An introduction to the Central Dogma of molecular biology and information flow in biological systems. A systematic overview of the methods for generating gene expression data. Background knowledge on statistical modeling and machine learning techniques. Detailed methodology of analyzing gene expression data with an example case study. Clustering methods for finding co-expression patterns from microarray, bulkRNA and scRNA data. A large number of practical tools, systems and repositories that are useful for computational biologists to create, analyze and validate biologically relevant gene expression patterns. Suitable for multi-disciplinary researchers and practitioners in computer science and biological sciences.

With the rapid rise in the ubiquity and sophistication of Internet technology and the accompanying growth in the number of network attacks, network intrusion detection has become increasingly important. Anomaly-based network intrusion detection refers to finding exceptional or nonconforming patterns in network traffic data compared to normal behavior. Finding these anomalies has extensive applications in areas such as cyber security, credit card and insurance fraud detection, and military surveillance for enemy activities. Network Anomaly Detection: A Machine Learning Perspective presents machine learning techniques in depth to help you more effectively detect and counter network intrusion. In this book, you'll learn about: Network anomalies and vulnerabilities at various layers The pros and cons of various machine learning techniques and algorithms A taxonomy of attacks based on their characteristics and behavior Feature selection algorithms How to assess the accuracy, performance, completeness, timeliness, stability, interoperability, reliability, and other dynamic aspects of a network anomaly detection system Practical tools for launching attacks, capturing packet or flow traffic, extracting features, detecting attacks, and evaluating detection performance Important unresolved issues and research challenges that need to be overcome to provide better protection for networks Examining numerous attacks in detail, the authors look at the tools that intruders use and show how to use this knowledge to protect networks. The book also provides material for hands-on development, so that you can code on a testbed to implement detection methods toward the development of your own intrusion detection system. It offers a thorough introduction to the state of the art in network anomaly detection using machine learning approaches and systems.