The third edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers.
Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical ResearchAddresses the vast opportunities for translation of basic science observations to the bedside through clinical researchDelves into data management and addresses how to collect data and use it for discoveryContains valuable, up-to-date information on how to obtain funding from the federal government

Principles and Practice of Clinical Research, Fourth Edition has been thoroughly revised to provide a comprehensive look at both the fundamental principles and expanding practice of clinical research. New to this edition of this highly regarded reference, authors have focused on examples that broadly reflect clinical research on a global scale while including a discussion of international regulations, studies, and implications. In addition to key topics such as bioethics, clinical outcome data, cultural diversity, protocol guidelines, and "omic" platforms, this edition contains new chapters devoted to electronic health records and information resources for clinical researchers, as well as the many opportunities associated with big data. Covering a vast number of topics and practical advice for both novice and advanced clinical investigators, this book is a highly relevant and essential resource for all those involved in conducting research.

Emerging Infections is a reprint of the inaugural volume of the thematic serial, "Biomedical Research Reports Series" that provides annual updates on hot topics of interest to a broad spectrum of the biomedical research community. This volume provides state-of-the-art reviews of the most important "new" and reemerging bacterial, viral, and parasitic infections, their life cycles, host defense evasion strategies, and clinical features. Emerging Infections includes in-depth coverage of the history of infectious disease outbreaks, population and evolutionary biology of human pathogens, and current epidemiological models that describe how ecological and demographic changes produce new epidemics. The book covers the major established pathogens as well as the new and sensational--mad cow disease, hantavirus pulmonary syndrome, pathogenic "E-coli, " and flesh-eating bacteria.
Key Features
* Discusses persisting problems in tuberculosis
* Covers pathogenic escherichia colo 0157: H7
* Explains the revival of Group A Streptococcal diseases
* Provides information on antibiotic resistance in bacteria
* Includes coverage of Korean hemorrhagic fever and hantavirus pulmonary syndrome
* Questions where the Ebola virus comes from and where is it going