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A NATO Advanced Study Institute on "New Developments in
Lipid-Protein Interactions and Receptor Function" was held on the
Island of Spetsai, Greece, from August 16-27, 1992. This Institute
was organized to bring together researchers in the field of
membrane organization and dynamics with those actively involved in
studies on receptor function, signal transduction mechanisms and
gene regulation. 2 Presentations and discussions focussed on the
regulation of intracellular Ca +-levels, on the second messengers
derived from inositol lipids and on the specific phospholipase C
isozymes involved in these processes. A major focus was on
G-proteins and the effect of lipid anchors on their function. These
principles of regulation were further discussed in the context of
receptors for acetylcholine, lysophosphatidic acid and low-density
lipoproteins. In addition, various aspects of the genomic
regulation of cell growth and differentiation by transcription
factors were presented. These topics were put into perspective by
discussing the most recent developments in lipid-protein
interactions, protein insertion into membranes, membrane lipid
organization and lipid dynamics as mediated by phospholipid
transfer proteins. This book presents the content of the major
lectures and a selection of the most relevant of the most important
topics posters. These proceedings offer a comprehensive account
presented during the course of the Institute. The book is intended
to make these proceedings accessible to a large audience.
A NATO Advanced study Institute on "Receptors, Membrane Trans port
and Signal Transduction", was held on the Island of Spet sai,
Greece, from August 16-27, 1988, in order to consider re cent
developments in membrane receptor research, membrane trans port and
signal transduction mechanisms. These topics were put in the larger
context of current knowledge on the structure and function of
membranes; connections between different fields of research were
established by in-depth dis cussions of energy transduction and
transport mechanisms. The general principles of regulation by
signal transduction and protein phosphorylation/dephosphorylation
were presented in the context of specific cellular processes.
Discussions included al so the role of protein tyrosine kinases
which are structurally related to oncogene products and, therefore,
implicated in va rious aspects of cell development and
transformation. This book presents the content of the major
lectures and a se lection of the most relevant posters presented
during the course of the Institute. The book is intended to make
the proceedings of the Institute accessible to a larger audience
and to offer a comprehensive account of those topics on receptors,
membrane transport and signal transduction that were discussed
extensive ly during the course of the Institute. February 1989 The
Editors CONTENTS I. G-PROTEINS, ADENYLATE CYCLASE AND PROTEIN
PHOSPHORYLATION Selective regulation of G proteins by Cell surface
receptors ......... .
This book consists of a series of reviews on selected topics within
the rapidly and vastly expanding field of membrane biology. Its aim
is to highlight the most significant and important advances that
have been made in recent years in understanding the structure,
dynamics, and functions of cell membranes. The progress that is
being made in research in this field is due to the application of
integrated experimental ap- proaches, utilizing sophisticated and
novel techniques in molecular biology, cell biology, biophysics and
biochemistry. Due to the advances made, many problems have been or
are being solved at the molecular level. With the help of an
Editorial Advisory Board consisting of Jean-Pierre Changeux
(Paris), Paolo Comoglio (Torino), Rainer Jaenicke (Regens- burg),
Sten Orrenius (Stockholm), Lorenzo Pinna (Padova), Konrad Sandhoff
(Bonn), and Gottfried Schatz (Basel), we have selected a number of
topics in areas in which progress has been particularly rapid, and
have invited internationally acknowledged experts in the field to
review these topics. The areas covered in this monograph are: 1)
Signal transduction; 2) Membrane traffic: Proteins and lipids; 3)
Bioenergetics: Energy transfer and membrane transport; 4) Cellular
ion homeostasis; 5) Growth factors and adhesion molecules; 6)
Structural analysis of mem- brane proteins; and 7) Membranes and
disease.
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