges us to reckon with the implications of what is being called our posthuman condition, leaving behind our modern conception of the world as constituted by atemporal essences and reconceiving it instead as one of processes and change. The book's postscript considers the sudden plunge into the virtual effected by the 2020 global pandemic. Accessible and wide-reaching, this book will appeal not only to psychotherapists, psychoanalysts, and philosophers, but anyone interested in the ways virtuality and the digital are transforming our contemporary lives.

Seeing Wittgenstein Anew is the first collection to examine Ludwig Wittgenstein's remarks on the concept of aspect-seeing. These essays show that aspect-seeing was not simply one more topic of investigation in Wittgenstein's later writings, but, rather, that it was a pervasive and guiding concept in his efforts to turn philosophy's attention to the actual conditions of our common life in language. Arranged in sections that highlight the pertinence of the aspect-seeing remarks to aesthetic and moral perception, self-knowledge, mind and consciousness, linguistic agreement, philosophical therapy, and "seeing connections," the sixteen essays, which were specially commissioned for this volume, demonstrate the unity of not only Philosophical Investigations but also Wittgenstein's later thought as a whole. They open up novel paths across familiar fields of thought: the objectivity of interpretation, the fixity of the past, the acquisition of language, and the nature of human consciousness. Significantly, they exemplify how continuing consideration of the interrelated phenomena and concepts surrounding aspect-seeing might produce a fruitful way of doing philosophy. The volume includes a concordance for the unnumbered remarks in the various editions of Philosophical Investigations, including the latest (4th) edition.

This book describes the Kluane Boreal Forest Ecosystem Project which operated from 1986 to 1996 in the southwestern Yukon. It begins by describing the area and its physical setting, and then the background of the project and the wisdom that had accumulated to 1986, on how this system might operate. The details of the experiments set up are presented, partly to help the reader appreciate the difficulty of working at -40 degrees and partly to aid the reader should they contemplate doing similar experiements in the future. Then they examine the three trophic levels of plants, the herbivores, and the predators in detail to provide some surprises about how the individual species operate within the overall system. Finally, they synthesize their findings in a model of the boreal forest vertebrate community, and provide an overview of what they have discovered and what remains to be done. Over the ten years of this project a large number of students and researchers have joined together to produce a picture which makes major advances in our understanding of the boreal forest ecosystem.

Global temperatures and seawater levels rise; the world's smallest porpoise species looms at the edge of extinction; and a tiny emerald beetle from Japan flourishes in North America-but why does it matter? Who cares? With this concise, accessible, and up-to-date book, Charles J. Krebs answers critics and enlightens students and environmental advocates alike, revealing not why phenomena like these deserve our attention, but why they demand it. Highlighting key principles in ecology-from species extinction to the sun's role in powering ecosystems-each chapter introduces a general question, illustrates that question with real-world examples, and links it to pressing ecological issues in which humans play a central role, such as the spread of invasive species, climate change, overfishing, and biodiversity conservation. While other introductions to ecology are rooted in complex theory, math, or practice and relegate discussions of human environmental impacts and their societal implications to sidebars and appendices, Why Ecology Matters interweaves these important discussions throughout. It is a book rooted in our contemporary world, delving into ecological issues that are perennial, timeless, but could not be more timely.

In this book, the authors present current research in the study of the food sources, biological roles and health implications of oligosaccharides. Topics discussed in this compilation include functional oligosacchardes and their positive health benefits on the digestive system; prebiotic oligosaccharides; the role of human milk oligosaccharides in preventing respiratory infections in infants; alterations in the glycosylation patterns of alpha-1 glycoprotein in the diagnostic detection of breast cancer; production of oligosaccharides with low molecular weights, secoiridoids and phenolic glycosides from thermally treated olive by-products; supramolecular analytical applications of cyclodextrins and their derivatives using fluorescence spectroscopy; utilisation of soy oligosaccharides during fermentation by lactobacilli; impact of low oligosaccharide soybean meal on nutrient digestibility, growth performance, and carcass characteristics of broiler chickens; lipo-oligosaccharides in Miller Fisher Syndrome; and oligosaccharides from ancient beverages fermented by symbiotic cultures.

calcium exchanger, which is the topic of the final chapter of the book by N. Gabellini, A. Zatti, and E. Carafoli. Padova Zurich, Ernesto Carafoli February 2000 Joachim Krebs "Yes, calcium, that is everything ..." Contents Calcium Homeostasis and Its Evolution Robert J. P. Williams ...Evolution of EF-Hand Proteins Susumu Nakayama, Hiroshi Kawasaki and Robert Kretsinger...29 . Calmodulin Target Recognition: Common Mechanism and Structural Diversity Tao Yuan, Kyoko L. Yap and Mitsuhiko Ikura ...59 ...Calcium-Binding EGF-like Domains A. K. Downing, P. A. Handford and J. D. Campbell...83 ...Calmodulin-Dependent Protein Kinases Joachim Krebs...101 ...Structure of Calcineurin and Its Complex with Immunophilins Claude B. Klee ...125 ...2 The Ca + Pump of Sarcoplasmic and Endoplasmic Reticulum Membranes Giuseppe Inesi and Chikashi Toyoshima...143 ...2 The Plasma Membrane Ca + ATPase Danilo Guerini ...155 ...2 The Na+/Ca+ Exchanger: Structural Aspects, Function and Regulation Nadia Gabellini, Alessandra Zatti and Ernesto Carafoli ...173 ...Calcium Homeostasis and Its Evolution Robert J. P. Williams Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OXl 3QR, UK E-mail: Susie. Compton@chem. ox. ac. uk The homeostasis of calcium is managed very differently in different organisms. A general outline of homeostasis, a dynamic balanced flow, is therefore described before a description of the systems in particular classes of organism. The organisms are treated in the sequence: prokaryotes, single-cell eukaryotes and, lastly, multicellular organisms reaching up to man.

Seeing Wittgenstein Anew is the first collection to examine Ludwig Wittgenstein's remarks on the concept of aspect-seeing. These essays show that aspect-seeing was not simply one more topic of investigation in Wittgenstein's later writings, but, rather, that it was a pervasive and guiding concept in his efforts to turn philosophy's attention to the actual conditions of our common life in language. Arranged in sections that highlight the pertinence of the aspect-seeing remarks to aesthetic and moral perception, self-knowledge, mind and consciousness, linguistic agreement, philosophical therapy, and "seeing connections," the sixteen essays, which were specially commissioned for this volume, demonstrate the unity of not only Philosophical Investigations but also Wittgenstein's later thought as a whole. They open up novel paths across familiar fields of thought: the objectivity of interpretation, the fixity of the past, the acquisition of language, and the nature of human consciousness. Significantly, they exemplify how continuing consideration of the interrelated phenomena and concepts surrounding aspect-seeing might produce a fruitful way of doing philosophy. The volume includes a concordance for the unnumbered remarks in the various editions of Philosophical Investigations, including the latest (4th) edition.