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Techniques for microfabricating intricate microfluidic structures
that mimic the microenvironment of tissues and organs, combined
with the development of biomaterials with carefully engineered
surface properties, have enabled new paradigms in and cell
culture-based models for human diseases. The dimensions of surface
features and fluidic channels made accessible by these techniques
are well-suited to the size scale of biological cells. Microfluidic
Cell Culture Systems applies design and experimental techniques
used in in microfluidics, and cell culture technologies to
organ-on-chip systems. This book is intended to serve as a
professional reference, providing a practical guide to design and
fabrication of microfluidic systems and biomaterials for use in
cell culture systems and human organ models. The book covers topics
ranging from academic first principles of microfluidic design, to
clinical translation strategies for cell culture protocols. The
goal is to help professionals coming from an engineering background
to adapt their expertise for use in cell culture and organ models
applications, and likewise to help biologists to design and employ
microfluidic technologies in their cell culture systems. This 2nd
edition contains new material that strengthens the focus on in
vitro models useful for drug discovery and development. One new
chapter reviews liver organ models from an industry perspective,
while others cover new technologies for scaling these models and
for multi-organ systems. Other new chapters highlight the
development of organ models and systems for specific applications
in disease modeling and drug safety. Previous chapters have been
revised to reflect the latest advances.
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