This first title in SIAM's Spotlights book series is about the interplay between modeling, analysis, discretization, matrix computation, and model reduction. The authors link PDE analysis, functional analysis, and calculus of variations with matrix iterative computation using Krylov subspace methods and address the challenges that arise during formulation of the mathematical model through to efficient numerical solution of the algebraic problem. The book's central concept, preconditioning of the conjugate gradient method, is traditionally developed algebraically using the preconditioned finite-dimensional algebraic system. In this text, however, preconditioning is connected to the PDE analysis, and the infinite-dimensional formulation of the conjugate gradient method and its discretization and preconditioning are linked together. This text challenges commonly held views, addresses widespread misunderstandings, and formulates thought-provoking open questions for further research.

The investigation of the role of mechanical and mechano-chemical interactions in cellular processes and tissue development is a rapidly growing research field in the life sciences and in biomedical engineering. Quantitative understanding of this important area in the study of biological systems requires the development of adequate mathematical models for the simulation of the evolution of these systems in space and time. Since expertise in various fields is necessary, this calls for a multidisciplinary approach. This edited volume connects basic physical, biological, and physiological concepts to methods for the mathematical modeling of various materials by pursuing a multiscale approach, from subcellular to organ and system level. Written by active researchers, each chapter provides a detailed introduction to a given field, illustrates various approaches to creating models, and explores recent advances and future research perspectives. Topics covered include molecular dynamics simulations of lipid membranes, phenomenological continuum mechanics of tissue growth, and translational cardiovascular modeling. Modeling Biomaterials will be a valuable resource for both non-specialists and experienced researchers from various domains of science, such as applied mathematics, biophysics, computational physiology, and medicine.

This book consists of six survey contributions that are focused on several open problems of theoretical fluid mechanics both for incompressible and compressible fluids. The first article "Viscous flows in Besov spaces" by M area Cannone ad dresses the problem of global existence of a uniquely defined solution to the three-dimensional Navier-Stokes equations for incompressible fluids. Among others the following topics are intensively treated in this contribution: (i) the systematic description of the spaces of initial conditions for which there exists a unique local (in time) solution or a unique global solution for small data, (ii) the existence of forward self-similar solutions, (iii) the relation of these results to Leray's weak solutions and backward self-similar solutions, (iv) the extension of the results to further nonlinear evolutionary problems. Particular attention is paid to the critical spaces that are invariant under the self-similar transform. For sufficiently small Reynolds numbers, the conditional stability in the sense of Lyapunov is also studied. The article is endowed by interesting personal and historical comments and an exhaustive bibliography that gives the reader a complete picture about available literature. The papers "The dynamical system approach to the Navier-Stokes equa tions for compressible fluids" by Eduard Feireisl, and "Asymptotic problems and compressible-incompressible limits" by Nader Masmoudi are devoted to the global (in time) properties of solutions to the Navier-Stokes equa and three tions for compressible fluids. The global (in time) analysis of two dimensional motions of compressible fluids were left open for many years."